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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Correction: IFN- γ-Primed Macrophages Exhibit Increased CCR2-Dependent Migration and Altered IFN-γ Responses Mediated by Stat1
J Immunol. 2023 Feb 24:ji2300060. doi: 10.4049/jimmunol.2300060. Online ahead of print.ABSTRACTDue to an error in figure preparation, incorrect Stat1 and Stat3 panels were included in Fig. 4A. The corrected version of Fig. 4 is shown below. A corrected version of the legend for Fig. 4 indicating the splicing in Fig. 4A is also shown below. FIGURE 4. Stat3 mediates IFN-γ activation of certain Stat1-independent genes. A, THP-1 cells were transduced with lentiviral particles encoding DSred2 small interfering RNA (siRNA) or Stat3 siRNA. Cell lysates from lentiviral-transduced THP-1 cells were subjected to immunoblotting. Inte...
Source: Journal of Immunology - March 8, 2023 Category: Allergy & Immunology Authors: Xiaoyu Hu Kyung-Hyun Park-Min Hao H Ho Lionel B Ivashkiv Source Type: research
Human papillomavirus in the setting of immunodeficiency: Pathogenesis and the emergence of next-generation therapies to reduce the high associated cancer risk
Human papillomavirus (HPV), a common sexually transmitted virus infecting mucosal or cutaneous stratified epithelia, is implicated in the rising of associated cancers worldwide. While HPV infection can be cleared by an adequate immune response, immunocompromised individuals can develop persistent, treatment-refractory, and progressive disease. Primary immunodeficiencies (PIDs) associated with HPV-related disease include inborn errors of GATA, EVER1/2, and CXCR4 mutations, resulting in defective cellular function. People living with secondary immunodeficiency (e.g. solid-organ transplants recipients of immunosuppression) an...
Source: Frontiers in Immunology - March 7, 2023 Category: Allergy & Immunology Source Type: research
Low-dose ketamine inhibits neuronal apoptosis and neuroinflammation in PC12 cells via α7nAChR mediated TLR4/MAPK/NF-κB signaling pathway
Int Immunopharmacol. 2023 Feb 24;117:109880. doi: 10.1016/j.intimp.2023.109880. Online ahead of print.ABSTRACTKetamine is commonly used for sedation, analgesia and anesthetics. Much evidence has shown that it has an immune-regulatory effect. The cholinergic anti-inflammatory pathway mediated by α7nAChR is a prominent target of anti-inflammatory therapy. However, whether ketamine suppresses inflammatory levels in nerve cells by activating α7nAChR remains unknown. Lipopolysaccharide (LPS) was used to establish the neuroinflammation model in PC12 cells in vitro, and α7nAChR siRNA was transfected into PC12 cells 30 min befo...
Source: International Immunopharmacology - February 26, 2023 Category: Allergy & Immunology Authors: Jinghua Zhao Ruxin Zhang Wei Wang Sheng Jiang Huimei Liang Chen Guo Jingyi Qi Huan Zeng Houhui Song Source Type: research
Anti-inflammatory role of extracellular l-arginine through calcium sensing receptor in human renal proximal tubular epithelial (HK-2) cells
Int Immunopharmacol. 2023 Feb 22;117:109853. doi: 10.1016/j.intimp.2023.109853. Online ahead of print.ABSTRACTRenal tubular epithelial cells are capable of synthesizing interleukins (IL) in response to a variety of proinflammatory cytokines. Moreover, elevated urinary levels of IL have been shown in patients with various forms of nephritic diseases. However, the underlying intracellular signaling mechanism is unclear. Here we show the immunological signaling role of l-Arginine (l-Arg) through Ca2+-sensing receptor (CaSR) in human kidney 2 (HK-2) renal proximal tubular epithelial cells, using Ca2+ imaging and patch clamp te...
Source: International Immunopharmacology - February 24, 2023 Category: Allergy & Immunology Authors: Samuel Shin Eugenia Awuah Boadi Saloni Shah Madison Ezell Peijun Li Bidhan C Bandyopadhyay Source Type: research
CXCL9, 10, 11/CXCR3 Axis Contributes to the Progress of Primary Sjogren ’s Syndrome by Activating GRK2 to Promote T Lymphocyte Migration
AbstractPrimary Sjogren ’s syndrome (pSS) is a systemic autoimmune disease that causes dysfunction of secretory glands and the specific pathogenesis is still unknown. The CXCL9, 10, 11/CXCR3 axis and G protein-coupled receptor kinase 2 (GRK2) involved in many inflammation and immunity processes. We used NOD/Ltj mice, a s pontaneous SS animal model, to elucidate the pathological mechanism of CXCL9, 10, 11/CXCR3 axis promoting T lymphocyte migration by activating GRK2 in pSS. We found that CD4 + GRK2, Th17 + CXCR3 was apparently increased and Treg + CXCR3 was significantly decreased in the spleen of 4W NOD mice...
Source: Inflammation - February 18, 2023 Category: Allergy & Immunology Source Type: research
PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage
In this study, SAH mouse models were assigned to treat with scramble or PHLDA1 small interfering RNAs (siRNAs). We observed that PHLDA1 was significantly increased and mainly distributed in microglia after SAH. Concomitant with PHLDA1 activation, nod-like receptor pyrin domain-containing protein 3 (NLRP3) inflammasome expression in microglia was also evidently enhanced after SAH. In addition, PHLDA1 siRNA treatment significantly reduced microglia-mediated neuroinflammation by inhibiting M1 microglia and promoting M2 microglia polarization. Meanwhile, PHLDA1 deficiency reduced neuronal apoptosis and improved neurological ou...
Source: Frontiers in Immunology - February 17, 2023 Category: Allergy & Immunology Source Type: research
Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage
In conclusion, the present study demonstrates that decreased ERα expression promotes macrophage infiltration and plaque instability in the postmenopausal stage, and activation of ERα in the postmenopausal stage alleviates atherosclerotic plaque instability by inhibiting TLR4 signaling and macrophage-related inflammation.PMID:36764277 | DOI:10.1016/j.intimp.2023.109825
Source: International Immunopharmacology - February 10, 2023 Category: Allergy & Immunology Authors: Qinghai Meng Yunhui Bi Han Feng Xue Ding Shurui Zhang Qi Chen Liang Wang Qichun Zhang Yu Li Huangjin Tong Lixing Wu Huimin Bian Source Type: research
Lnc-AIFM2-1 promotes HBV immune escape by acting as a ceRNA for miR-330-3p to regulate CD244 expression
Chronic hepatitis B (CHB) virus infection is a major risk factor for cirrhosis and hepatocellular carcinoma (HCC). Hepatitis B virus (HBV) immune escape is regulated by the exhaustion of virus-specific CD8+ T cells, which is associated with abnormal expression of negative regulatory molecule CD244. However, the underlying mechanisms are unclear. To investigate the important roles of non-coding RNAs play in CD244 regulating HBV immune escape, we performed microarray analysis to determine the differential expression profiles of long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and mRNAs in patients with CHB and patients wi...
Source: Frontiers in Immunology - February 9, 2023 Category: Allergy & Immunology Source Type: research
Engineered NF- κB siRNA-encapsulating exosomes as a modality for therapy of skin lesions
DiscussionOverall, this study establishes a feasible therapeutic strategy for skin injury, which may offer an alternative to conventional biological therapies requiring two or more independent compounds.
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
Vitamin D3 alleviates inflammation in ulcerative colitis by activating the VDR-NLRP6 signaling pathway
In this study, we carried out histological and physiological analyses in UC patients and UC mice. RNA sequencing (RNA-seq), assays for transposase-accessible chromatin with high-throughput sequencing (ATAC-seq), chromatin immunoprecipitation (ChIP) assays and protein and mRNA expression were performed to analyze and identify the potential molecular mechanism in UC mice and lipopolysaccharide (LPS)-induced mouse intestinal epithelial cells (MIECs). Moreover, we established nucleotide-binding oligomerization domain (NOD)-like receptor protein nlrp6-/- mice and siRNA-NLRP6 MIECs to further characterize the role of NLRP6 in an...
Source: Frontiers in Immunology - February 8, 2023 Category: Allergy & Immunology Source Type: research
Integrated analysis of ATAC-seq and RNA-seq reveals the transcriptional regulation network in SLE
CONCLUSION: These DARs associated with this disease may become targets for future treatment of SLE.PMID:36738683 | DOI:10.1016/j.intimp.2023.109803
Source: International Immunopharmacology - February 4, 2023 Category: Allergy & Immunology Authors: Jiali Wu Yuwei Li Delong Feng Yaqin Yu Haojun Long Zhi Hu Qianjin Lu Ming Zhao Source Type: research
Caveolin-1 ameliorates acetaminophen-aggravated inflammatory damage and lipid deposition in non-alcoholic fatty liver disease via the ROS/TXNIP/NLRP3 pathway
Int Immunopharmacol. 2023 Jan;114:109558. doi: 10.1016/j.intimp.2022.109558. Epub 2022 Dec 21.ABSTRACTThe overuse of acetaminophen (APAP) may cause more severe hepatotoxicity in patients with non-alcoholic fatty liver disease (NAFLD). Caveolin-1 (CAV1), is an essential regulator of metabolic function, which can alleviate liver damage by scavenging reactive oxygen species (ROS). Evidence suggests that the NOD-like receptor family pyrin domain-containing 3 (NLRP3) -mediated pyroptosis is involved in the development of NAFLD. Moreover, thioredoxin-interactive protein (TXNIP) activation is a key event linking ROS to NLRP3 infl...
Source: International Immunopharmacology - January 26, 2023 Category: Allergy & Immunology Authors: Xiangfu Jiang Yu Li Dongdong Fu Tingyu You Shuai Wu Jiao Xin Jiagen Wen Yan Huang Chengmu Hu Source Type: research
