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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Mettl14 sustains FOXP3 expression to promote the differentiation and functions of induced-regulatory T cells via the mTOR signaling pathway
In conclusion, our study revealed that Mettl14 plays a critical role in the development and suppressive function of iTregs in vitro and could thus serve as a regulatory element for stabilizing iTregs in cell-based therapy.PMID:37121553 | DOI:10.1016/j.imlet.2023.04.008
Source: Immunology Letters - April 30, 2023 Category: Allergy & Immunology Authors: Yanzhuo Liu Yinglin Yuan Zili Zhou Xiaomei Jiang Shu He Fan Wei Yuanyuan Cui Lu Yang Gaoping Zhao Source Type: research
Spermidine protects intestinal mucosal barrier function in mice colitis via the AhR/Nrf2 and AhR/STAT3 signaling pathways
CONCLUSION: Our study demonstrated that spermidine rescues intestinal barrier defects in mice with colitis via the AhR-Nrf2 and AhR-STAT3 pathways, providing a potential therapeutic agent for IBD and other conditions associated with dysregulated gut barrier function.PMID:37104918 | DOI:10.1016/j.intimp.2023.110166
Source: International Immunopharmacology - April 27, 2023 Category: Allergy & Immunology Authors: Bing Yan Xinjie Mao Shasha Hu Shimin Wang Xiaochen Liu Jing Sun Source Type: research
Downregulation of ROR2 attenuates LPS ‐induced A549 cell injury through JNK and ERK signaling pathways
ConclusionsThus, the present data indicate that downregulation of ROR2 may decrease LPS-induced inflammatory responses and cell apoptosis through inhibiting JNK and ERK signaling pathway, which attenuates ALI.
Source: Immunity, Inflammation and Disease - April 26, 2023 Category: Allergy & Immunology Authors: Zhonglin Wang,
Liu Yang Tags: ORIGINAL ARTICLE Source Type: research
Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway
CONCLUSIONS: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.PMID:37075800
Source: Allergy, Asthma and Immunology Research - April 19, 2023 Category: Allergy & Immunology Authors: Lijuan Du Changyi Xu Kun Tang Jia Shi Lu Tang Xiao Lisha Chengcheng Lei Huicong Liu Yuxia Liang Yubiao Guo Source Type: research
TLR3 recognition of viral double-stranded RNA in human dental pulp cells is important for the innate immunity
Int Immunopharmacol. 2023 Apr 13;119:110161. doi: 10.1016/j.intimp.2023.110161. Online ahead of print.ABSTRACTDental caries or trauma can expose human dental pulp cells (DPCs) to various oral microorganisms, which play an important role in the development of an innate immune response. In the present study, we examined the expression of Toll-like receptors (TLRs) for sensing microbe-associated molecular patterns in human DPCs. Interestingly, real-time PCR analysis demonstrated that TLR3 is the most highly expressed among 10 different TLRs in human DPCs. Poly(I:C), a representative TLR3 ligand mimicking viral double-stranded...
Source: International Immunopharmacology - April 15, 2023 Category: Allergy & Immunology Authors: Ye-Eun Ha Yoon Ju So Jintaek Im Cheol-Heui Yun Joo-Cheol Park Seung Hyun Han Source Type: research
