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A case ‐control study and meta‐analysis reveal the association between COX‐2 G‐765C polymorphism and primary end‐stage hip and knee osteoarthritis
ConclusionOur findings suggest that the COX‐2 G‐765C polymorphism exerts a protective effect against primary end‐stage knee osteoarthritis in a female Chinese Han population. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 17, 2018 Category: Laboratory Medicine Authors: Wei Huang, Chen Deng, Feng Tian, Weilu Gao, Zhenfei Ding, Xianliang Rao, Zongsheng Yin Tags: RESEARCH ARTICLE Source Type: research

Preclinical evaluation of a semi ‐automated and rapid commercial electrophoresis assay for von Willebrand factor multimers
ConclusionsThe VWF multimer assay by Sebia is easy to perform and can be successfully implemented in any clinical laboratory for second‐stage evaluation of VWD. The resolution power of multimer distribution is adequate to correctly classify VWD types 1, 2A, 2B, and 3. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 17, 2018 Category: Laboratory Medicine Authors: Marika Pikta, Galina Zemtsovskaja, Hector Bautista, Georges Nouadje, Timea Szanto, Margus Viigimaa, Valdas Banys Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 14, 2018 Category: Laboratory Medicine Tags: ISSUE INFORMATION Source Type: research

Plasma CXCL1 levels and TRAF3IP2 variants in patients with myocardial infarction
BackgroundIL‐17A plays an important role in inflammatory responses in myocardial infarction (MI). IL‐17A signals through its receptor, for which, Act1 (TRAF3IP2) functions as a key upstream adaptor in the pathway. AimTo compare frequencies of functional polymorphisms of TRAF3IP2 (rs13210247, rs33980500) between patients with MI and healthy controls. MethodsThe selected SNPs were studied in 201 Iranian MI patients and 201 healthy blood donors from Fars Province by PCR‐RFLP in association with clinicopathologic criteria of patients. CXCL1 plasma levels in 126 MI patients and 50 normal subjects were measured by ELISA. R...
Source: Journal of Clinical Laboratory Analysis - February 12, 2018 Category: Laboratory Medicine Authors: Safoora Pordel, Mahdi Sajedi Khanian, Mohammad Hossein Karimi, Hossein Nikoo, Mehrnoosh Doroudchi Tags: RESEARCH ARTICLE Source Type: research

Validation of daily urinary creatinine excretion measurement by muscle ‐creatinine equivalence
ConclusionThe increase in %D corresponds to a reduced correlation between muscle mass and creatinine excretion, which indicated a poor performance in the measurement of the 24hUCrE. For studies on single individuals, where small variations in 24hUCrE could be significant, a %D up to 12.6% is suggested; on the other hand, a wider %D interval could be acceptable for population studies. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 9, 2018 Category: Laboratory Medicine Authors: Roberto Iacone, Lanfranco D'Elia, Bruna Guida, Antonio Barbato, Clelia Scanzano, Pasquale Strazzullo Tags: RESEARCH ARTICLE Source Type: research

HER2 Ile655Val polymorphism is negatively associated with breast cancer susceptibility
ConclusionAlthough this polymorphism did not demonstrate potential as a prognostic marker, it may be a suitable susceptibility marker for BC. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 8, 2018 Category: Laboratory Medicine Authors: Felipe Campos Almeida, Bruna Karina Banin Hirata, Carolina Batista Ariza, Roberta Losi Guembarovski, Karen Braj ão Oliveira, Karen Mayumi Suzuki, Alda Losi Guembarovski, Julie Massayo Maeda Oda, Glauco Akelinghton Freire Vitiello, Maria Angelica Ehara Wa Tags: RESEARCH ARTICLE Source Type: research

Genetic and phenotypic characterizations of drug ‐resistant Mycobacterium tuberculosis isolates in Cheonan, Korea
ConclusionPreviously published data on antibiotic resistance genes are insufficient for effective prevention of multidrug‐ or extensive drug‐resistant TB. Additional studies are needed to characterize the complement of antibiotic resistance genes in MTB. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 3, 2018 Category: Laboratory Medicine Authors: Jae ‐Sik Jeon, Jae Kyung Kim, Qute Choi, Jong Wan Kim Tags: RESEARCH ARTICLE Source Type: research

Interference of in vitro hemolysis complete blood count
ConclusionThis study demonstrated that in vitro hemolysis can decrease the clinical and analytical reliability of the assessment of the blood count. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 3, 2018 Category: Laboratory Medicine Authors: Gabriela Jonge, Talita L. Santos, Bruno R. Cruz, Mackelly Simionatto, Jeanine I. M. Bittencourt, Everson A. Krum, Mariane F. Moss, Danielle Cristyane K. Borato Tags: RESEARCH ARTICLE Source Type: research

Evaluation of a recombinant multiepitope antigen for diagnosis of hepatitis C virus: A lower cost alternative for antigen production
ConclusionThe multiepitope protein used here has a lower cost compared to production of each antigen separately and could be an alternative for the serological diagnosis of hepatitis C. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 1, 2018 Category: Laboratory Medicine Authors: Ronaldo Luis Thomasini, Hortencia Gisele Amaro Souza, Oscar Bruna ‐Romero, Antonio Helvecio Totola, Neiva Sellan Lopes Gonçales, Cristiano Xavier Lima, Mauro Martins Teixeira Tags: RESEARCH ARTICLE Source Type: research

Corrigendum
(Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - February 1, 2018 Category: Laboratory Medicine Tags: CORRIGENDUM Source Type: research

Impact of glucose and lipid markers on the correlation of calculated and enzymatic measured low ‐density lipoprotein cholesterol in diabetic patients with coronary artery disease
Background and AimsLow‐density lipoprotein cholesterol (LDL‐C) is widely estimated by Friedewald equation (FE) and Enzymatic test (ET), which are affected by several factors. The aim of this study was to observe the impact of diabetic lipid and glucose patterns on the correlation between FE LDL‐C (F‐LDL) and ET LDL‐C (E‐LDL) in patients with coronary artery disease (CAD). Methods and ResultsA total of 8155 CAD patients were consecutively enrolled and their lipid profiles were measured. The impacts of triglyceride (TG), glycosylated hemoglobin A1c (HbA1c), and high‐density lipoprotein cholesterol (HDL‐C) on ...
Source: Journal of Clinical Laboratory Analysis - January 30, 2018 Category: Laboratory Medicine Authors: Qiu ‐Ting Dong, Ying Gao, Na‐Qiong Wu, Yuan‐Lin Guo, Cheng‐Gang Zhu, Sha Li, Hui‐Hui Liu, Ye‐Xuan Cao, Hui‐Wen Zhang, Xi Zhao, Geng Liu, Qian Dong, Jian‐Jun Li Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 21, 2018 Category: Laboratory Medicine Tags: ISSUE INFORMATION Source Type: research

Useful information provided by graphic displays of automated cell counter in hematological malignancies
ConclusionIt is suggested that the laboratories using the hematology analyzers be aware of graphic display patterns in addition to flaggings generated which provide additional information and give clue toward the diagnosis even before peripheral smear examination. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 21, 2018 Category: Laboratory Medicine Authors: Monica Gupta, Kriti Chauhan, Tanvi Singhvi, Manisha Singh, Rajesh Kumar Grover Tags: RESEARCH ARTICLE Source Type: research

Genetic analysis of interleukin 18 gene polymorphisms in alopecia areata
ConclusionThe rs1946518 (−607C>A) and rs187238 (−137G>C) polymorphisms were found associated with alopecia areata disease. The study suggests that IL‐18 rs187238 and rs1946518 SNPs may be the cause of the AA susceptibility. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 18, 2018 Category: Laboratory Medicine Authors: Sumeyya Deniz Celik, Omer Ates Tags: RESEARCH ARTICLE Source Type: research

Determination of vitamins K1, MK ‐4, and MK‐7 in human serum of postmenopausal women by HPLC with fluorescence detection
ConclusionNew HPLC method for the determination of vitamins K1, MK‐4, and MK‐7 in serum was evaluated and validated. This method is highly specific and sensitive with the low limit of quantification. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 15, 2018 Category: Laboratory Medicine Authors: Eva Klapkova, Jana Cepova, Katerina Dunovska, Richard Prusa Tags: RESEARCH ARTICLE Source Type: research

Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer
BackgroundRecent studies have revealed that circular RNAs are involved in the biological process of some kinds of human cancers. However, little is known about their diagnostic values and functions in colorectal cancer (CRC). MethodsThe expression levels of hsa_circ_0000567 in 102 paired CRC tissues and adjacent noncancerous tissues, 5 CRC cell lines, and a normal colorectal epithelial cell line were detected by quantitative real‐time polymerase chain reaction (qRT‐PCR). The correlations between hsa_circ_0000567 expression levels and the clinicopathological factors of patients with CRC were analyzed. Furthermore, the l...
Source: Journal of Clinical Laboratory Analysis - January 15, 2018 Category: Laboratory Medicine Authors: Jianjun Wang, Xiaomin Li, Linming Lu, Lei He, Haoran Hu, Zengxiang Xu Tags: RESEARCH ARTICLE Source Type: research

Association between SMAD3 gene rs12901499 polymorphism and knee osteoarthritis in a Chinese population
ConclusionIn conclusion, SMAD3 rs12901499 polymorphism may be involved in the development of knee OA. Larger studies with more diverse ethnic populations are needed to confirm these results. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 8, 2018 Category: Laboratory Medicine Authors: Li Zhang, Limin Zhang, Haiqin Zhang, Wenjun Wang, You Zhao Tags: RESEARCH ARTICLE Source Type: research

Manual versus automated streaking system in clinical microbiology laboratory: Performance evaluation of Previ Isola for blood culture and body fluid samples
ConclusionWe demonstrated that the Previ Isola showed high concordance with the manual method in the inoculation of various body fluids, especially in blood culture sample. The use of Previ Isola in clinical microbiology laboratories is expected to save considerable time and human resources. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 4, 2018 Category: Laboratory Medicine Authors: Qute Choi, Hyun Jin Kim, Jong Wan Kim, Gye Cheol Kwon, Sun Hoe Koo Tags: RESEARCH ARTICLE Source Type: research

Clinical and hematological data to group different chronic kidney disease patients: A practical approach to establish different groups of patients
ConclusionA simple two‐parameter‐based stratification strategy could be used to design effective immunological therapies that differentiate the degrees of immuno‐suppression across groups of patients with CKD. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 4, 2018 Category: Laboratory Medicine Authors: Vin ícius B. Péterle, Jéssica de O. Souza, Fernanda de O. Busato, Frederico J. Eutrópio, Gisele de A. P. Costa, David N. Olivieri, Carlos E. Tadokoro Tags: BRIEF REPORT Source Type: research

Comparison of L ‐selectin blood level and gene polymorphism in tuberculosis patients with healthy individuals
ConclusionTB patients had a significantly higher serum L‐selectin level, compared to the controls. Based on the findings, the incidence of TB and L‐selectin polymorphism in the Phe206Leu gene had no significant association. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Peyman Eini, Maria Shirvani, Mehrdad Hajilooi, Farzaneh Esna ‐Ashari Tags: RESEARCH ARTICLE Source Type: research

Analysis of SLCO1B1 and APOE genetic polymorphisms in a large ethnic Hakka population in southern China
ConclusionsWe analyzed the SLCO1B1 and APOE gene polymorphisms in the Hakka population of southern China. This study provides a reference for the individualized meditation for Hakka population in this area. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Zhixiong Zhong, Heming Wu, Bin Li, Cunren Li, Zhidong Liu, Min Yang, Qifeng Zhang, Wei Zhong, Pingsen Zhao Tags: RESEARCH ARTICLE Source Type: research

Evaluation of vitamin D receptor gene polymorphisms (Fok ‐I and Bsm‐I) in T1DM Saudi children
ConclusionThis study emphasizes a positive association between SNPs (Fok‐I and Bsm‐I) and T1DM among Saudi children with increased risk with the Fok‐I F and Bsm‐I b alleles. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Rabab Ali, Iman Fawzy, Ihsan Mohsen, Ahmad Settin Tags: RESEARCH ARTICLE Source Type: research

CYP2C19 and ABCB1 genetic polymorphisms correlate with the recurrence of ischemic cardiovascular adverse events after clopidogrel treatment
ConclusionCYP2C19*3 polymorphism could be an important predictive factor of HPR and ischemic cardiovascular adverse events after clopidogrel treatment. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Xumin Hou, Wenzheng Han, Qian Gan, Yuan Liu, Weiyi Fang Tags: RESEARCH ARTICLE Source Type: research

Maternal thyroid ‐stimulating hormone reference ranges for first trimester screening from 11 to 14 weeks of gestation
BackgroundTo establish maternal thyroid‐stimulating hormone (TSH) reference ranges for first trimester screening from 11 + 0 to 13 + 6 weeks of gestation. MethodsA total of 10 592 singleton and 201 twin consecutive Caucasian pregnant women who underwent simultaneously prenatal first trimester Down's syndrome screening and thyroid function screening from January 2010 to November 2017 were included in the study. Women with positive antithyroid peroxidase antibody (TPOAb) and positive personal history of thyroid disease were previously excluded. TSH was measured by immunochemiluminescent assay ...
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Tom áš Šálek, Ishraq Dhaifalah, Dagmar Langova, Jana Havalová Tags: RESEARCH ARTICLE Source Type: research

Opposite impact of Methylene tetrahydrofolate reductase C677T and Methylene tetrahydrofolate reductase A1298C gene polymorphisms on systemic inflammation
ConclusionsThis study indicates that MTHFR C677T and MTHFR A1298C gene polymorphisms have opposite effect on systemic inflammation, and systemic inflammation may contribute to the pathogenesis for diseases associated with MTHFR C667T gene polymorphism. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Koroush Khalighi, Gang Cheng, Seyedabbas Mirabbasi, Bahar Khalighi, Yin Wu, Wuqiang Fan Tags: RESEARCH ARTICLE Source Type: research

A multilateral investigation of the effects of zinc level on pregnancy
ConclusionBased on the results of this study, it is suggested that zinc supplementation may be an appropriate treatment for the pregnant women with low zinc levels to provide the realization of live births. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Özgül Özgan Çelikel, Özlem Doğan, Nurkan Aksoy Tags: RESEARCH ARTICLE Source Type: research

Diagnostic validity of flow cytometry vs manual counting of polymorphonuclear leukocytes in spontaneous bacterial peritonitis
BackgroundSpontaneous bacterial peritonitis (SBP) is frequently occurring infection among patients with liver cirrhosis, defined by polymorphonuclear (PMN) leukocytic count ≥250 cell/mm3 with or without a positive ascitic fluid (AF) bacterial culture. So, this study aimed to investigate the diagnostic value of flow cytometry versus manual counting of ascitic fluid PMNL in cirrhotic patients, with clinical suspicion of SBP. MethodsA hospital‐based cross‐sectional study was carried out on 320 cirrhotic patients with clinical suspicion of SBP. Abdominal paracentesis was performed in all cases for microscopic manua...
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Heba Ahmed Osman, Sanaa Shaker Aly, Eman M. Salah ‐Eldin, Muhammad Abbas El‐Masry, Mohammed H. Hassan Tags: RESEARCH ARTICLE Source Type: research

A novel cell line generated using the CRISPR/Cas9 technology as universal quality control material for KRAS G12V mutation testing
ConclusionThe novel KRAS G12V cell line generated using the CRISPR/Cas9 gene editing system is suitable as a quality control material for all current detection methods and provides a new direction in the development of quality control material. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Shiyu Jia, Rui Zhang, Guigao Lin, Rongxue Peng, Peng Gao, Yanxi Han, Yu Fu, Jiansheng Ding, Qisheng Wu, Kuo Zhang, Jiehong Xie, Jinming Li Tags: RESEARCH ARTICLE Source Type: research

The association between serum testosterone and mortality among elderly men on hemodialysis
ConclusionsTotal testosterone value was a predictor for mortality. It was noninferior to SMMI in predicting dialysis mortality. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Hung ‐Chieh Wu, Lin‐Chien Lee, Wei‐Jie Wang Tags: RESEARCH ARTICLE Source Type: research

Molecular characterization of diarrheagenic Escherichia coli pathotypes: Association of virulent genes, serogroups, and antibiotic resistance among moderate ‐to‐severe diarrhea patients
ConclusionComprehensive molecular characterization of DEC pathotypes, their incidence estimates, and antibiogram patterns will help in ascertaining better diagnostic and therapeutic measures in management of diarrheal diseases. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - January 1, 2018 Category: Laboratory Medicine Authors: Nutan Thakur, Swapnil Jain, Harish Changotra, Rahul Shrivastava, Yashwant Kumar, Neelam Grover, Jitendraa Vashistt Tags: RESEARCH ARTICLE Source Type: research

Association of polymorphism in the VEGFA gene 3 ′‐UTR +936T/C with susceptibility to biliary atresia in a Southern Chinese Han population
ConclusionThese results suggest that VEGFA gene polymorphism (rs3025039) may not be associated with the risk of BA in the Southern Chinese Han population. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - December 18, 2017 Category: Laboratory Medicine Authors: Fei Liu, Jixiao Zeng, Deli Zhu, Ruizhong Zhang, Xiaogang Xu, Mengmeng Wang, Yan Zhang, Huimin Xia, Zhichun Feng Tags: RESEARCH ARTICLE Source Type: research

After neoadjuvant chemotherapy platelet/lymphocyte ratios negatively correlate with prognosis in gastric cancer patients
ConclusionsPre‐neoadjuvant chemotherapy PLR may be a feasible biomarker for survival prognosis in patients with locally advanced gastric cancer. PLR and NLR were reduced after neoadjuvant chemotherapy. After neoadjuvant chemotherapy, PLR level was negatively correlated with survival prognosis. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - December 18, 2017 Category: Laboratory Medicine Authors: Weipeng Gong, Lei Zhao, Zhaogang Dong, Yu Dou, Yanguo Liu, Chao Ma, Xun Qu Tags: RESEARCH ARTICLE Source Type: research

Association between urine retinol ‐binding protein levels and nonalcoholic fatty liver disease: A cross‐sectional study in Chinese population
ObjectiveThe prevalence of nonalcoholic fatty liver disease (NAFLD) has been rapidly increased, becoming a public health problem worldwide. Our objective was to investigate the association between urine retinol‐binding protein (RBP) and NAFLD in a Chinese population and develop a multivariate logistic regression model for NAFLD prediction. MethodsA total of 317 NAFLD patients and 391 healthy controls were enrolled in this cross‐sectional study based on inclusion and exclusion criteria, from whom fasting urine and blood were collected for further study. Urine RBP level and other parameters were measured and compared bet...
Source: Journal of Clinical Laboratory Analysis - November 30, 2017 Category: Laboratory Medicine Authors: Juanwen Zhang, Zeyu Liu, Xuyao Zhang, Li Zhang, Xi Jin Tags: RESEARCH ARTICLE Source Type: research

Diagnostic value of trait antinuclear antibodies and multiple immunoglobulin production in autoimmune diseases
This study also aims to investigate immunoglobulin production in autoimmune diseases by detecting different antibodies. MethodsThe serum ANA profile of 634 patients with autoimmune diseases was analyzed using the immunoblot method. A specific formula was developed in an effort to calculate the theoretical proportion of monospecific ANA (TPM) in different disease groups. Different IgM, IgG, and IgE variants for several pathologies were detected. ResultsThe observed proportions of monospecific ANAs (OPM) were all lower than the predicted TPM in autoimmune diseases. Polyclonal ANAs were predominant in patients with systemic l...
Source: Journal of Clinical Laboratory Analysis - November 23, 2017 Category: Laboratory Medicine Authors: Liping Wan, Hong Zhu, Yanan Gu, Hui Liu Tags: RESEARCH ARTICLE Source Type: research

Hemolysis and IgA ‐antibodies against tissue transglutaminase: When are antibody test results no longer reliable?
BackgroundAntibodies against tissue transglutaminase (TTG) of isotype IgA (IgA‐aTTG) represent reliable diagnostic markers to confirm or exclude celiac disease (CD). Hemolysis (HL) is an important pre‐analytical factor. HL can be quantified as HL index (HI) correlating with the concentration of free hemoglobin. TTG is abundant in erythrocytes and released upon HL. In immunoassays, the released TTG may interfere with binding of IgA‐aTTG to the coated TTG. MethodsWe selected 17 HL‐free sera from children with biopsy‐confirmed CD: 7 with low‐positive (1‐5 multiples of upper limit of normal [×ULN]), 5 with ...
Source: Journal of Clinical Laboratory Analysis - November 23, 2017 Category: Laboratory Medicine Authors: Johannes Wolf, Norman Haendel, Johannes Remmler, Carl Elias Kutzner, Thorsten Kaiser, Thomas Mothes Tags: RESEARCH ARTICLE Source Type: research

Clinical value of peripheral blood microRNA detection in evaluation of SOX regimen as neoadjuvant chemotherapy for gastric cancer
BackgroundNeoadjuvant chemotherapy has been widely applied in treating advanced gastric cancer (GC). However, little research has been conducted on evaluating the effect of neoadjuvant chemotherapy. Purpose of this study was to evaluate the effect of SOX regimen as neoadjuvant chemotherapy by detecting some microRNAs. MethodsTotal 120 GC patients who had received neoadjuvant chemotherapy (SOX regimen) were recruited with 100 healthy participants as control contemporarily. Age and gender have no significant difference in both groups (P > .05). The effect of chemotherapy was evaluated by the results of CT scan a...
Source: Journal of Clinical Laboratory Analysis - November 23, 2017 Category: Laboratory Medicine Authors: Bibo Tan, Yong Li, Yan Di, Liqiao Fan, Qun Zhao, Qingwei Liu, Dong Wang, Nan Jia Tags: RESEARCH ARTICLE Source Type: research

Issue Information
(Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 22, 2017 Category: Laboratory Medicine Tags: ISSUE INFORMATION Source Type: research

Circulating PCSK9 is lowered acutely following surgery
ConclusionUnlike other studies which showed an increase in PCSK9 after the onset of stress, our study detected a fall in PCSK9 following acute surgical stress. The observed difference is likely due to the earlier timing of PCSK9 measurement in our study. Further studies involving serial poststress measurements for several days are needed to determine whether PCSK9 behaves as an acute‐phase reactant, whether it displays a biphasic response to acute stress, and whether changes in circulating PCSK9 are responsible for lipoprotein changes observed after surgical stress. (Clinical Trial Registration: ClinicalTrials.gov study ...
Source: Journal of Clinical Laboratory Analysis - November 17, 2017 Category: Laboratory Medicine Authors: Irena Druce, Hussein Abujrad, Seham Chaker, Hilary Meggison, Andrew Hill, Angela Raymond, Janice Mayne, Teik Chye Ooi Tags: BRIEF REPORT Source Type: research

Nutrients intake, and serum calcium and phosphorus levels: An evidence ‐based study
ConclusionWe found that the dietary intake of Ca was not sufficient in our population and was associated with the dietary intake of some macro‐ and micronutrient, supporting further investigation on clinical impact of this condition on calcium/phosphorus deficiency related diseases. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 7, 2017 Category: Laboratory Medicine Authors: Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A. Ferns, Majid Ghayour Mobarhan Tags: RESEARCH ARTICLE Source Type: research

Association of interleukin ‐18 gene polymorphism and its protein expression with the lower extremity deep venous thrombosis in the chinese han population: A case‐control study
ConclusionOn the basis of our results, we concluded that the GG genotype of −137G/C polymorphism and IL‐18 level are independent risk factors of LEDVT, and IL‐18 gene polymorphism affects the level of IL‐18 in LEDVT patients. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 4, 2017 Category: Laboratory Medicine Authors: Ye ‐Long Chen, Li‐Hong Shou, Zong‐Xin Zhang Tags: RESEARCH ARTICLE Source Type: research

HLA ‐B27 testing: A journey from flow cytometry to molecular subtyping
ConclusionWe recommend DNA typing as a complementary tool along with flow cytometry to accomplish successful HLA‐B27 phenotype determination. This is the first study among Indian population to evaluate efficacy of EUROArray to detect B27 allele and its potential to indicate the presence of nondisease‐associated alleles in Indian population. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Pratiksha Chheda, Sandeep Warghade, Jyothi Mathias, Tavisha Dama, Sunmeet Matkar, Nilesh Shah, Rajesh Bendre Tags: RESEARCH ARTICLE Source Type: research

Test ‐1 analyzer and conventional Westergren method for erythrocyte sedimentation rate: A comparative study between two laboratories
This study intends to compare ESR levels measured by Test‐1 method and International Council for Standardization in Hematology's (ICSH) reference method, and analyzes the effect of hematocrit (Hct) on ESR results. Material and MethodsA total of 755 patients from 2 hospitals were included in the study, and samples with EDTA were studied by Test‐1 method for ESR measurement and total blood count, whereas citrated samples were studied with reference Westergren method. Then, 2 methods were compared. Distribution of ESR results according to the ESR(≤20,>20 mm/h) and Hct(≥35%,
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Cigdem Sonmez, Ozlem Ceylan Dogan, Aysegul Ozturk Kaymak, Nedim Akkaya, Kadir Okhan Akin, Gulcan Guntas Tags: RESEARCH ARTICLE Source Type: research

Surrogate scale for evaluating respiratory function based on complete blood count parameters
In this study, we aimed to identify a simple method for evaluating respiratory function using complete blood count parameters. MethodsThe complete blood count parameters, including red blood cell (RBC) count, hemoglobin (Hb) level, lymphocyte (Lym) and platelet (Plt) count, and partial pressure of oxygen (PO2) level, were measured using automated analyzers in patients with chronic obstructive pulmonary disease (COPD), aged subjects, and young subjects (control group). The red cell index (RCI) was calculated using the following equation: (RBC × Hb)/(Lym × Plt); in theory, the RCI is inversely...
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Yang Guang, Zhou Jie, Dong Feng, Liu Hui Tags: RESEARCH ARTICLE Source Type: research

Reference intervals of carbohydrate antigen 19 ‐9 in the apparently healthy adult population
BackgroundTo establish reference intervals of carbohydrate antigen 19‐9(CA 19‐9) according to the CLSI CA28‐A3 guideline and to evaluate age‐ and gender‐related variations. MethodsSerum CA 19‐9 values of 10 149 healthy subjects (from 20 years old to 60 years old) were measured from location health checkups. The relationship between CA 19‐9 and age was analyzed using Spearman's approach. The reference intervals of CA19‐9 were established using Q2.5 and Q97.5, and the 90% confidence intervals of upper limits were calculated. ResultsThe reference intervals of CA 19‐9 were 1.98‐25.12 U/mL for...
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Gao ‐Ming Zhang, Shu‐Mei Bai, Guo‐Ming Zhang, Xiao‐Bo Ma Tags: RESEARCH ARTICLE Source Type: research

Red blood cell distribution width as a predictor of atrial fibrillation
BackgroundCurrent evidence suggests that a higher red blood cell distribution width (RDW) may be associated with increased risk of atrial fibrillation (AF) development. Given that some controversial results have been published, we conducted a systematic review of the current literature along with a comprehensive meta‐analysis to evaluate the association between RDW and AF development. MethodsWe performed a systematic search of the literature using electronic databases (PubMed, Ovid, Embase, and Web of Science) to identify studies reporting on the association between RDW and AF development published until June 2016. We us...
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Qingmiao Shao, Panagiotis Korantzopoulos, Konstantinos P. Letsas, Gary Tse, Jiang Hong, Guangping Li, Tong Liu Tags: RESEARCH ARTICLE Source Type: research

Two novel CPS1 mutations in a case of carbamoyl phosphate synthetase 1 deficiency causing hyperammonemia and leukodystrophy
ConclusionThis study described the specific clinical characteristics and the variations of physiological and biochemical indices in a Chinese neonatal patient with CPS1D, which facilitated the diagnosis and mechanism research of the disease. Two novel causative missense mutations were identified, which enriched the mutation spectrum of CPS1D in China and worldwide. Advice of prenatal diagnosis was given to the family for a new pregnancy. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Xihui Chen, Lijuan Yuan, Mao Sun, Qingbo Liu, Yuanming Wu Tags: RESEARCH ARTICLE Source Type: research

Consistency of the Moreau CLL score
ConclusionInconsistencies in the Moreau score are common, supporting the importance of integrated laboratory diagnosis. However, the practical implications of these antigenic inconsistencies are probably limited. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Marc Sorigue, Edurne Sarrate, Mireia Franch ‐Sarto, Evarist Feliu, Jordi Junca Tags: RESEARCH ARTICLE Source Type: research

Correlation between the cell population in the automated hematology analyzer high ‐fluorescence region and atypical lymphocyte flags
ConclusionIt demonstrates that HFCs reflects atypical lymphocytes better than immature lymphocytes/blasts. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Hongjie Xie, Yue Wu, Wei Cui Tags: RESEARCH ARTICLE Source Type: research

Aspartate transaminase to platelet ratio index and gamma ‐glutamyl transpeptidase‐to‐platelet ratio outweigh fibrosis index based on four factors and red cell distribution width‐platelet ratio in diagnosing liver fibrosis and inflammation in chronic hepatitis B
ConclusionAPRI and GPR were more effective than FIB‐4 and RPR at diagnosing liver inflammation and fibrosis. (Source: Journal of Clinical Laboratory Analysis)
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Xiaojuan Wu, Bei Cai, Zhenzhen Su, Yamei Li, Jin Xu, Rong Deng, Lanlan Wang Tags: RESEARCH ARTICLE Source Type: research

Utility of complete blood count parameters to detect premature ovarian insufficiency in cases with oligomenorrhea/amenorrhea
BackgroundThere are very few biomarkers available to diagnose cases with premature ovarian failure. Some complete blood count parameters have been introduced to be diagnostic biomarkers for several disorders associated with inflammatory process. Due to the evidence that indicated chronic inflammatory process to be underlying pathophysiology in premature ovarian insufficiency (POI), we aimed to assess the predictive value of complete blood count parameters for POI diagnosis. MethodA total of 96 women diagnosed to have premature ovarian failure were compared with 110 otherwise healthy women in terms of some basal hormone lev...
Source: Journal of Clinical Laboratory Analysis - November 1, 2017 Category: Laboratory Medicine Authors: Ilhan Sanverdi, Cetin Kilicci, Ebru Cogendez, Cigdem Abide Yayla, Enis Ozkaya Tags: RESEARCH ARTICLE Source Type: research