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Specialty: Endocrinology
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Total 648 results found since Jan 2013.
AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through the HSP72-mediated pathway in C2C12 skeletal muscle cells
5'-AMP-activated protein kinase (AMPK) plays an important role as a negative regulator of skeletal muscle mass. However, the precise mechanism of AMPK-mediated regulation of muscle mass is not fully clarified. Heat shock proteins (HSPs), stress-induced molecular chaperones, are related with skeletal muscle adaptation, but the association between AMPK and HSPs in skeletal muscle hypertrophy is unknown. Thus, we investigated whether AMPK regulates hypertrophy by mediating HSPs in C2C12 cells. The treatment with AICAR, a potent stimulator of AMPK, decreased 72-kDa HSP (HSP72) expression, whereas there were no changes in the e...
Source: AJP: Endocrinology and Metabolism - February 1, 2014 Category: Endocrinology Authors: Egawa, T., Ohno, Y., Goto, A., Ikuta, A., Suzuki, M., Ohira, T., Yokoyama, S., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K. Tags: Articles Source Type: research
Induction of PGF2α synthesis by cortisol through GR dependent induction of CBR1 in human amnion fibroblasts.
In conclusion, CBR1 may play a critical role in PGF2α synthesis in human amnion fibroblasts and cortisol promotes the conversion of PGE2 into PGF2α via GR-mediated induction of CBR1 in human amnion fibroblasts. This stimulatory effect of cortisol on CBR1 expression may explain at least in part the concurrent increases of cortisol and PGF2α in human amnion tissue with labor, and these findings may account for the increased production of PGF2α in the fetal membranes prior to the onset of labor.
PMID: 24654784 [PubMed - as supplied by publisher]
Source: Endocrinology - March 21, 2014 Category: Endocrinology Authors: Guo C, Wang W, Liu C, Myatt L, Sun K Tags: Endocrinology Source Type: research
Aldosterone's rapid, nongenomic effects are mediated by striatin: a modulator of aldosterone's effect on estrogen action.
In conclusion, our results indicate that striatin is a novel mediator for both aldosterone's and estrogen's rapid and nongenomic mechanisms of action on pERK and peNOS, respectively, thereby suggesting a unique level of interactions between the mineralocorticoid receptor and the estrogen receptor in the cardiovascular system.
PMID: 24654783 [PubMed - as supplied by publisher]
Source: Endocrinology - March 21, 2014 Category: Endocrinology Authors: Coutinho P, Vega C, Pojoga LH, Rivera A, Prado GN, Yao TM, Adler G, Torres-Grajales M, Maldonado ER, Ramos-Rivera A, Williams J, Williams G, Romero JR Tags: Endocrinology Source Type: research
Advanced Glycation End Product 3 (AGE3) Suppresses the Mineralization of Mouse Stromal ST2 Cells and Human Mesenchymal Stem Cells by Increasing TGF-β Expression and Secretion.
Abstract
In diabetic patients, advanced glycation end products (AGEs) cause bone fragility because of deterioration of bone quality. We previously showed that AGEs suppressed the mineralization of mouse stromal ST2 cells. Transforming growth factor (TGF)-β is abundant in bone, and enhancement of its signal causes bone quality deterioration. However, whether TGF-β signaling is involved in the AGE-induced suppression of mineralization during the osteoblast lineage remains unknown. We therefore examined the roles of TGF-β in the AGE-induced suppression of mineralization of ST2 cells and human mesenchymal stem cell...
Source: Endocrinology - April 23, 2014 Category: Endocrinology Authors: Notsu M, Yamaguchi T, Okazaki K, Tanaka KI, Ogawa N, Kanazawa I, Sugimoto T Tags: Endocrinology Source Type: research
Activin A, B and AB increase human trophoblast cell invasion by up-regulating N-cadherin.
Conclusion: Activin A, B and AB produce comparable increases in human trophoblast cell invasion by up-regulating N-cadherin expression in a SMAD2/3-SMAD4-dependent manner.
PMID: 25105734 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 8, 2014 Category: Endocrinology Authors: Li Y, Klausen C, Cheng JC, Zhu H, Leung PC Tags: J Clin Endocrinol Metab Source Type: research
Characterization of GAB1 expression over the menstrual cycle in women with and without Polycystic Ovarian Syndrome provides a new insight into its pathophysiology.
Conclusions: GAB1 mRNA expression is positively modulated by E2. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation.
PMID: 25144631 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - August 21, 2014 Category: Endocrinology Authors: Roemer KL, Young SL, Savaris RF Tags: J Clin Endocrinol Metab Source Type: research
Selective inhibition of sphingosine kinase-1 protects adipose tissue against LPS-induced inflammatory response in Zucker diabetic fatty rats
The objective of the present study was to evaluate whether the enzyme sphingosine kinase-1 (SK1) would modulate the expression of CCL5 and other inflammatory biomarkers in primary adipocytes and its potential role in lipopolysaccharide (LPS)-induced AT inflammation in a rat model of diabetes. To address this, LPS-stimulated primary adipocytes and 3T3-L1 cells were treated with a SK inhibitor, and the expression of Ccl5 and other CC chemokines were studied. Moreover, the effect of SK1 knockdown on cytokine production was analyzed in 3T3-L1 cells by transfection of SK1-specific small-interfering RNA (siRNA). The anti-inflamm...
Source: AJP: Endocrinology and Metabolism - September 1, 2014 Category: Endocrinology Authors: Tous, M., Ferrer-Lorente, R., Badimon, L. Tags: Articles Source Type: research
High-calorie diet exacerbates prostate neoplasia in mice with haploinsufficiency of Pten tumor suppressor gene
Conclusion High-calorie diet promotes prostate cancer progression in the genetically susceptible Pten haploinsufficient mouse while preserving insulin sensitivity. This appears to be partly due to increased inflammatory response to high-caloric intake in addition to increased ability of insulin to promote lipogenesis. Graphical abstract
Source: Molecular Metabolism - January 3, 2015 Category: Endocrinology Source Type: research
Pulsed electromagnetic fields promote osteoblast mineralization and maturation needing the existence of primary cilia
Publication date: 15 March 2015 Source:Molecular and Cellular Endocrinology, Volume 404 Author(s): Juan-Li Yan , Jian Zhou , Hui-Ping Ma , Xiao-Ni Ma , Yu-Hai Gao , Wen-Gui Shi , Qing-Qing Fang , Qian Ren , Cory J. Xian , Ke-Ming Chen Although pulsed electromagnetic fields (PEMFs) have been approved as a therapy for osteoporosis, action mechanisms and optimal parameters are elusive. To determine the optimal intensity, exposure effects of 50 Hz PEMFs of 0.6–3.6 mT (0.6 interval at 90 min/day) were investigated on proliferation and osteogenic differentiation of cultured calvarial osteoblasts. All intensity groups sti...
Source: Molecular and Cellular Endocrinology - March 10, 2015 Category: Endocrinology Source Type: research
Calcitriol prevents in vitro vascular smooth muscle cell mineralization by regulating Calcium-Sensing Receptor expression.
In conclusion, these findings suggest that nanomolar concentrations of 1,25(OH)2D3 induce a CaSR-dependent protection against VC. Both lower and higher concentrations are either ineffective or may even promote VC. Whether this also holds true in the clinical setting requires further study.
PMID: 25763635 [PubMed - as supplied by publisher]
Source: Endocrinology - March 12, 2015 Category: Endocrinology Authors: Mary A, Hénaut L, Boudot C, Six I, Brazier M, Massy ZA, Drüeke TB, Kamel S, Mentaverri R Tags: Endocrinology Source Type: research
Dihydromyricetin improves skeletal muscle insulin resistance by inducing autophagy via the AMPK signaling pathway
In conclusion, DHM improved SMIR by inducing autophagy via the activation of AMPK signaling pathway.
Source: Molecular and Cellular Endocrinology - March 20, 2015 Category: Endocrinology Source Type: research
Masculinisation of the Zebra Finch Song System: Roles of Oestradiol and the Z‐chromosome Gene Tubulin‐Specific Chaperone Protein A
Robust sex differences in brain and behaviour exist in zebra finches. Only males sing, and forebrain song control regions are more developed in males. The factors driving these differences are not clear, although numerous experiments have shown that oestradiol (E2) administered to female hatchlings partially masculinises brain and behaviour. Recent studies suggest that an increased expression of Z‐chromosome genes in males (ZZ; females: ZW) might also play a role. The Z‐gene tubulin‐specific chaperone A (TBCA) exhibits increased expression in the lateral magnocellular nucleus of the anterior nidopallium (LMAN) of juv...
Source: Journal of Neuroendocrinology - April 16, 2015 Category: Endocrinology Authors: L. Q. Beach, J. Wade Tags: Original Article Source Type: research
Removal of Rev-erb{alpha} inhibition contributes to the prostaglandin G/H synthase 2 expression in rat endometrial stromal cells
This study focused on Ptgs2, which is essential for decidualization, as a putative clock-controlled gene, and aimed to reveal the functions of clock genes in relation to Ptgs2 during decidualization. We compared the transcript levels of clock genes in the rat uterus on days 4.5 (D4.5) and 6.5 of pregnancy. The transcript levels of clock genes (Per2, Bmal1, Rorα, and Rev-erbα) had decreased at implantation sites on day 6.5 (D6.5e) compared with those on D4.5, whereas Ptgs2 transcripts had increased on D6.5e. Similar observations of Rev-erbα and Ptgs2 were also obtained in the endometrium on D6.5e by immuno...
Source: AJP: Endocrinology and Metabolism - April 15, 2015 Category: Endocrinology Authors: Isayama, K., Zhao, L., Chen, H., Yamauchi, N., Shigeyoshi, Y., Hashimoto, S., Hattori, M.-a. Tags: Articles Source Type: research
Brain-derived neurotrophic factor regulates cell motility in human colon cancer
Brain-derived neurotrophic factor (BDNF) is a potent neurotrophic factor that has been shown to affect cancer cell metastasis and migration. In the present study, we investigated the mechanisms of BDNF-induced cell migration in colon cancer cells. The migratory activities of two colon cancer cell lines, HCT116 and SW480, were found to be increased in the presence of human BDNF. Heme oxygenase-1 (HO)-1 is known to be involved in the development and progression of tumors. However, the molecular mechanisms that underlie HO-1 in the regulation of colon cancer cell migration remain unclear. Expression of HO-1 protein and mRNA i...
Source: Endocrine-Related Cancer - June 1, 2015 Category: Endocrinology Authors: Huang, S.-M., Lin, C., Lin, H.-Y., Chiu, C.-M., Fang, C.-W., Liao, K.-F., Chen, D.-R., Yeh, W.-L. Tags: Research Source Type: research
Dot1L mediated histone H3 lysine79 methylation is essential to meiosis progression in mouse oocytes.
CONCLUSION: Dot1L protein is well distributed in mouse GV stage oocytes. Dot1L and H3K79 methylation play important roles in meiosis progression and are supposed to be associated with chromosome deacetylation of mouse oocytes.
PMID: 25433842 [PubMed - indexed for MEDLINE]
Source: Neuroendocrinology Letters - June 4, 2015 Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research
