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Total 508 results found since Jan 2013.
Free Tissue Transfers for Head and Neck Reconstruction in Patients with End-Stage Renal Disease on Dialysis: Analysis of Outcomes Using the Taiwan National Health Insurance Research Database
Conclusion Despite greater preoperative risk factors, patients with renal failure on hemodialysis do not appear to have a higher rate of free flap failure following head and neck reconstruction. However, other complications can be minimized by optimizing patient's medical condition to succeed with this reconstructive effort. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text
Source: Journal of Reconstructive Microsurgery - June 16, 2017 Category: Surgery Authors: Manrique, Oscar J. Ciudad, Pedro Sharaf, Basel Martinez-Jorge, Jorys Moran, Steven Mardini, Samir Chen, Hung-Chi Bite, Uldis Cheng, Hsu-Tang Tags: Original Article Source Type: research
MicroRNAs Mediated MMP Regulation: Current Diagnostic and Therapeutic Strategies for Metabolic Syndrome.
Abstract
Metabolic syndrome (MS) is a global socioeconomic problem rapidly progressing in accordance with increasing body mass index (BMI) and age. It is a consortium of risk factors, such as dyslipidaemia, insulin resistance, leptin resistance, reduced adiponectin, glucose intolerance, hyperglycemia, and hypertension. Collectively, these factors accelerate the onset of type 2 diabetes mellitus, cardiovascular disease, stroke, and certain cancers such as breast, liver pancreatic, and colon cancer. Extracellular matrix (ECM) and basement membrane remodeling play a central role during pathogenesis of MS as they regu...
Source: Current Gene Therapy - July 7, 2017 Category: Genetics & Stem Cells Authors: Saxena S, Jain A, Rani V Tags: Curr Gene Ther Source Type: research
Obesity and inflammation: the linking mechanism and the complications.
Authors: Ellulu MS, Patimah I, Khaza'ai H, Rahmat A, Abed Y
Abstract
Obesity is the accumulation of abnormal or excessive fat that may interfere with the maintenance of an optimal state of health. The excess of macronutrients in the adipose tissues stimulates them to release inflammatory mediators such as tumor necrosis factor α and interleukin 6, and reduces production of adiponectin, predisposing to a pro-inflammatory state and oxidative stress. The increased level of interleukin 6 stimulates the liver to synthesize and secrete C-reactive protein. As a risk factor, inflammation is an imbedded mechanism of develo...
Source: Archives of Medical Science - July 20, 2017 Category: General Medicine Tags: Arch Med Sci Source Type: research
Acromegaly at diagnosis in 3173 patients from the Liege Acromegaly Survey (LAS) Database
In conclusion, this study of >3100 patients is the largest international acromegaly database and shows clinically relevant trends in the characteristics of acromegaly at diagnosis.
Source: Endocrine-Related Cancer - August 22, 2017 Category: Endocrinology Authors: Petrossians, P., Daly, A. F., Natchev, E., Maione, L., Blijdorp, K., Sahnoun-Fathallah, M., Auriemma, R., Diallo, A. M., Hulting, A.-L., Ferone, D., Hana, V., Filipponi, S., Sievers, C., Nogueira, C., Fajardo-Montanana, C., Carvalho, D., Hana, V., Stalla, Tags: Research Source Type: research
Analysis of p53 gene polymorphism (codon 72) in symptomatic patients with atherosclerosis.
Abstract
Atherosclerosis is a multifactorial pathological disease that alters the morphology and function of arterial walls. The atheroma growth leads to vessel hardening and lumen narrowing, limiting the blood flow. The atheroma plaque can eventually break, expose highly thrombogenic material and lead to platelet activation and subsequent formation of a thrombus that may block blood flow in loco, or even leading to obstruction of other vessels with a smaller diameter. This process is one of the main determinants of the clinical manifestations of atherosclerosis, such as coronary artery disease, ischemic stroke, a...
Source: Genetics and Molecular Research - August 17, 2017 Category: Genetics & Stem Cells Authors: Lagares MH, Silva KSF, Barbosa AM, Rodrigues DA, Costa IR, Martins JVM, Morais MP, Campedelli FL, Moura KKVO Tags: Genet Mol Res Source Type: research
MicroRNA profiling in MDA-MB-231 human breast cancer cell exposed to the Phaleria macrocarpa (Boerl.) fruit ethyl acetate fraction (PMEAF) through IIlumina Hi-Seq technologies and various in silico bioinformatics tools
Conclusion In conclusion, the results of this study proved that PMEAF is a promising anticancer agent with high cytotoxicity against MDA-MB-231 breast cancer cells and it induced apoptotic cell death mechanism through the regulation of miRNAs. PMEAF might be the best candidate for developing more potent anticancer drugs or chemo preventive supplements. Graphical abstract
Source: Journal of Ethnopharmacology - December 5, 2017 Category: Drugs & Pharmacology Source Type: research
The prevalence of Chronic Obstructive Pulmonary Disease (COPD) in Sri Lanka:outcome of the BOLD study
Conclusion: The prevalence of COPD in Sri Lankan adults is similar to global and regional prevalences.
Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Amarasiri, L., Gunasinghe, W., Sadikeen, A., Fernando, A., Madegedara, D., Wickramasinghe, R., Gunasekera, K. Tags: Epidemiology Source Type: research
Excess Clinical Comorbidity Among HIV-Infected Patients Accessing Primary Care in US Community Health Centers.
CONCLUSIONS: As HIV-infected patients live longer, the increasing burden of noncommunicable diseases may complicate their clinical management, requiring primary care providers to be trained in chronic disease management for this population.
PMID: 29262289 [PubMed - as supplied by publisher]
Source: Public Health Reports - December 22, 2017 Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
IJERPH, Vol. 15, Pages 25: Endocrine Disrupting Chemicals Mediated through Binding Androgen Receptor Are Associated with Diabetes Mellitus
Huixiao Hong
Endocrine disrupting chemicals (EDCs) can mimic natural hormone to interact with receptors in the endocrine system and thus disrupt the functions of the endocrine system, raising concerns on the public health. In addition to disruption of the endocrine system, some EDCs have been found associated with many diseases such as breast cancer, prostate cancer, infertility, asthma, stroke, Alzheimer’s disease, obesity, and diabetes mellitus. EDCs that binding androgen receptor have been reported associated with diabetes mellitus in in vitro, animal, and clinical studies. In this review, we summarize the struct...
Source: International Journal of Environmental Research and Public Health - December 23, 2017 Category: Environmental Health Authors: Sugunadevi Sakkiah Tony Wang Wen Zou Yuping Wang Bohu Pan Weida Tong Huixiao Hong Tags: Review Source Type: research
Are people at high risk for diabetes visiting health facility for confirmation of diagnosis? A population-based study from rural India.
CONCLUSION: Confirmation of diabetes was abysmally low in the study population. Low uptake of the confirmatory test might be due to low 'risk perception'. The uptake can be increased by improving the population risk perception through individual and/or community-focused risk communication interventions.
PMID: 29334333 [PubMed - in process]
Source: Global Health Action - January 16, 2018 Category: International Medicine & Public Health Tags: Glob Health Action Source Type: research
Opposite impact of Methylene tetrahydrofolate reductase C677T and Methylene tetrahydrofolate reductase A1298C gene polymorphisms on systemic inflammation
ConclusionsThis study indicates that MTHFR C677T and MTHFR A1298C gene polymorphisms have opposite effect on systemic inflammation, and systemic inflammation may contribute to the pathogenesis for diseases associated with MTHFR C667T gene polymorphism.
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Koroush Khalighi, Gang Cheng, Seyedabbas Mirabbasi, Bahar Khalighi, Yin Wu, Wuqiang Fan Tags: RESEARCH ARTICLE Source Type: research
What Is the Impact of Targeted Health Education for Mental Health Nurses in the Provision of Physical Health Care? An Integrated Literature Review.
Authors: Hennessy S, Cocoman AM
Abstract
Individuals with a severe mental illness have a gap in life expectancy of up to twenty years in comparison to the general population. Nurses who work in mental health services have been identified as best placed to improve the physical health outcomes of individuals with mental illness. The literature identifies a lack of nursing knowledge related to physical health care and the presence of metabolic syndrome which is impeding nurses in providing essential physical health care to patients. An integrated literature review was carried out due to the dearth of research evidence...
Source: Issues in Mental Health Nursing - February 22, 2018 Category: Nursing Tags: Issues Ment Health Nurs Source Type: research
The impact of the molecular diagnosis in the surveillance of the Clostridium difficile infection.
Authors: Bãicuş A, Cîrstoiu M, Lambru K, Plata F, Cîrstoiu CF
Abstract
Clostridium difficile is the agent of many cases of
antibiotic associated diarrhea. The prevalence of the
toxigenic Clostridium difficile strains was assessed by
real-time PCR between May 2014- January 2015, at the
Emergency University Hospital, Bucharest, Romania. The
incidence of the Clostridium difficile infection was 0.47%.
Among the 1119 stool specimens tested, 165 (13.8%)
were positive for C. difficile toxins A and B by
immunochromatography test. All 165 positive samples
were investigated by real time PCR and 134 (81%)
samples were pos...
Source: Roumanian Archives of Microbiology and Immunology - April 7, 2018 Category: Microbiology Tags: Roum Arch Microbiol Immunol Source Type: research
An update on physical health and economic consequences of overweight and obesity
Publication date: Available online 5 May 2018 Source:Diabetes & Metabolic Syndrome: Clinical Research & Reviews Author(s): Dinh-Toi Chu, Nguyen Thi Minh Nguyet, Thien Chu Dinh, Nguyen Vu Thai Lien, Khanh-Hoang Nguyen, Vo Truong Nhu Ngoc, Yang Tao, Le Hoang Son, Duc-Hau Le, Vu Bich Nga, Adam Jurgoński, Quoc-Hung Tran, Pham Van Tu, Van-Huy Pham Overweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world’s population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of com...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - May 5, 2018 Category: Endocrinology Source Type: research
Sporadic Burkitt Lymphoma Mimicking an Adnexal Tumor
A 77-year-old woman, gravida 4, para 4, visited our department because of sudden onset left abdominal dull pain without any aggravating or relieving factor as well as left lower limb numbness, which had occurred for 2 weeks. No changing bowel habit and diarrhea were mentioned. She had diabetes mellitus and hypertension, and had a prior history of two episodes of stroke. She had not undergone prior pelvic surgery or Papanicolaou examination for cervical cancer screen. All previous births were by vaginal delivery.
Source: The Journal of Minimally Invasive Gynecology - June 13, 2018 Category: OBGYN Authors: Chung-Yuan Lee, Yeh Giin Ngo, Meng-Chih Lee, Yu-Che Ou, Chin-Jung Wang Source Type: research
