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Total 508 results found since Jan 2013.

Long-Term Exposure to Ambient Fine Particulate Matter and Renal Function in Older Men: The Veterans Administration Normative Aging Study
Conclusions: In this longitudinal sample of older men, the findings supported the hypothesis that long-term PM2.5 exposure negatively affects renal function and increases renal function decline. Citation: Mehta AJ, Zanobetti A, Bind MC, Kloog I, Koutrakis P, Sparrow D, Vokonas PS, Schwartz JD. 2016. Long-term exposure to ambient fine particulate matter and renal function in older men: the VA Normative Aging Study. Environ Health Perspect 124:1353–1360; http://dx.doi.org/10.1289/ehp.1510269 Address correspondence to A.J. Mehta, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Landmark Ce...
Source: EHP Research - September 1, 2016 Category: Environmental Health Authors: Web Admin Tags: Research Article September 2016 Source Type: research

Mortality Analysis of the Life Span Study (LSS) Cohort Taking into Account Multiple Causes of Death Indicated in Death Certificates.
Abstract Mortality analyses have been performed using underlying causes of death as reported on death certificates; these are uniquely determined for a deceased person according to the World Health Organization coding system. Comorbidities, the disease conditions other than the underlying cause of death from death certificates recording multiple causes of death, have rarely been explored in Life Span Study subjects. The purpose of this study was to clarify associations between atomic bomb radiation exposure and mortality from combinations of the underlying cause of death and comorbidities. The focused follow-up pe...
Source: Radiation Research - December 18, 2016 Category: Physics Authors: Takamori A, Takahashi I, Kasagi F, Suyama A, Ozasa K, Yanagawa T Tags: Radiat Res Source Type: research

Longitudinal transition trajectory of gouty arthritis and its comorbidities: a population-based study
AbstractThe aim of the study was to investigate the longitudinal transition trajectory of gout and its comorbidities in male patients with gout in different age groups. A total of 3973 male patients who received a new diagnosis of gouty arthritis were identified from the Taiwan Longitudinal Health Insurance Database and divided into two age cohorts (<50 and ≥50 years). Each patient was individually followed from 2000 to 2009 to identify associated comorbidities, namely hypertension, hypercholesterolemia, diabetes mellitus, cardiovascular diseases, and chronic kidney disease. Two outcome measurements of stroke and all...
Source: Rheumatology International - December 20, 2016 Category: Rheumatology Source Type: research

Telomere Length, Long-Term Black Carbon Exposure, and Cognitive Function in a Cohort of Older Men: The VA Normative Aging Study
Conclusions: TL and CRP levels may help predict the impact of BC exposure on cognitive function in older men. Citation: Colicino E, Wilson A, Frisardi MC, Prada D, Power MC, Hoxha M, Dioni L, Spiro A III, Vokonas PS, Weisskopf MG, Schwartz JD, Baccarelli AA. 2017. Telomere length, long-term black carbon exposure, and cognitive function in a cohort of older men: the VA Normative Aging Study. Environ Health Perspect 125:76–81; http://dx.doi.org/10.1289/EHP241 Address correspondence to E. Colicino, Department of Environmental Health, Harvard T.H. Chan School of Public Health, 665 Huntington Ave., Building 1, Room G03, Bos...
Source: EHP Research - January 2, 2017 Category: Environmental Health Authors: Web Admin Tags: Research Articles January 2017 Source Type: research

Morbidity and Causes of Death in Patients with Cutaneous T-cell Lymphoma in Finland.
Abstract Cutaneous T-cell lymphomas (CTCL), especially mycosis fungoides, can be considered as a state of longstanding low-grade systemic inflammation. Many studies have focused on secondary cancers with CTCL, but information about comorbidities is limited. A total of 144 patients with CTCL at Helsinki University Central Hospital during 2005 to 2015 were studied to determine associated comorbidities and causes of death in this cohort. Compared with an age-standardized control population, the prevalence of type 2 diabetes mellitus was increased among patients with CTCL with no link to obesity. Patients with CTCL ha...
Source: Acta Dermato-Venereologica - February 7, 2017 Category: Dermatology Authors: Väkevä L, Lipsanen T, Sintonen H, Ranki A Tags: Acta Derm Venereol Source Type: research

Heart Transplant Outcomes in Patients With Pretransplant Diabetes Mellitus.
CONCLUSIONS: Heart transplant recipients with pretransplant diabetes fared just as well as patients without pretransplant diabetes in 7 of the 8 outcomes examined, except for the number of days hospitalized during the first 3 years after heart transplant. This study provides clinically important new information on the greater hospitalization time and the reasons for hospitalization during the first 3 years after heart transplant in patients with pretransplant diabetes. PMID: 29092871 [PubMed - in process]
Source: American Journal of Critical Care - November 1, 2017 Category: Nursing Authors: Jalowiec A, Grady KL, White-Williams C Tags: Am J Crit Care Source Type: research

Serum Beta Carotene and Overall and Cause-Specific Mortality.
CONCLUSIONS: This study provides evidence that higher beta carotene biochemical status is associated with lower overall, cardiovascular disease, heart disease, stroke, cancer, and other causes of mortality. The dose-response associations over a 30-year period were not attenuated by adjustment for other important risk factors and support greater fruit and vegetable consumption as a means to increase beta carotene status and promote longevity. PMID: 30566060 [PubMed - in process]
Source: Circulation Research - December 7, 2018 Category: Cardiology Authors: Huang J, Weinstein SJ, Yu K, Männistö S, Albanes D Tags: Circ Res Source Type: research

The Emergence of Non-communicable Disease in Indonesia.
Authors: Purnamasari D Abstract Based on data from the Indonesian Ministry of Health Information Center, the estimated population of Indonesia in 2016 was approximately 258,704,986 people, consisted of 129,988,690 men and 128,716,296 women. This number of Indonesian population represents young population since the proportion of population aged 0-14 years is more than that aged >14 years. Meanwhile, the proportion of population aged 50 years and above is significantly reduced, which is thought to be due to high mortality rate in the middle-aged population. The mortality rate in  Indonesia is dominated by non-com...
Source: Acta medica Indonesiana - January 13, 2019 Category: Internal Medicine Tags: Acta Med Indones Source Type: research

Years of Life Lost due to Premature Death in People with Disabilities in Korea: the Korean National Burden of Disease Study Framework.
Conclusion: The burden of disease was higher in the population with disabilities than that in the general population. Cardiovascular diseases and cancer had a higher burden of disease than did other diseases in the population with disabilities; thus, overall, non-communicable diseases have a higher burden of disease than communicable diseases or injuries in the population with disabilities than in the general population. PMID: 30636948 [PubMed - in process]
Source: Journal of Korean Medical Science - January 15, 2019 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Breast Cancer Screening Participation of Women with Chronic Diseases in Korea: Analysis of the 2012 Korean National Health and Nutrition Examination Survey
In conclusion, low participation rate in breast cancer screening in women with some chronic diseases was identified. The results from this study may provide an important contribution for helping to maintain and increase participation in cancer screening of patients with chronic diseases. PMID: 30678433 [PubMed - in process]
Source: Asian Pacific Journal of Cancer Prevention - January 28, 2019 Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research

Nut Consumption in Relation to Cardiovascular Disease Incidence and Mortality among Patients with Diabetes Mellitus.
CONCLUSIONS: Higher consumption of nuts, especially tree nuts, is associated with lower CVD incidence and mortality among participants with diabetes. These data provide novel evidence that supports the recommendation of incorporating nuts into healthy dietary patterns for the prevention of CVD complications and premature deaths among individuals with diabetes. PMID: 30776978 [PubMed - as supplied by publisher]
Source: Circulation Research - February 19, 2019 Category: Cardiology Authors: Liu G, Guasch-Ferre M, Hu Y, Li Y, Hu FB, Rimm EB, Manson JE, Rexrode K, Sun Q Tags: Circ Res Source Type: research

The lncRNA MALAT1 rs619586 G Variant Confers Decreased Susceptibility to Recurrent Miscarriage
In conclusion, our study suggests that the rs619586 G variant may have potential protective effects conferring a decreased risk of recurrent miscarriage in the southern Chinese population. Introduction Recurrent miscarriage is defined as the loss of two or more consecutive pregnancies before 20 weeks of gestation (Jaslow et al., 2010; Diejomaoh, 2015). The occurrence of recurrent miscarriage is associated with many factors, including genetic factors, immunological dysfunction, endocrine disorders, unhealthy lifestyles and defects of the reproductive organs (Saravelos and Regan, 2014; Sen et al., 2014; Garrido-Gimen...
Source: Frontiers in Physiology - April 8, 2019 Category: Physiology Source Type: research

Cardiovascular Programming During and After Diabetic Pregnancy: Role of Placental Dysfunction and IUGR
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - April 8, 2019 Category: Endocrinology Source Type: research

Canagliflozin Inhibits Human Endothelial Cell Proliferation and Tube Formation
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach
AbstractChronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. The algorithm included nine physiological parameters (c-reactive protein, creatinine, albumin, total cholesterol, cytomegalovirus optical dens...
Source: European Journal of Epidemiology - April 12, 2019 Category: Epidemiology Source Type: research