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Cancer: Brain Cancers
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Total 2156 results found since Jan 2013.
GAS6/Axl Signaling Modulates Blood-Brain Barrier Function Following Intravenous Thrombolysis in Acute Ischemic Stroke
ConclusionsLower serum Axl levels, which may result from sequence variations in GAS6-AS1, are correlated with an increased risk of HT after intravenous thrombolysis in stroke patients. Activation of the Axl signaling pathway by the GAS6 protein may serve as a therapeutic strategy to reduce HT in AIS patients.
Source: Frontiers in Immunology - October 18, 2021 Category: Allergy & Immunology Source Type: research
Post-ischemia common carotid artery occlusion worsens memory loss, but not sensorimotor deficits, in long-term survived stroke mice
Brain Res Bull. 2022 Mar 15:S0361-9230(22)00077-6. doi: 10.1016/j.brainresbull.2022.03.008. Online ahead of print.ABSTRACTIschemic stroke in rodents is usually induced by intraluminal occlusion of the middle cerebral artery (MCA) via the external carotid artery (ECA) or the common carotid artery (CCA). The latter route requires permanent CCA occlusion after ischemia, and here, we assess its effects on long-term outcomes. Transient occlusion of MCA and CCA was performed at normal body temperature. After 90minutes of ischemia, mice were randomized to permanent CCA occlusion or no occlusion (control group). Body weight, and m...
Source: Cancer Control - March 19, 2022 Category: Cancer & Oncology Authors: Zhong Yang Xuan Li Zhipeng Cao Peng Wang David S Warner Huaxin Sheng Source Type: research
Long non-coding RNA H19 promotes leukocyte inflammation in ischemic stroke by targeting the miR-29b/C1QTNF6 axis
CONCLUSIONS: Our findings confirm that H19 promotes leukocyte inflammation by targeting the miR-29b/C1QTNF6 axis in cerebral ischemic injury.PMID:35322553 | DOI:10.1111/cns.13829
Source: CNS Neuroscience and Therapeutics - March 24, 2022 Category: Neuroscience Authors: Guangwen Li Xiaoqing Ma Haiping Zhao Junfen Fan Tianwei Liu Yumin Luo Yunliang Guo Source Type: research
Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model
In this study, we used a mouse photothrombotic ischemic stroke model to examine the characteristics of astrocytes after the administration of minocycline during ischemic stroke. Minocycline increased astrocyte reactivity and affected the localization of astrocytes in the penumbra region. Molecular characterization revealed that the induced expression of mRNA encoding the fatty acid binding protein 7 (FABP7) by photothrombosis was enhanced by the minocycline administration. Meanwhile, minocycline did not significantly affect the phenotype or class of astrocytes. The expression of Fabp7 mRNA was well correlated with that of ...
Source: Neurochemical Research - July 30, 2022 Category: Neuroscience Authors: Mari Kondo Haruka Okazaki Kei Nakayama Hirofumi Hohjoh Kimie Nakagawa Eri Segi-Nishida Hiroshi Hasegawa Source Type: research
Can mental practice adjunct in the recovery of motor function in the upper limbs after stroke? A systematic review and meta-analysis
CONCLUSION: Current evidence does not support the use of the mental practice to increase the recovery of the upper limb after stroke, although the evidence is conflicting for some aspects of the technique.PMID:36267434 | PMC:PMC9578308 | DOI:10.4103/bc.bc_28_22
Source: Cancer Control - October 21, 2022 Category: Cancer & Oncology Authors: Danielle Aprigio Juliana Bittencourt Maria Ramim Victor Marinho Igor Brauns Isabelle Fernandes Pedro Ribeiro Bruna Velasques Ana Catarina Alves E Silva Source Type: research
Ischemic stroke in a patient with EGFR ‐mutated non–small‐cell lung cancer after treatment with ramucirumab
This article presents the case of a non–small-cell lun g cancer patient who experienced a new ischemic stroke after treatment with ramucirumab. The findings suggest that further studies may be necessary to investigate the relationship between ramucirumab and the risk of ischemic stroke.
Source: Thoracic Cancer - October 29, 2022 Category: Cancer & Oncology Authors: Guo ‐Yu Chen,
Wen‐Chien Cheng,
Chih‐Yen Tu Tags: CASE REPORT Source Type: research
Baicalin Reduces Immune Cell Infiltration by Inhibiting Inflammation and Protecting Tight Junctions in Ischemic Stroke Injury
In conclusion, baicalin could reduce BMECs apoptosis, protect tight junctions, and resist immune cell infiltration, thereby alleviating ischemic stroke. Our findings potentially provide a novel treatment strategy for ischemic stroke.PMID:36661075 | DOI:10.1142/S0192415X23500180
Source: The American Journal of Chinese Medicine - January 20, 2023 Category: Complementary Medicine Authors: Zhiyuan Hao Zheyu Zhang Yuhang Zhao Dongsheng Wang Source Type: research
Muscone promotes functional recovery by facilitating microglia polarization into M2 phenotype through PPAR- γ pathway after ischemic stroke
Cell Immunol. 2023 Mar 5;386:104704. doi: 10.1016/j.cellimm.2023.104704. Online ahead of print.ABSTRACTExploring regimens to facilitate microglia transformation from M1 to M2 phenotype is a feasible strategy to suppress neuroinflammation, therefore reinforcing functional recovery after ischemic stroke. Muscone easily crosses the blood brain barrier (BBB) and distributes throughout the brain. Here, the results illustrated the administration of 8 mg/kg muscone promoted functional recovery through reducing the infarct volume by 2,3,5-triphenyltetrazolium chloride (TTC) staining after ischemic stroke in mice. Then, the express...
Source: Cellular Immunology - March 15, 2023 Category: Allergy & Immunology Authors: Fei Liu Liwei Cao Shejing Hu Hongxiang Ye Qiang Wu Le Wu Source Type: research
