Characterization of GAB1 expression over the menstrual cycle in women with and without Polycystic Ovarian Syndrome provides a new insight into its pathophysiology.
Conclusions: GAB1 mRNA expression is positively modulated by E2. Endometrial GAB1 protein and mRNA expression are reduced in women with PCOS, suggesting that the endometrium of PCOS women have a defect in insulin signaling due to GAB1 down-regulation.
PMID: 25144631 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Roemer KL, Young SL, Savaris RF Tags: J Clin Endocrinol Metab Source Type: research
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