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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Expression of targets of the RNA-binding protein AUF-1 in human airway epithelium indicates its role in cellular senescence and inflammation
DiscussionLoss of intracellular AUF-1 may alter posttranscriptional regulation of targets particularly relevant for protection of genomic integrity and gene regulation, thus concurring to airway epithelial inflammatory responses related to oxidative stress and accelerated aging. Exosomal-associated AUF-1 may in turn preserve bound RNA targets and sustain their function, participating to spreading of inflammation and senescence to neighbouring cells.
Source: Frontiers in Immunology - July 7, 2023 Category: Allergy & Immunology Source Type: research
Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone
In conclusion, these results are the first to demonstrate that bavachalcone exerts anti-neuroinflammatory and antidepressant effects via inhibition of the NF-κB pathway mediated by upregulating A20 and TAX1BP1, and may be a potential candidate for the treatment of neuroinflammation-related diseases, including depression.PMID:37393841 | DOI:10.1016/j.intimp.2023.110552
Source: International Immunopharmacology - July 2, 2023 Category: Allergy & Immunology Authors: Xintong Wu Zhonghong Zhang Xiao Zhang Yaping Guo Feng Liu Jianwei Gong Li Li Xinyu Chen Zhipeng Li Source Type: research
TNF- α promotes CXCL-1/8 production in keratinocytes by downregulating galectin-3 through NF-κB and hsa-miR-27a-3p pathway to contribute psoriasis development
CONCLUSION: TNF-α initiates psoriatic inflammation by increasing CXCL-1/8 in keratinocytes mediated by the axis of NF-κB-hsa-miR-27a-3p-galectin-3 pathway.PMID:37358143 | DOI:10.1080/08923973.2023.2229510
Source: Immunopharmacology and Immunotoxicology - June 26, 2023 Category: Allergy & Immunology Authors: Xiao-Nan Qiu Dan Hong Zhen-Rui Shi Si-Yao Lu Yu-Xian Lai Yan-Ling Ren Xiu-Ting Liu Chi-Peng Guo Guo-Zhen Tan Liang-Chun Wang Source Type: research
Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis via Mas-related G protein-coupled receptor X2 in mast cells
Mast cell (MC) activation is implicated in the pathogenesis of multiple immunodysregulatory skin disorders. Activation of an IgE-independent pseudo-allergic route has been recently found to be mainly mediated via Mas-Related G protein-coupled receptor X2 (MRGPRX2). Ryanodine receptor (RYR) regulates intracellular calcium liberation. Calcium mobilization is critical in the regulation of MC functional programs. However, the role of RYR in MRGPRX2-mediated pseudo-allergic skin reaction has not been fully addressed. To study the role of RYR in vivo, we established a murine skin pseudo-allergic reaction model. RYR inhibitor att...
Source: Frontiers in Immunology - June 19, 2023 Category: Allergy & Immunology Source Type: research
ATRA ameliorates fibrosis by suppressing the pro-fibrotic molecule Fra2/AP-1 in systemic sclerosis
In this study, the pro-fibrotic effect of Fra2 in SSc is confirmed. SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc animals exhibit increased levels of Fra2. Inhibition of Fra2 expression in SSc dermal fibroblasts with Fra2 siRNA markedly decreased collagen I expression. ATRA reduced the expressions of Fra2, collagen I, and α-smooth muscle actin(α-SMA) in SSc dermal fibroblasts and bleomycin-induced fibrotic tissues of SSc mice. In addition, chromatin immunoprecipitation and dual-luciferase assays demonstrated that retinoic acid receptor RARα binds to the FRA2 promoter and modulates its transcriptio...
Source: International Immunopharmacology - June 18, 2023 Category: Allergy & Immunology Authors: Zixin Pi Jiani Liu Yangfan Xiao Xinglan He Ruixuan Zhu Rui Tang Xiangning Qiu Yi Zhan Zhuotong Zeng Yaqian Shi Rong Xiao Source Type: research
Bombyx mori Tetraspanin A (BmTsp.A) is a facilitator in BmNPV invasion by regulating apoptosis
This study focused on the sequence features, analysis of expression pattern, as well as the effect of BmTsp.A on BmNPV (Bombyx mori nucleopolyhedrovirus) infection in the apoptotic pathway. BmTsp.A features the typical tetraspanins family, including four transmembrane domains and a major large extracellular loop domain. It is highly expressed specifically in the malpighian tubes, and its expression is increased by BmNPV induction for 48 h and 72 h. Overexpression and RNAi (RNA interference) mediated by siRNA reveal that BmTsp.A can promote the infection and replication of the virus. In addition, the overexpression of BmTsp...
Source: Developmental and Comparative Immunology - May 19, 2023 Category: Allergy & Immunology Authors: Xianghan Mei Peitong Qiao Hengheng Ma Siyu Qin Xia Song Qiaoling Zhao Dongxu Shen Source Type: research
CD5L aggravates rheumatoid arthritis progression via promoting synovial fibroblasts proliferation and activity
In conclusion, CD5L promote RA disease progression via activating RASFs. CD5L blocking is a potential therapeutic approach for RA patients.PMID:37191481 | DOI:10.1093/cei/uxad054
Source: Clinical and Developmental Immunology - May 16, 2023 Category: Allergy & Immunology Authors: Xia-Nan Wu Zhao-Wei Gao Lan Yang Juan Zhang Chong Liu Hui-Zhong Zhang Ke Dong Source Type: research
