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Specialty: Allergy & Immunology
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Total 1296 results found since Jan 2013.
Increased CYR61 expression activates CCND1/c-Myc pathway to promote nasal epithelial cells proliferation in chronic rhinosinusitis with nasal polyps
CONCLUSIONS: CYR61, CCND1 and c-Myc were primarily expressed by epithelial cells in nasal mucosa. CYR61, CCND1 and c-Myc expression levels were increased in CRSwNP compared with controls. CYR61 could interact with ITGA2 to enhance HNEC proliferation via upregulating CCND1 and c-Myc levels in the HNEC, leading to hyperplastic nasal epithelium in CRSwNP.PMID:36681101 | DOI:10.1016/j.clim.2023.109235
Source: Clinical Immunology - January 21, 2023 Category: Allergy & Immunology Authors: Chunyu Luo Ying Zhu Jiayao Zhou Xiwen Sun Shiyao Zhang Shaolin Tan Zhipeng Li Hai Lin Weitian Zhang Source Type: research
BAFF Promotes FLS Activation Through BAFFR-Mediated Non-canonical NF- κB Pathway and the Effects of CP-25
In this study, we aimed to understand the mechanism by which BAFF activates FLS and the effect of CP-25 on FLS function. Therefore, the proliferation and migration abilities of FLS and key proteins on the non-canonical NF- κB pathway were examined. The results showed that compared with the FLS of normal rats/OA patients, the expression of BAFF-R, TRAF2, NIK, p-IKKα, P100, and P52 was higher in the FLS of AA rats/RA patients, while the expression of TRAF3 was lower. And, BAFF promotes FLS activation by activating the non-canonical NF-κB signaling pathway. Meanwhile, BAFFR-siRNA inhibited the proliferation of FLS and the ...
Source: Inflammation - January 16, 2023 Category: Allergy & Immunology Source Type: research
Dimethyl fumarate ameliorates fungal keratitis by limiting fungal growth and inhibiting pyroptosis
CONCLUSION: DMF limits fungal growth by suppressing biofilm formation, conidial adherence and respiratory metabolism. It also exerts an anti-inflammatory effect on fungal keratitis by inhibiting pyroptosis, which could be regulated by Nrf2. Our results suggest that DMF plays a therapeutic role in fungal keratitis.PMID:36641891 | DOI:10.1016/j.intimp.2023.109721
Source: International Immunopharmacology - January 15, 2023 Category: Allergy & Immunology Authors: Lingwen Gu Jing Lin Qian Wang Lina Zhang Min Yin Hao Lin Hengrui Zheng Guiqiu Zhao Cui Li Source Type: research
B cell-specific mAb-siRNA conjugates improve experimental myasthenia
This study sought to compare the efficacy of unique sets of monoclonal antibody-siRNA conjugates, individually (mono) or in combination (duo), against the crucial receptors predominantly or solely expressed on two subsets of B cells-plasma B cells and their precursor (transitional mature B) cells in a mouse model of MG. At the optimized doses, the conjugates, likely due to the combined activities of mAb and siRNA, substantially decreased the expression levels of CD268 (B cell-activating factor receptor) in mature B cells and CD269 (B-cell maturation antigen) in plasma cells concomitantly with reducing the levels of acetylc...
Source: Journal of Autoimmunity - January 14, 2023 Category: Allergy & Immunology Authors: Naazneen Ibtehaj Afrin Bahauddin Maxim Ivannikov Erik Rytting Mohammad Jamaluddin Yuejin Liang Jiaren Sun Sherry L Haller Xiaorong Wu Ruksana Huda Source Type: research
Nrf2 regulates the expression of NOX1 in TNF- α-induced A549 cells
In this study, we analyzed the potential regulatory role of nuclear factor erythroid-2-related factor 2 (Nrf2) on NADPH oxidase 1 (NOX1) in tumor necrosis factor-α (TNF-α)-induced inflammation and oxidative stress in human type II alveolar epithelial cells. In this study, A549 cells were transfected with Nrf2 siRNA and overexpression vectors for 6 h before being induced by TNF-α for 24 h. TNF-α upregulated the expression of NOX1 and Nrf2 in A549 cells. Furthermore, overexpression of Nrf2 could reduce TNF-α-induced NF-κB mRNA and protein expression after transfection with the Nrf2 siRNA vector, and the levels of IL-6,...
Source: Allergologia et Immunopathologia - January 9, 2023 Category: Allergy & Immunology Authors: Weijing Wu Jiamin Zhang Xiaoshan Su Xiaoping Lin Li Zhu Zesen Zhuang Chennan Liu Zhixing Zhu Yiming Zeng Source Type: research
Regulatory effect of IL-38 on NF- κB pathway in systemic lupus erythematosus
CONCLUSION: IL-38 may be involved in the occurrence and development of SLE by regulating the NF-κB signaling pathway. This study only discussed the relationship between IL-38 and NF-κB, and more biological functions of IL-38 need to be further studied.PMID:36621308 | DOI:10.1016/j.imbio.2022.152322
Source: Immunobiology - January 9, 2023 Category: Allergy & Immunology Authors: Jiyun Zhang Nurshati Tabush Chune Wei Li Luo Source Type: research
