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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
Insulin receptor substrate 1 gene expression is strongly up-regulated by HSPB8 silencing in U87 glioma cells
Conclusions. Results of this investigation demonstrated that silencing of HSPB8 mRNA affected the expression of IRS1 gene as well as many other genes encoding tumor growth related proteins. It is possible that the dysregulation of most of the studied genes in glioma cells after silencing of HSPB8 is reflected by a complex of intergenic interactions and that this polyfunctional chaperone is an important factor for the stability of genome function and regulatory mechanisms contributing to the tumorigenesis control.PMID:33885248 | DOI:10.2478/enr-2020-0026
Source: Endocrine Regulations - April 22, 2021 Category: Endocrinology Authors: Oksana S Hnatiuk Dariia O Tsymbal Dmytro O Minchenko Olena O Khita Yulia M Viletska Olha V Rundytska Halyna E Kozynkevych Hanna S Maslak Oleksandr H Minchenko Source Type: research
PFKP Activation Ameliorates Foot Process Fusion in Podocytes in Diabetic Kidney Disease
ConclusionsThese findings provide evidence that PFKP may be a potential target for podocyte injury in DN and provide a rationale for applying podocyte glycolysis enhancing agents in patients with DKD.
Source: Frontiers in Endocrinology - January 14, 2022 Category: Endocrinology Source Type: research
Therapeutic Potential of Targeting Periostin in the Treatment of Graves ’ Orbitopathy
In this study we investigate periostin in the pathogenesis of Graves’ orbitopathy (GO) using human orbital adipose tissue obtained from surgery and primary cultured orbital fibroblasts in vitro. POSTN (gene encoding periostin) expression in Graves’ orbital tissues and healthy control tissues was studied, and the role of periostin in GO pathologic mechanism was examined through small-interfering RNA (siRNA)-mediated silencing. POSTN gene expression was significantly higher in Graves’ orbital tissues than healthy control tissues in real-time PCR results, and immunohistochemical staining revealed higher expression of pe...
Source: Frontiers in Endocrinology - May 30, 2022 Category: Endocrinology Source Type: research
IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes
CONCLUSIONS: The results of this study suggest that auto/paracrine IGF-1 contributes to Akt and ERK phosphorylation in chicken myotubes.PMID:35717687 | DOI:10.1016/j.ghir.2022.101478
Source: Growth Hormone and IGF Research - June 19, 2022 Category: Endocrinology Authors: Takaoki Saneyasu Tomonori Nakamura Kazuhisa Honda Hiroshi Kamisoyama Source Type: research
