Ferroptosis: an emerging therapeutic target in stroke

AbstractStroke is a disastrous neurological disease with high morbidity and mortality. The mechanism of the pathological process is extremely complicated and unclear. Although many basic studies have confirmed some molecular mechanism of brain injury after stroke, these studies cannot effectively translate into treatment and clinical application. Ferroptosis is a form of cell death that is distinct from necrosis, apoptosis, and autophagy morphologically and biochemically, and is characterized by iron‐dependent accumulation of lipid peroxides. Despite ferroptosis being first identified in cancer cells, it was recently revealed to also be a significant factor in the pathological pr ocess of stroke. A better understanding of ferroptosis in stroke may provide us with better therapeutic targets to treat this devastating disease. Here, we systematically summarized the current mechanism of ferroptosis and reviewed the current studies regarding the relationship between ferroptosis a nd stroke.
Source: Journal of Neurochemistry - Category: Neuroscience Authors: Tags: REVIEW ARTICLE Source Type: research