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Condition: Fatty Liver Disease (FLD)
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Total 312 results found since Jan 2013.
Screening for non-alcoholic fatty liver disease using liver stiffness measurement and its association with chronic kidney disease and cardiovascular complications in patients with type 2 diabetes.
CONCLUSION: - These results suggest that NAFLD and significant LF (as assessed by FibroScan) are very commonly seen in T2DM outpatients with no known liver disease attending a secondary-care diabetes service, and that increased LF is associated with a greater proportion of chronic vascular complications, especially CKD.
PMID: 31786361 [PubMed - as supplied by publisher]
Source: Diabetes and Metabolism - November 27, 2019 Category: Endocrinology Authors: Mantovani A, Turino T, Lando MG, Gjini K, Byrne CD, Zusi C, Ravaioli F, Colecchia A, Maffeis C, Salvagno G, Lippi G, Bonora E, Targher G Tags: Diabetes Metab Source Type: research
The influence of biological sex and sex hormones on bile acid synthesis and cholesterol homeostasis
AbstractObesity and elevated serum lipids are associated with a threefold increase in the risk of developing atherosclerosis, a condition that underlies stroke, myocardial infarction, and sudden cardiac death. Strategies that aim to reduce serum cholesterol through modulation of liver enzymes have been successful in decreasing the risk of developing atherosclerosis and reducing mortality. Statins, which inhibit cholesterol biosynthesis in the liver, are considered among the most successful compounds developed for the treatment of cardiovascular disease. However, recent debate surrounding their effectiveness and safety prom...
Source: Biology of Sex Differences - November 26, 2019 Category: Biology Source Type: research
Nonalcoholic fatty liver disease with advanced fibrosis, stroke and cardiovascular disease
Parikh et al. conducted a cross-sectional study on the relationship of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis) with stroke, heart disease, and major cardiovascular disease [1]. As indicators of NAFLD-fibrosis, the Fibrosis-4 Score (FIB-4) and NAFLD Fibrosis Score (NFS) were used for the analysis. Adjusted odds ratio (OR) (95% confidence interval [CI]) of the FIB-4 for stroke was 1.87 (1.00 –3.50). In addition, adjusted ORs of NAFLD-fibrosis for heart disease and major cardiovascular disease significantly increased.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: Tomoyuki Kawada Tags: Letter to the Editor Source Type: research
Response to letter to the editor by Kawada on “Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke”
We thank Dr. Kawada for their interest [1] in our recent publication [2], in which we reported on the association between nonalcoholic fatty liver disease (NAFLD) fibrosis indices and stroke. In a large, nationally representative sample of Americans, we demonstrated a cross-sectional relationship between NAFLD-advanced fibrosis and prevalent, self-reported stroke, with variability in our findings depending on the liver fibrosis score used.
Source: Journal of the Neurological Sciences - November 6, 2019 Category: Neurology Authors: NealS. Parikh, Jose Gutierrez Tags: Letter to the Editor Source Type: research
Association between iron metabolism and cognitive impairment in older non-alcoholic fatty liver disease individuals: A cross-sectional study in patients from a Chinese center
This study examined whether iron metabolism is associated with cognitive impairment in older individuals.
A cross-sectional study was held in patients from a Chinese center. Individuals with NAFLD aged over 60 years were included if they did not have excessive alcohol intake and were free of stroke or dementia. Their cognitive function was assessed by the same neurologist. 3.0T H proton magnetic resonance spectroscopy (1H-MRS) was performed to evaluate the hippocampus of the participants without contraindication. t test and Chi-square test were used to analyze the data. Binary logistic regression was used for correlation ...
Source: Medicine - November 1, 2019 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
NAFLD Not Associated With Risk of Cardiovascular Disease NAFLD Not Associated With Risk of Cardiovascular Disease
Non-alcoholic fatty liver disease (NAFLD) is not associated with an increased risk of acute myocardial infarction (AMI) or stroke, according to a new cohort study in nearly 18 million Europeans.Reuters Health Information
Source: Medscape Medical News Headlines - October 27, 2019 Category: Consumer Health News Tags: Gastroenterology News Source Type: news
Causal relationships between obesity and the leading causes of death in women and men
by Jenny C. Censin, Sanne A. E. Peters, Jonas Bovijn, Teresa Ferreira, Sara L. Pulit, Reedik M ägi, Anubha Mahajan, Michael V. Holmes, Cecilia M. Lindgren
Obesity traits are causally implicated with risk of cardiometabolic diseases. It remains unclear whether there are similar causal effects of obesity traits on other non-communicable diseases. Also, it is largely unexplored whether there are any sex-specific differences in the causal effects of obe sity traits on cardiometabolic diseases and other leading causes of death. We constructed sex-specific genetic risk scores (GRS) for three obesity traits; body mass index (BM...
Source: PLoS Genetics - October 23, 2019 Category: Genetics & Stem Cells Authors: Jenny C. Censin Source Type: research
Association between nonalcoholic fatty liver disease with advanced fibrosis and stroke
There is an increasing appreciation of the cardiovascular implications of nonalcoholic fatty liver disease with advanced fibrosis (NAFLD-fibrosis). However, data regarding stroke risk are limited. We sought to investigate whether NAFLD-fibrosis is associated with stroke in addition to heart disease.
Source: Journal of the Neurological Sciences - October 12, 2019 Category: Neurology Authors: Neal S. Parikh, Lisa B. VanWagner, Mitchell S.V. Elkind, Jose Gutierrez Source Type: research
Non-alcoholic fatty liver disease and risk of incident acute myocardial infarction and stroke: findings from matched cohort study of 18 million European adults
Source: BMJ - October 8, 2019 Category: General Medicine Source Type: research
Weight-Loss Surgery Dramatically Lowers the Risk of Early Death, a New Study Finds
For decades, doctors have known that losing weight can significantly lower risk of heart disease and by extension, reduce the risk of dying from heart-related events such as stroke and heart attack. Studies have shown that both lifestyle changes including diet and exercise as well as medications and weight-loss surgery can improve heart disease risk factors such as obesity and diabetes, for example, but data supporting the benefits of any of these approaches in actually lowering rates of heart events such as heart attack and atrial fibrillation, or in reducing early deaths from heart disease, have been less robust. The dat...
Source: TIME: Health - September 2, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized diabetes Heart Disease Source Type: news
Brain involvement in non-alcoholic fatty liver disease (NAFLD): A systematic review
Non-alcoholic fatty liver disease (NAFLD) is associated with high cardiovascular morbidity and mortality which usually is considered to be related to cardiac involvement, while scarce attention is addressed to brain damage. Viceversa NAFLD is associated with asymptomatic brain lesions, alterations in cerebral perfusion and activity, cognitive impairment and brain aging and with increased risk and severity of both ischemic and haemorrhagic stroke. Besides known metabolic risk factors, NAFLD is characterized by a pro inflammatory state, which contributes to atherosclerosis and microglia activation, endothelial dysfunction, p...
Source: Digestive and Liver Disease - June 5, 2019 Category: Gastroenterology Authors: Rosa Lombardi, Silvia Fargion, Anna Ludovica Fracanzani Tags: Liver, Pancreas and Biliary Tract Source Type: research
A Novel Deep Neural Network Model for Multi-Label Chronic Disease Prediction
Conclusions concludes this work along with future work.
Dataset and Data Preprocessing
In the work, we mainly focus on multiple chronic disease classification. It can be formulated into a multi-label classification problem. There are three common chronic diseases are selected from the physical examination records: hypertension (H), diabetes (D), and fatty liver (FL).
In the experiments, the physical examination datasets are collected from a local medical center, which contain 110,300 physical examination records from about 80,000 anonymous patients (Li et al., 2017a,b). Sixty-two feature items are selected from over 100...
Source: Frontiers in Genetics - April 23, 2019 Category: Genetics & Stem Cells Source Type: research
Study: Skipping Breakfast Tied To Higher Risk Of Heart-Related Death
(CNN) — Whether you eat breakfast might be linked with your risk of dying early from cardiovascular disease, according to a new study.
Skipping breakfast was significantly associated with an increased risk of cardiovascular-related death, especially stroke-related death, in the study published in the Journal of the American College of Cardiology on Monday.
After a person’s age, sex, race, socioeconomic status, diet, lifestyle, body mass index and disease status were taken into account, the study found that those who never had breakfast had a 87% higher risk of cardiovascular mortality compared with people who h...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - April 22, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Disease Source Type: news
Exercise as a Prescription for Patients with Various Diseases
Publication date: Available online 18 April 2019Source: Journal of Sport and Health ScienceAuthor(s): Xin Luan, Xiangyang Tian, Haixin Zhang, Rui Huang, Na Li, Peijie Chen, Ru WangAbstractA growing understanding of the benefits of exercise over the past few decades has prompted researchers to take an interest in the possibilities of exercise therapy. Because each sport has its own set of characteristics and physiological complications that tend to appear during exercise training, the effects and underlying mechanisms of exercise remain unclear. Thus, the first step in probing exercise effects on different diseases is the s...
Source: Journal of Sport and Health Science - April 20, 2019 Category: Sports Medicine Source Type: research
Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 17, 2019 Category: Physiology Source Type: research
