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Specialty: Endocrinology

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Total 648 results found since Jan 2013.

Estrogen receptor beta signaling inhibits PDGF induced human airway smooth muscle proliferation
In this study, we evaluated the effect of selective ERα and ERβ modulators on platelet-derived growth factor (PDGF)-stimulated ASM proliferation and the mechanisms involved. Asthmatic and non-asthmatic primary human ASM cells were treated with PDGF, 17β-estradiol, ERα-agonist and/or ERβ-agonist and/or G-protein-coupled estrogen receptor 30 (GPR30/GPER) agonist and proliferation was measured using MTT and CyQuant assays followed by cell cycle analysis. Transfection of small interfering RNA (siRNA) ERα and ERβ significantly altered the human ASM proliferation. The specificity of siRNA transfection was confirmed by Wes...
Source: Molecular and Cellular Endocrinology - July 10, 2018 Category: Endocrinology Source Type: research

Activation of Estrogen Receptor Alpha Induces Beiging of Adipocytes
ConclusionOur results demonstrate for the first time that selective-activation of ERα in adipocytes increases markers of beiging and this is likely through induction of AMPK and ATGL-mediated lipolysis providing FFAs as a fuel to activate UCP-1.
Source: Molecular Metabolism - September 16, 2018 Category: Endocrinology Source Type: research

Growth hormone and Insulin-like growth factor-I (IGF-I) modulate the expression of L-type amino acid transporters in the muscles of spontaneous dwarf rats and L6 and C2C12 myocytes.
CONCLUSIONS: IGF-I increased LAT1 mRNA level in myocytes. However, the role of LAT1 in IGF-I-induced mTORC1 activation and cell functions remains unclear. PMID: 30273774 [PubMed - as supplied by publisher]
Source: Growth Hormone and IGF Research - September 23, 2018 Category: Endocrinology Authors: Sawa R, Nishida H, Yamamoto Y, Wake I, Kai N, Kikkawa U, Okimura Y Tags: Growth Horm IGF Res Source Type: research

Genome-wide profiling of histone H3K27 acetylation featured fatty acid signalling in pancreatic beta cells in diet-induced obesity in mice
Conclusions/interpretationThese results suggest novel roles for DNA-binding proteins and fatty acid signalling in obesity-induced epigenomic regulation of beta cell function.Data availabilityThe next-generation sequencing data in the present study were deposited at ArrayExpress.RNA-Seq:Dataset name: ERR2538129 (Control), ERR2538130 (Diet-induced obesity)Repository name and number: E-MTAB-6718 - RNA-Seq of pancreatic islets derived from mice fed a long-term high-fat diet against chow-fed controls.ChIP-Seq:Dataset name: ERR2538131 (Control), ERR2538132 (Diet-induced obesity)Repository name and number: E-MTAB-6719 - H3K27ac C...
Source: Diabetologia - November 5, 2018 Category: Endocrinology Source Type: research

Asprosin impairs insulin secretion in response to glucose and viability through TLR4/JNK-mediated inflammation
This report suggests asprosin as a novel therapeutic target for the treatment of type 2 diabetes through preservation of β-cell function.Graphical abstract
Source: Molecular and Cellular Endocrinology - March 8, 2019 Category: Endocrinology Source Type: research

Epigenetic Regulation of Diabetogenic Adipose Morphology
ConclusionCpG methylation could be influential in determining adipose morphology and thereby constitute a novel antidiabetic target. We identified C14orf180 as a novel regulator of adipocyte lipid storage and possibly differentiation.
Source: Molecular Metabolism - April 18, 2019 Category: Endocrinology Source Type: research

PLAC8 is overexpressed and regulates cell proliferation in low-grade human PanNET
Conclusion: Our findings establish PLAC8 as a central mediator of cell growth in a subset of human PanNET, providing evidence for the existence of distinct molecular subtypes within this class of tumors.
Source: Neuroendocrinology - April 25, 2019 Category: Endocrinology Source Type: research

Reduced cystathionine- γ-lyase (CSE) expression is involved in high glucose induced MMP14 expression in adipocytes and adipose tissues.
In conclusion, high glucose increased the expression of MMP14 in adipocytes and visceral adipose tissues through inhibiting the expression of CSE. PMID: 31366822 [PubMed - as supplied by publisher]
Source: Endocrine Journal - August 3, 2019 Category: Endocrinology Tags: Endocr J Source Type: research

The core clock gene, Bmal1, and its downstream target, the SNARE regulatory protein secretagogin, are necessary for circadian secretion of glucagon-like peptide-1
ConclusionsThese data demonstrate, for the first time, that mice display a circadian pattern in GLP-1 secretion, which is impaired in Bmal1 knockout mice, and that Bmal1 regulation of Scgn expression plays an essential role in the circadian release of the incretin hormone, GLP-1.
Source: Molecular Metabolism - November 21, 2019 Category: Endocrinology Source Type: research

Regulatory Effect of 1,25(OH)2D3 on TGF- β1 and miR-130b Expression in Streptozotocin-Induced Diabetic Nephropathy in Rats.
Conclusion: TGF-β1 can decrease the expression of miR-130b in kidney tissues of DN rats. Moreover, miR-130b may be involved in the protective effect of 1,25(OH)2D3 on renal fibrosis via TGF-β1. PMID: 31781203 [PubMed]
Source: International Journal of Endocrinology - December 1, 2019 Category: Endocrinology Tags: Int J Endocrinol Source Type: research

Thyroid Hormone Receptor: A New Player in Epinephrine-induced Larval Metamorphosis of the Hard-shelled Mussel.
Abstract Many marine invertebrate larvae undergo a dramatic morphological and physiological transition from a planktonic larva to a benthic juvenile. The mechanisms of this metamorphosis in bivalves are mainly unknown. The recent identification in bivalves of a thyroid hormone receptor (TR) gene raises the possibility that as occurs in vertebrate metamorphosis, TRs regulate this developmental process. An evolutionary study of TR receptors revealed they are ubiquitous in the molluscs. Knock-down of the TR gene in pediveliger larvae of the hard-shelled mussel, Mytilus coruscus (Mc), using electroporation of siRNA si...
Source: General and Comparative Endocrinology - November 29, 2019 Category: Endocrinology Authors: Li YF, Cheng YL, Chen K, Cheng ZY, Zhu X, C R Cardoso J, Liang X, Zhu YT, Power DM, Yang JL Tags: Gen Comp Endocrinol Source Type: research

Role of OCT4 in the Regulation of FSH-Induced Granulosa Cells Growth in Female Mice
As a member of the POU (Pit-Oct-Unc) transcription factor family, OCT4 (Octamer-binding transcription factor 4) is associated with the cellular proliferative. However, the roles of OCT4 in regulating the transition from preantral follicle to early antral follicle are still remains unclear. To evaluate the effect of OCT4 on cellular development in ovary, mice were injected with eCG in vivo or granulosa cells were co-cultured with FSH in vitro. The results showed that eCG up-regulated ovarian OCT4 expression. Meanwhile, OCT4 expression in granulosa cells was also up-regulated by FSH, and knockdown of OCT4 by siRNA significan...
Source: Frontiers in Endocrinology - January 9, 2020 Category: Endocrinology Source Type: research

Thioredoxin-interacting protein regulates glucose metabolism and improves the intracellular redox state in bovine oocytes during in vitro maturation.
Abstract The extent of glucose metabolism during oocyte maturation is closely related to oocyte developmental potential. Thioredoxin-interacting protein (TXNIP) is an α-arrestin family protein that negatively regulates glucose uptake into cells. However, little information is available regarding the function of TXNIP in bovine oocytes. Accordingly, the present study was performed to investigate the influence of TXNIP on glucose metabolism in bovine oocytes during in vitro maturation. Pharmacological inhibition of TXNIP by azaserine enhanced glucose uptake and imparted a specific metabolic effect on glycolysis and...
Source: Am J Physiol Endocri... - January 13, 2020 Category: Endocrinology Authors: Jiang X, Pang Y, Zhao S, Hao H, Zhao X, Du W, Wang Y, Zhu H Tags: Am J Physiol Endocrinol Metab Source Type: research

Common carp pentraxin gene: Evidence for its role in ovarian differentiation and growth.
Abstract Pentraxins (PTX), is an evolutionarily conserved family, containing a PTX protein domain, having a role in acute immunological responses and fertility in higher vertebrates. However, information regarding the action of ptx on reproduction is extremely limited in fish. To study this, ptx cDNA was cloned for downstream analysis. Tissue distribution and ontogeny expression analysis indicated the prevalence of ptx in ovary. Varied phase-wise expression during carp ovarian cycle and elevated ptx expression after human chorionic gonadotropin induction, in vitro and in vivo, indicated probable regulation of gona...
Source: General and Comparative Endocrinology - January 21, 2020 Category: Endocrinology Authors: Raj Gupta Y, Senthilkumaran B Tags: Gen Comp Endocrinol Source Type: research

Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells
ConclusionsWe demonstrate for the first time that RAI16 is a direct target gene of AR. RAI16 may involved in cell growth of prostate cancer cells in response to AR signaling.
Source: Molecular and Cellular Endocrinology - January 31, 2020 Category: Endocrinology Source Type: research