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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Sp1 Controls the Basal Level of Interleukin-34 Transcription
Immunol Invest. 2022 Dec 23:1-17. doi: 10.1080/08820139.2022.2157283. Online ahead of print.ABSTRACTInterleukin-34 (IL-34) is a cytokine that plays important roles at steady state and in diseases. The induced or inhibited expression of IL-34 by stimuli has been deeply investigated. However, the regulation of IL-34 basal expression is largely unknown. The aim of this study is to investigate whether IL-34 expression is regulated by a general transcription factor Specificity Protein 1 (Sp1) at transcription level. By using bioinformatic software, four putative Sp1-binding sites overlapping GC boxes were found in the core prom...
Source: Immunological Investigations - December 23, 2022 Category: Allergy & Immunology Authors: Minggui Lin Xingyun Liu Xinhui Zhang Huimin Wang Yu Fang Xiaoting Wu Anqi Yin Wanqing Yang Dong Zhang Miaomiao Li Ling Zhang Songcheng Ying Source Type: research
Neuroblast Differentiation-Associated Protein Derived Polypeptides: AHNAK(5758-5775) Induces Inflammation by Activating Mast Cells via ST2
This study aimed to investigate whether AHNAK (5758-5775), a neuroblast differentiation-associated protein-derived polypeptide, could be considered a new endogenous substance in psoriasis patients, which activates mast cells and induces the skin inflammatory response contributing to psoriasis. Wild-type mice were treated with AHNAK(5758-5775) to observe the infiltration of inflammatory cells in the skin and cytokine release in vivo. The release of inflammatory mediators by mouse primary mast cells and the laboratory of allergic disease 2 (LAD2) human mast cells was measured in vitro. Molecular docking analysis, molecular d...
Source: Immunological Investigations - December 13, 2022 Category: Allergy & Immunology Authors: Xiangjin Song Lei Zhang Xueshan Du Yi Zheng Tao Jia Tong Zhou Delu Che Songmei Geng Source Type: research
Tartrate resistant acid phosphatase 5 (TRAP5) mediates immune cell recruitment in a murine model of pulmonary bacterial infection
In this study, we found that Trap5-/- mice had impaired clearance of P. aeruginosa airway infection and reduced recruitment of immune cells (i.e. neutrophils and inflammatory macrophages). Trap5 knockdown using siRNA resulted in a decreased activation of the proinflammatory transcription factor NF-κB in reporter mice and a subsequent decrease of proinflammatory gene expression. Add-back experiments of enzymatically active TRAP5 to Trap5-/- mice restored immune cell recruitment and bacterial killing. In human CF lung tissue, TRAP5 of alveolar macrophages was detected in proximity to OPN to a higher degree than in normal lu...
Source: Frontiers in Immunology - December 8, 2022 Category: Allergy & Immunology Source Type: research
The CARDS toxin of Mycoplasma pneumoniae induces a positive feedback loop of type 1 immune response
ConclusionsOur findings suggest that CARDS toxin induces a type 1 immune response positive feedback loop during M. pneumoniae infection; this putative mechanism may be useful in future investigations of immune intervention approaches for M. pneumoniae pneumonia.
Source: Frontiers in Immunology - December 1, 2022 Category: Allergy & Immunology Source Type: research
Toll-interacting protein negatively regulated innate immune response via NF- κB signal pathway in blunt snout bream, Megalobrama amblycephala
Dev Comp Immunol. 2022 Nov 22:104595. doi: 10.1016/j.dci.2022.104595. Online ahead of print.ABSTRACTToll-interacting protein (Tollip) is an important negative regulator of Toll-like receptor-mediated innate immunity by preventing excessive proinflammatory responses. The structure and function of Tollip have been well identified in mammals, but the piscine Tollip remains poorly understood. In the present study, a homologue of Tollip was identified and characterized from blunt snout bream (named MaTollip), which was composed of an 831 bp open reading frame encoding a protein of 276 amino acids. Phylogenetic analysis indicate...
Source: Developmental and Comparative Immunology - November 25, 2022 Category: Allergy & Immunology Authors: Wenjun Wang Yang Liu Ying Mao Yandong Xu Zuzhen Wang Ru Zhang Bing Liu Kuanyu Xia Moci Yang Jinpeng Yan Source Type: research
Nectin4 is a potential therapeutic target for asthma
ConclusionThese results suggest that Nectin4 is involved in airway inflammation and may be a therapeutic target in patients with asthma.
Source: Frontiers in Immunology - November 15, 2022 Category: Allergy & Immunology Source Type: research
Synergistic regulation of microglia differentiation by CD93 and integrin β1 in the rat pneumococcal meningitis model
In conclusion, interaction between integrin β1 and CD93 promotes differentiation of microglia to the M1 phenotype, increases the release of pro-inflammatory factors, and leads to nervous system injury in pneumococcal meningitis.PMID:36336138 | DOI:10.1016/j.imlet.2022.11.001
Source: Immunology Letters - November 6, 2022 Category: Allergy & Immunology Authors: Nana Qiao Jinghui Zhang Ya Zhang Xinjie Liu Source Type: research
