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Specialty: Endocrinology

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Total 648 results found since Jan 2013.

IGF-1 knockdown inhibits phosphorylation of Akt and ERK in chicken embryonic myotubes
CONCLUSIONS: The results of this study suggest that auto/paracrine IGF-1 contributes to Akt and ERK phosphorylation in chicken myotubes.PMID:35717687 | DOI:10.1016/j.ghir.2022.101478
Source: Growth Hormone and IGF Research - June 19, 2022 Category: Endocrinology Authors: Takaoki Saneyasu Tomonori Nakamura Kazuhisa Honda Hiroshi Kamisoyama Source Type: research

Aberrant PI3K δ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers
ConclusionIn summary, our study has suggested a promising potential of utilizing PI3Kδ-S (an oncogenic isoform conferring drug resistance and exempt from PTEN regulation) as a prognostic biomarker and drug target in advanced endocrine cancers.
Source: Frontiers in Endocrinology - August 21, 2023 Category: Endocrinology Source Type: research

A novel mechanism by which SDF-1β protects cardiac cells from palmitate-induced ER stress and apoptosis via CXCR7 and AMPK/p38 MAPK-mediated IL-6 generation.
Abstract We studied the protective effect of stromal cell-derived factor-1beta (SDF-1β) on cardiac cells from lipotoxicity in vitro and diabetes in vivo. Exposure of cardiac cells to palmitate increased apoptosis by activating NADPH oxidase-associated nitrosative stress and endoplasmic reticulum (ER) stress, which abolished by pretreatment with SDF-1β via up-regulation of AMPK-mediated p38 MAPK phosphorylation and IL-6 production. The SDF-1β cardiac protection could be abolished by inhibition of AMPK, p38 MAPK or IL-6. Activation of AMPK or addition of recombinant IL-6 recaptured a similar cardiac protection. S...
Source: Diabetes - February 19, 2013 Category: Endocrinology Authors: Zhao Y, Tan Y, Xi S, Li Y, Li C, Cui J, Yan X, Li X, Wang G, Li W, Cai L Tags: Diabetes Source Type: research

Regulation of matrix metallopeptidase-9 by epigenetic modifications, and the development of diabetic retinopathy.
Abstract Diabetes activates retinal matrix metallopeptidase-9 (MMP-9), and MMP-9 damages the mitochondria and augments capillary cell apoptosis. Our aim is to elucidate the mechanism responsible for MMP-9 activation. Histone modifications and recruitment of the transcriptional factor NF-kB (p65 subunit) at MMP-9 promoter and the activity of lysine-specific demethylase 1 (LSD1) were measured in the retina from streptozotocin-induced diabetic rats. The role of LSD1 in MMP-9 activation was investigated in isolated retinal endothelial cells transfected with LSD1-siRNA. The results were confirmed in the retina from hum...
Source: Diabetes - February 19, 2013 Category: Endocrinology Authors: Zhong Q, Kowluru RA Tags: Diabetes Source Type: research

Downregulation of Fas activity rescues early onset of diabetes in c-KitWv/+ mice
c-Kit and its ligand stem cell factor (SCF) are important for β-cell survival and maturation; meanwhile, interactions between the Fas receptor (Fas) and Fas ligand are capable of triggering β-cell apoptosis. Disruption of c-Kit signaling leads to severe loss of β-cell mass and function with upregulation of Fas expression in c-KitWv/+ mouse islets, suggesting that there is a critical balance between c-Kit and Fas activation in β-cells. In the present study, we investigated the interrelationship between c-Kit and Fas activation that mediates β-cell survival and function. We generated double mutant, c...
Source: AJP: Endocrinology and Metabolism - March 15, 2013 Category: Endocrinology Authors: Feng, Z.-C., Riopel, M., Li, J., Donnelly, L., Wang, R. Tags: Articles Source Type: research

Ceramide 1-phosphate induces macrophage chemoattractant protein-1 release: involvement in ceramide 1-phosphate-stimulated cell migration
The bioactive sphingolipid ceramide 1-phosphate (C1P) is implicated in inflammatory responses and was recently shown to promote cell migration. However, the mechanisms involved in these actions are poorly described. Using J774A.1 macrophages, we have now discovered a new biological activity of C1P: stimulation of monocyte chemoattractant protein-1 (MCP-1) release. This novel effect of C1P was pertussis toxin (PTX) sensitive, suggesting the intervention of Gi protein-coupled receptors. Treatment of the macrophages with C1P caused activation of the phosphatidylinositol 3-kinase (PI3K)/Akt, mitogen-activated protein kinase ki...
Source: AJP: Endocrinology and Metabolism - June 1, 2013 Category: Endocrinology Authors: Arana, L., Ordonez, M., Ouro, A., Rivera, I.-G., Gangoiti, P., Trueba, M., Gomez-Munoz, A. Tags: Articles Source Type: research

Aberrant Overexpression of Pyruvate Kinase M2 Is Associated with Aggressive Tumor Features and the BRAF Mutation in Papillary Thyroid Cancer.
CONCLUSIONS:We conclude that overexpression of PKM2 provides a selective growth advantage for PTC cells through activation of glycolysis. Aberrant PKM2 overexpression may serve as a novel biomarker and a potential treatment target for PTC. The BRAF mutation may contribute to alterations in the expression pattern of glycolytic enzymes such as PKM2. PMID: 23846818 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - July 11, 2013 Category: Endocrinology Authors: Feng C, Gao Y, Wang C, Yu X, Zhang W, Guan H, Shan Z, Teng W Tags: J Clin Endocrinol Metab Source Type: research

Inhibition of Src Kinase Blocks High Glucose-Induced EGFR Transactivation and Collagen Synthesis in Mesangial Cells and Prevents Diabetic Nephropathy in Mice.
Abstract Chronic exposure to high glucose (HG) leads to diabetic nephropathy characterized by increased mesangial matrix protein, e.g. collagen, accumulation. Altered cell signaling and gene expression accompanied by oxidative stress has been documented. The contribution of the tyrosine kinase, c-Src (Src), which is sensitive to oxidative stress was examined.Cultured rat mesangial cells (MC) were exposed to HG (25 mM) in the presence and absence of Src inhibitors (PP2, SU6656), Src siRNA and the TNF-α converting enzyme (TACE) inhibitor, TAPI-2. Src was investigated in vivo by administration of PP2 to streptozotoc...
Source: Diabetes - August 13, 2013 Category: Endocrinology Authors: Taniguchi K, Xia L, Goldberg HJ, Lee KW, Shah A, Stavar L, A Y Masson E, Momen A, Shikatani EA, John R, Husain M, Fantus IG Tags: Diabetes Source Type: research

Compromise of Endogenous Neuropeptide W Production Abrogates the Dipsogenic and Pressor Effects of Angiotensin II in Adult, Male Rats
This article is protected by copyright. All rights reserved.
Source: Journal of Neuroendocrinology - September 12, 2013 Category: Endocrinology Authors: Alicia T. Pate, Gina L.C. Yosten, Willis K. Samson Tags: Original Article Source Type: research

Oncostatin M stimulates cell migration and proliferation by down-regulating E-cadherin in HTR8/SVneo cell line through STAT3 activation
Conclusions: This study suggests that OSM stimulates the migration and proliferation of EVTs during the first trimester of pregnancy through the down-regulation of E-cadherin. In addition, this study suggests that the effects of OSM on migration and proliferation are related to STAT3 activation, which is important in trophoblast invasiveness.
Source: Reproductive Biology and Endocrinology - September 24, 2013 Category: Endocrinology Authors: Hyun KoSae ChoiHee KangHo KimJi JeonIn ParkJong Shin Source Type: research

Leptin promotes the osteoblastic differentiation of vascular smooth muscle cells from female mice by increasing RANKL expression.
Abstract Arterial calcification is a complex and active regulated process, which results from a process of osteoblastic differentiation of vascular smooth muscle cells (VSMCs). Leptin, the product of the ob gene, mainly regulates food intake and energy expenditure and recently has been considered correlated with the arterial calcification. However, the mechanisms of the effects of leptin on osteoblastic differentiation of VSMCs are unknown. We used calcifying vascular smooth muscle cells (CVSMCs) as a model to investigate the relationship between leptin and the osteoblastic differentiation of CVSMCs and the signal...
Source: Endocrinology - November 18, 2013 Category: Endocrinology Authors: Liu GY, Liang QH, Cui RR, Liu Y, Wu SS, Shan PF, Yuan LQ, Liao EY Tags: Endocrinology Source Type: research

Sestrin 3 regulation in type 2 diabetic patients and its influence on metabolism and differentiation in skeletal muscle
In mammals, the sestrin family is composed of three stress-responsive genes. Ablation of sestrin in Drosophila attenuates longevity, which is accompanied by increased S6K phosphorylation and decreased AMPK phosphorylation. Nevertheless, the metabolic role of sestrins in mammals is not comprehensively understood. We characterized the expression of individual sestrin family members and determined their role in vastus lateralis muscle biopsies from participants with normal glucose tolerance (NGT) or type 2 diabetes (T2D). Expression of sestrin 1 or sestrin 2 mRNA was unaltered between the NGT and T2D participants. Conversely,...
Source: AJP: Endocrinology and Metabolism - December 1, 2013 Category: Endocrinology Authors: Nascimento, E. B., Osler, M. E., Zierath, J. R. Tags: Articles Source Type: research

Epithelial and stromal cells of bovine endometrium have roles in innate immunity and initiate inflammatory responses to bacterial lipopeptides in vitro via Toll-like receptors TLR2, TLR1 and TLR6.
Abstract Bacteria often infect the endometrium of cattle to cause endometritis, uterine disease and infertility. Lipopeptides are commonly found amongst bacteria and are detected by the Toll-like receptor (TLR) cell surface receptor TLR2 on immune cells. Heterodimers of TLR2 with TLR1 or TLR6 activate MAPK and NFκB intracellular signaling pathways to stimulate inflammatory responses. In the endometrium, epithelial and stromal cells are the first to encounter invading bacteria, so the present study explored whether endometrial cells can also mount inflammatory responses to bacterial lipopeptides via TLRs. The supe...
Source: Endocrinology - January 17, 2014 Category: Endocrinology Authors: Turner ML, Cronin JG, Healey GD, Sheldon IM Tags: Endocrinology Source Type: research