Upregulation of A20 and TAX1BP1 contributes to the anti-neuroinflammatory and antidepressant effects of bavachalcone

In conclusion, these results are the first to demonstrate that bavachalcone exerts anti-neuroinflammatory and antidepressant effects via inhibition of the NF-κB pathway mediated by upregulating A20 and TAX1BP1, and may be a potential candidate for the treatment of neuroinflammation-related diseases, including depression.PMID:37393841 | DOI:10.1016/j.intimp.2023.110552

Source: International Immunopharmacology - July 2, 2023 Category: Allergy & Immunology Authors: Xintong Wu Zhonghong Zhang Xiao Zhang Yaping Guo Feng Liu Jianwei Gong Li Li Xinyu Chen Zhipeng Li Source Type: research