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A new era in stroke care gives larger treatment window and better outcomes
According to the American Heart/American Stroke Association, stroke affects nearly 800,000 people in the United States each year. It is the fifth leading cause of death, and the leading cause of long-term disability. It’s also the leading cause of preventable disability. In China it is the leading cause of death surpassing both cancer and heart disease.
Stroke occurs when a blood vessel carrying oxygen and nutrients to the brain is either blocked by a blood clot or plaque (ischemic stroke), or…
Source: bizjournals.com Health Care:Biotechnology headlines - August 15, 2018 Category: Biotechnology Authors: Alexandria Foley Source Type: news
Brain abscess complicating ischemic embolic stroke in a patient with cardiac papillary fibroelastoma – Case report and literature review
Publication date: Available online 13 May 2019Source: Journal of Clinical NeuroscienceAuthor(s): Monique Boukobza, Sarah Nahmani, Lydia Deschamps, Jean-Pierre LaissyAbstractA 72-year-old man without obvious risk factors initially presented with acute ischemic stroke and fever, without concomitant infection. Broad spectrum antibiotic therapy was initiated. Transthoracic and Transesophageal echocardiography, and cardiac MRI revealed a 20 mm round mass attached to the anterior mitral valve leaflet, suggesting the diagnosis of a benign cardiac tumor or a vegetation. At the site of infarction an abscess of 11 mm in diameter...
Source: Journal of Clinical Neuroscience - May 15, 2019 Category: Neuroscience Source Type: research
Wnt-3a alleviates neuroinflammation after ischemic stroke by modulating the responses of microglia/macrophages and astrocytes.
Abstract
Neuroinflammation crucially influences functional recovery after ischemic stroke. Wnt-3a, a novel Wnt protein that specifically promotes Wnt/β-catenin signaling pathway, has been shown to regulate apoptosis and cell proliferation, but how it affects ischemic stroke-induced toxic brain inflammation remains unknown. Using a transient middle cerebral artery occlusion (tMCAO) mouse model in this study, we found that intranasal Wnt-3a-treated tMCAO mice had apparently reduced infarct volume and decreased brain water content after being allowed to recover for 72 h, as well as better neurologic outcomes on da...
Source: International Immunopharmacology - July 15, 2019 Category: Allergy & Immunology Authors: Zhang D, Lu Z, Man J, Cui K, Fu X, Yu L, Gao Y, Liao L, Xiao Q, Guo R, Zhang Y, Zhang Z, Liu X, Lu H, Wang J Tags: Int Immunopharmacol Source Type: research
An Autopsy Case of Lambl's Excrescences with Trousseau Syndrome that Caused Cardioembolic Stroke.
Authors: Hirayama T, Morioka H, Fujiwara H, Iwamoto K, Kiyozuka T, Takeo H, Ikeda K, Kano O
Abstract
The frequency and risk of embolism by Lambl's excrescences (LEs) remain unclear. We herein report an autopsy case of LEs that caused cardioembolic stroke. A 74-year-old man with colon cancer was hospitalized for ischemic stroke. His D-dimer levels were elevated. Thus, a diagnosis of ischemic stroke with Trousseau syndrome was made. At the autopsy, we found LEs in the aortic valves and thromboembolism of the brain blood vessels. This finding demonstrated that fibrin clots had adhered to the LEs because of coagulation...
Source: Internal Medicine - August 14, 2020 Category: Internal Medicine Tags: Intern Med Source Type: research
Monoclonal antibody as an emerging therapy for acute ischemic stroke.
Authors: Woods D, Jiang Q, Chu XP
Abstract
Acute ischemic stroke (AIS) is the 5th leading cause of death and the leading cause of neurological disability in the United States. The oxygen and glucose deprivation associated with AIS not only leads to neuronal cell death, but also increases the inflammatory response, therefore decreasing the functional outcome of the brain. The only pharmacological intervention approved by the US Federal Food and Drug Administration for treatment of AIS is tissue plasminogen activator (t-PA), however, such treatment can only be given within 4.5 hours of the onset of stroke-like sympto...
Source: International Journal of Physiology, Pathophysiology and Pharmacology - September 18, 2020 Category: Physiology Tags: Int J Physiol Pathophysiol Pharmacol Source Type: research
SI – CROSSTALK: Mitochondrial‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 22, 2021 Category: Research Authors: Angeles Almeida,
Irene S ánchez‐Morán,
Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research
Mitochondrial ‐nuclear p53 trafficking controls neuronal susceptibility in stroke
SUMMARYStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and the impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and a poptosis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which controls protein localization, stability, and pro‐apoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis, through ...
Source: IUBMB Life - February 21, 2021 Category: Research Authors: Angeles Almeida,
Irene S ánchez‐Morán,
Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research
Mitochondrial –nuclear p53 trafficking controls neuronal susceptibility in stroke
AbstractStroke is a major cause of death and long ‐term disability in the adult. Neuronal apoptosis plays an essential role in the pathophysiology of ischemic brain damage and impaired functional recovery after stroke. The tumor suppressor protein p53 regulates key cellular processes, including cell cycle arrest, DNA repair, senescence, and apopt osis. Under cellular stress conditions, p53 undergoes post‐translational modifications, which control protein localization, stability, and proapoptotic activity. After stroke, p53 rapidly accumulates in the ischemic brain, where it activates neuronal apoptosis through both tra...
Source: IUBMB Life - March 2, 2021 Category: Research Authors: Angeles Almeida,
Irene S ánchez‐Morán,
Cristina Rodríguez Tags: CRITICAL REVIEW Source Type: research
Ferroptosis: an emerging therapeutic target in stroke
AbstractStroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed some molecular mechanism of brain injury after stroke, these studies cannot effectively translate into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically, and is characterized by iron‐dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently ...
Source: Journal of Neurochemistry - March 18, 2021 Category: Neuroscience Authors: Yibo Liu,
Yuanjian Fang,
Zeyu Zhang,
Yujie Luo,
Anke Zhang,
Cameron Lenahan,
Sheng Chen Tags: REVIEW ARTICLE Source Type: research
Development of Biomembrane-mimetic Nanoparticles for the Treatment of Ischemic Stroke
Yakugaku Zasshi. 2021;141(9):1071-1078. doi: 10.1248/yakushi.21-00114.ABSTRACTIncrease in vascular permeability of the blood-brain barrier (BBB) is a distinct pathology following ischemic stroke. In previous studies, we demonstrated that liposomal drug delivery system (DDS)-based delivery of neuroprotectants is useful for treating cerebral ischemia/reperfusion injury. Additionally, our previous studies reported that combination therapy with liposomal fasudil plus tissue plasminogen activator (t-PA), a thrombolytic agent, brings about decrease in the risk of t-PA-derived cerebral hemorrhage and prolong the therapeutic time ...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - September 2, 2021 Category: Drugs & Pharmacology Authors: Tatsuya Fukuta Source Type: research
