TNF- α promotes CXCL-1/8 production in keratinocytes by downregulating galectin-3 through NF-κB and hsa-miR-27a-3p pathway to contribute psoriasis development

CONCLUSION: TNF-α initiates psoriatic inflammation by increasing CXCL-1/8 in keratinocytes mediated by the axis of NF-κB-hsa-miR-27a-3p-galectin-3 pathway.PMID:37358143 | DOI:10.1080/08923973.2023.2229510

Source: Immunopharmacology and Immunotoxicology - June 26, 2023 Category: Allergy & Immunology Authors: Xiao-Nan Qiu Dan Hong Zhen-Rui Shi Si-Yao Lu Yu-Xian Lai Yan-Ling Ren Xiu-Ting Liu Chi-Peng Guo Guo-Zhen Tan Liang-Chun Wang Source Type: research