Epithelial CST1 Promotes Airway Eosinophilic Inflammation in Asthma via the AKT Signaling Pathway

CONCLUSIONS: Increased sputum CST1 may play a key role in the pathogenesis of asthma through involvement in eosinophilic and type 2 inflammation through activation of the AKT signaling pathway, further promoting SERPINB2 expression. Therefore, targeting CST1 might be of therapeutic value in treating asthma with severe and eosinophilic phenotypes.PMID:37075800

Source: Allergy, Asthma and Immunology Research - April 19, 2023 Category: Allergy & Immunology Authors: Lijuan Du Changyi Xu Kun Tang Jia Shi Lu Tang Xiao Lisha Chengcheng Lei Huicong Liu Yuxia Liang Yubiao Guo Source Type: research