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Total 2156 results found since Jan 2013.

MiRNA-424 Protects Against Permanent Focal Cerebral Ischemia Injury in Mice Involving Suppressing Microglia Activation Basic Sciences
Conclusions— MiR-424 overexpression lessened the ischemic brain injury through suppressing microglia activation by translational depression of key activators of G1/S transition, suggesting a novel miR-based intervention strategy for stroke.
Source: Stroke - May 24, 2013 Category: Neurology Authors: Zhao, H., Wang, J., Gao, L., Wang, R., Liu, X., Gao, Z., Tao, Z., Xu, C., Song, J., Ji, X., Luo, Y. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research

Relationship between the induction of inflammatory processes and infectious diseases in patients with ischemic stroke.
Abstract Pro-inflammatory cytokines participate in the induction of ischemic stroke. So far, their participation in the cerebral ischemia was proven for the tumor necrosis factor TNF-α, interleukin-1 (IL-1), and interleukin-6 (IL-6). The release of the pro-inflammatory cytokines into the extracellular space causes the enlargement of the brain damage region, and consequently increases the neurological deficit and negatively affects the survival rate prognoses. That is confirmed by the increased concentration of pro-inflammatory cytokines in blood and the cerebrospinal fluid of patients with brain stroke, as well a...
Source: Acta Biochim Pol - September 18, 2013 Category: Biochemistry Authors: Cieślak M, Wojtczak A, Cieślak M Tags: Acta Biochim Pol Source Type: research

Postacute Stromal Cell-Derived Factor-1{alpha} Expression Promotes Neurovascular Recovery in Ischemic Mice Basic Sciences
Conclusions— SDF-1α promoted neurogenesis and angiogenesis during the postacute phase of ischemia without eliciting an inflammatory response. AAV-SDF-1α expression represents a promising avenue for ischemic stroke therapy with a wider treatment window.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Li, Y., Huang, J., He, X., Tang, G., Tang, Y.-H., Liu, Y., Lin, X., Lu, Y., Yang, G.-Y., Wang, Y. Tags: Angiogenesis, Animal models of human disease Basic Sciences Source Type: research

Attenuation of acute stroke injury in rat brain by minocycline promotes blood¿brain barrier remodeling and alternative microglia/macrophage activation during recovery
Conclusions: Early minocycline treatment against reperfusion injury significantly promotes neurovascular remodeling during stroke recovery by reducing brain tissue loss, enhancing TJP expression in ischemic brains and facilitating neuroprotective phenotype alternative activation of microglia/macrophages.
Source: Journal of Neuroinflammation - February 10, 2015 Category: Neurology Authors: Yirong YangVictor SalayandiaJeffrey ThompsonLisa YangEduardo EstradaYi Yang Source Type: research

Triptolide Protects Against Ischemic Stroke in Rats
In this study, we investigated the effects of triptolide on cultured neuronal cell line in vitro and experimental ischemic stroke in vivo. Oxygen–glucose deprivation (OGD) and tumor necrosis factor-α (TNF-α) stimulated SH-SY5Y cells were incubated with triptolide. In vivo, rats were subjected to middle cerebral artery occlusion (MCAO) for 1 h, followed by reperfusion for 23 h. Results of this study showed that triptolide treatment reduced the OGD-induced cytotoxicity and apoptosis and blocked TNF-α-induced activation of NF-κB and p38MAPK in SH-SY5Y cells. Intraperitoneal injection of triptolide showed significant n...
Source: Inflammation - February 17, 2015 Category: Allergy & Immunology Source Type: research

Diffusion Tensor Imaging in Hemorrhagic Stroke.
Abstract Diffusion Tensor Imaging (DTI) has evolved considerably over the last decade to now be knocking on the doors of wider clinical applications. There have been several efforts over the last decade to seek valuable and reliable application of DTI in different neurological disorders. The role of DTI in predicting outcomes in patients with brain tumors has been extensively studied and has become a fairly established clinical tool in this scenario. More recently DTI has been applied in mild traumatic brain injury to predict clinical outcomes based on DTI of the white matter tracts. The resolution of white matter...
Source: Experimental Neurology - May 23, 2015 Category: Neurology Authors: Chaudhary N, Pandey AS, Gemmete JJ, Hua Y, Huang Y, Gu Y, Xi G Tags: Exp Neurol Source Type: research

Clematichinenoside protects blood brain barrier against ischemic stroke superimposed on systemic inflammatory challenges through up-regulating A20
In conclusion, AR alleviated cerebral inflammatory injury through A20-NF-κB signal pathway, offering an alternative medication for stroke associated with systemic inflammatory diseases.
Source: Brain, Behavior, and Immunity - July 30, 2015 Category: Neurology Source Type: research

Risk factors for medical complications of acute hemorrhagic stroke
Conclusions Our study has assessed that hypertension followed by diabetes mellitus are the major risk factors for medical complications of hemorrhagic stroke. Female mortality rate was more when compared to males.\
Source: Journal of Acute Disease - August 4, 2015 Category: Emergency Medicine Source Type: research

Intraoperative Neurophysiological Evidence of Hydrogen Peroxide-Induced Stroke in Insular Tumor Surgery.
We present the case of a patient operated on for a right insular tumor with the assistance of intraoperative neurophysiological monitoring who developed a postoperative severe hemiparesis caused by a stroke in left middle cerebral artery territory due to the irrigation with H < sub > 2 < /sub > O < sub > 2 < /sub > . Based on this case, we recommend avoiding the H < sub > 2 < /sub > O < sub > 2 < /sub > irrigation for hemostasis in surgery for brain tumors when vascular structures are exposed. PMID: 26242351 [PubMed - in process]
Source: Turkish Neurosurgery - August 7, 2015 Category: Neurosurgery Authors: Jorba AL, Cuina ML, Principe A, Martinez GV Tags: Turk Neurosurg Source Type: research

Survivors of childhood cancer have high-risk of recurrent stroke
(University of California - San Francisco) A new study from the UCSF Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke, when compared with non-cancer stroke survivors.
Source: EurekAlert! - Cancer - August 26, 2015 Category: Cancer & Oncology Source Type: news

Midbrain and bilateral paramedian thalamic stroke due to artery of Percheron occlusion
Conclusion Bilateral thalamic stroke due to artery of Percheron occlusion is a rare presentation of stroke, which can be overlooked in routine CT scan. If diagnosed, it requires further evaluation for stroke risk factors, especially cardiovascular disorders associated with increased embolic risk.
Source: Polish Journal of Neurology and Neurosurgery - January 26, 2016 Category: Neurosurgery Source Type: research

Potential therapeutic and protective effect of curcumin against stroke in the male albino stroke-induced model rats
Publication date: Available online 27 June 2017 Source:Life Sciences Author(s): Yuanyuan Zhang, Yi Yan, Yi Cao, Yongtao Yang, Qing Zhao, Rui Jing, Jiayi Hu, Juan Bao Aims The present study was carried out to understand the therapeutic effect of curcumin (CUR) against stroke in the experimental animal model. The study investigates the healing effect of CUR on mitochondrial dysfunction and inflammation. Materials and methods Male albino, Wistar strain rats were used for the induction of middle cerebral artery occlusion (MCAO), and reperfusion. Enzyme-linked immunosorbent assay (ELISA) was used for the determination of inter...
Source: Life Sciences - June 27, 2017 Category: Biology Source Type: research

Protective Effects of Spatholobi Caulis Extract on Neuronal Damage and Focal Ischemic Stroke/Reperfusion Injury
AbstractNeuronal apoptotic cell death plays an important role in many neurological disorders, including Alzheimer ’s disease, Parkinson’s disease, and ischemic stroke. Spatholobi Caulis (SC) has been widely used in traditional herbal medicine for the treatment of cancer, inflammation, viral infection, and anemia. However, the protective effects of SC extract (SCE) against apoptotic cell death in the brain h ave not been reported. We investigated the protective effects of SCE against neuronal injury etoposide-induced neurotoxicity and in rats subjected to focal transient ischemic stroke middle cerebral artery occlusion ...
Source: Molecular Neurobiology - July 13, 2017 Category: Neurology Source Type: research

Application of Solution-Focused Brief Therapy (SFBT) in individuals after stroke.
CONCLUSIONS: The authors suggest SFBT as a simple, beneficial and inexpensive method to manage patients after stroke. PMID: 28696135 [PubMed - as supplied by publisher]
Source: Brain Injury - July 13, 2017 Category: Neurology Tags: Brain Inj Source Type: research

Therapeutic angiogenesis of exosomes for ischemic stroke.
Authors: Manuel GE, Johnson T, Liu D Abstract Angiogenesis is the process through which new blood vessels are formed, while therapeutic angiogenesis aims to promote and control the angiogenic response. Ischemia results from the lack of blood flow with oxygen and nutrients. Therapeutic angiogenesis is crucial in preserving brain tissue and bodily functions after ischemic stroke. Various approaches have been proposed to promote angiogenesis in ischemic diseases. Traditional protein/gene and subsequent stem/progenitor cell approaches have not shown consistent efficacy for ischemic diseases in clinical trials. Exosomes...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - January 21, 2018 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research