Activation of estrogen receptor α inhibits TLR4 signaling in macrophages and alleviates the instability of atherosclerotic plaques in the postmenopausal stage

In conclusion, the present study demonstrates that decreased ERα expression promotes macrophage infiltration and plaque instability in the postmenopausal stage, and activation of ERα in the postmenopausal stage alleviates atherosclerotic plaque instability by inhibiting TLR4 signaling and macrophage-related inflammation.PMID:36764277 | DOI:10.1016/j.intimp.2023.109825

Source: International Immunopharmacology - February 10, 2023 Category: Allergy & Immunology Authors: Qinghai Meng Yunhui Bi Han Feng Xue Ding Shurui Zhang Qi Chen Liang Wang Qichun Zhang Yu Li Huangjin Tong Lixing Wu Huimin Bian Source Type: research