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Total 1410 results found since Jan 2013.

TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLC γ.
TSPAN1 upregulates MMP2 to promote pancreatic cancer cell migration and invasion via PLCγ. Oncol Rep. 2019 Jan 30;: Authors: Zhang X, Shi G, Gao F, Liu P, Wang H, Tan X Abstract Pancreatic cancer (PC), a malignancy of the digestive system, has one of the highest rates of metastasis and mortality. It is characterized by the detachment, migration, implantation and infiltration of tumor cells to form metastases or recurrent foci. Tetraspanin 1 (TSPAN1), a novel member of the TSPAN superfamily, is highly expressed in many types of cancer, including gastric, colon, liver and esophageal cancer. It has also ...
Source: Oncology Reports - February 7, 2019 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Mucin 1 downregulation impairs the anti-necroptotic effects of glucocorticoids in human bronchial epithelial cells
Publication date: Available online 7 February 2019Source: Life SciencesAuthor(s): Huojun Zhang, Qian Liu, Luxia Kong, Shuyun XuAbstractAimsTo investigate whether mucin 1 (MUC1) downregulation reduced the sensitivity of tumor necrosis factor-alpha (TNF-α)-induced bronchial epithelial cells to glucocorticoid-mediated necroptosis and explore the underlying mechanisms.Main methodsThe human lung bronchial epithelial cell line (16HBE) was transfected with small interfering RNA (siRNA) against MUC1 and then stimulated by TNF-α, where some cells were pretreated with dexamethasone. Flow cytometry was performed to analyze necropto...
Source: Life Sciences - February 7, 2019 Category: Biology Source Type: research

Cellular mechanism of T β4 intervention in liver fibrosis by regulating NF-κB signaling pathway.
CONCLUSIONS: Tβ4 significantly inhibited IL-1β-induced HSC-LX2 cell proliferation. The mechanism may involve decreased activation of the NF-κB pathway, decreased expression of p-IKB and nuclear translocation of p65. Therefore, Tβ4 had the effect of reversing liver fibrosis. PMID: 30779097 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - February 21, 2019 Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research

PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression
Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments...
Source: Frontiers in Oncology - April 16, 2019 Category: Cancer & Oncology Source Type: research

NOD2 and TLR2 Signal via TBK1 and PI31 to Direct Cross-Presentation and CD8 T Cell Responses
The objective of this study was to explore the role of NOD2 and TLR2 in cross-presentation in human dendritic cells undertaking an unbiased screen. We have used a quantitative phosphoproteomic analysis by liquid chromatography-tandem mass spectrometry (LC-MS/MS) followed by a computational analysis to identify the proteins as differentially abundant in response to NOD2 and TLR2 sensing. Validation of the phosphoproteomic analysis was performed by the detection of proteins in phosphoenriched lysates and detected by western blot. Techniques for the modulation of gene expression (shRNA and siRNA) were used to confirm the resu...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

LncPVT1 promotes cartilage degradation in diabetic OA mice by downregulating miR-146a and activating TGF- β/SMAD4 signaling
ConclusionsOur results demonstrate LncRNA PVT1 is involved in cartilage degradation in diabetic OA and correlated with disease severity. Efficiency of ad-siRNA-PVT1 in controlling joint inflammation in diabetic OA mice is associated with the suppression of the expression of miR-146a, pro-inflammatory cytokines and activation of TGF- β/SMAD4 pathway.
Source: Journal of Bone and Mineral Metabolism - February 10, 2021 Category: Orthopaedics Source Type: research

ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response
CONCLUSIONS: ATF5 could exert a protective effect in a very early stage but promoted tubulointerstitial injury by regulating HSP60 and the UPRmt pathway under DKD conditions, providing a potential target for the prevention of DKD progression.PMID:37095454 | DOI:10.1186/s10020-023-00651-4
Source: Molecular Medicine - April 24, 2023 Category: Molecular Biology Authors: Yifei Liu Lei Zhang Shumin Zhang Jialu Liu Xiaohui Li Kexin Yang Danyi Yang Yu Liu Lin Sun Fuyou Liu Li Xiao Source Type: research

HMGB1 induces an inflammatory response in endothelial cells via the RAGE-dependent endoplasmic reticulum stress pathway.
Abstract The high mobility group 1B protein (HMGB1) mediates chronic inflammatory responses in endothelial cells, which play a critical role in atherosclerosis. However, the underlying mechanism is unknown. The goal of our study was to identify the effects of HMGB1 on the RAGE-induced inflammatory response in endothelial cells and test the possible involvement of the endoplasmic reticulum stress pathway. Our results showed that incubation of endothelial cells with HMGB1 (0.01-1μg/ml) for 24h induced a dose-dependent activation of endoplasmic reticulum stress transducers, as assessed by PERK and IRE1 protein expre...
Source: Biochemical and Biophysical Research communications - July 31, 2013 Category: Biochemistry Authors: Luo Y, Li SJ, Yang J, Qiu YZ, Chen FP Tags: Biochem Biophys Res Commun Source Type: research

Transcriptional and Epigenetic Modulation of Human Rhinovirus-Induced CXCL10 Production by Cigarette Smoke.
Abstract Human rhinovirus (HRV) triggers exacerbations of asthma and chronic obstructive pulmonary disease (COPD). Cigarette smoking is the primary risk factor for the development of COPD and 25% of asthmatics smoke. Smokers experience both longer and more severe colds. We previously showed that cigarette smoke extract (CSE) inhibited HRV-induced expression of a range of epithelial antiviral molecules. Here, we use CXCL10 as a model antiviral gene to examine the mechanisms by which CSE inhibits epithelial antiviral immunity. HRV-induced CXCL10 transcription depends upon activation of nuclear factor-ĸB (NF-ĸB) an...
Source: American Journal of Respiratory Cell and Molecular Biology - October 15, 2013 Category: Molecular Biology Authors: Hudy MH, Traves SL, Proud D Tags: Am J Respir Cell Mol Biol Source Type: research

Interleukin‐17A Stimulates Migration of Periodontal Ligament Fibroblasts Via p38 MAPK/NF‐κB ‐Dependent MMP‐1 Expression
In this study, we report that IL‐17A can increase the migration and expression of matrix metalloproteinase (MMP)‐1 in human periodontal ligament (PDL) fibroblasts but has no effect on PDL fibroblast proliferation. IL‐17A‐induced MMP‐1 expression led to cell migration, which was attenuated by pre‐treatment with IL‐17 receptor neutralizing antibody and small interfering RNA (siRNA) for MMP‐1. The IL‐17A‐induced cell migration was also attenuated by its tissue inhibitor of matrix metalloproteinase (TIMP)‐1. In addition, a p38 mitogen‐activated protein kinase (MAPK) inhibitor (SB203580) inhibited IL‐1...
Source: Journal of Cellular Physiology - November 22, 2013 Category: Cytology Authors: Yan Wu, Lingxin Zhu, Lingshuang Liu, Jie Zhang, Bin Peng Tags: Original Research Article Source Type: research

Nox2/ROS-dependent human antigen R translocation contributes to TNF-α-induced SOCS-3 expression in human tracheal smooth muscle cells.
Abstract Elevated levels of TNF-α have been detected in the airway fluids, which may induce up-regulation of inflammatory proteins. Suppressors of cytokine signaling (SOCS)-3 proteins can be induced by various cytokines and negatively regulated inflammatory responses. Although TNF-α has been shown to induce SOCS-3 expression, the mechanisms underlying TNF-α-induced SOCS-3 expression in human tracheal smooth muscle cells (HTSMCs) remain unclear. Here, we showed that TNF-α induced SOCS-3 expression in HTSMCs and in the airways of mice, which was inhibited by pretreatment with the inhibitor of transcription level...
Source: Am J Physiol Lung Ce... - January 10, 2014 Category: Respiratory Medicine Authors: Hsu CK, Lee IT, Lin CC, Hsiao LD, Yang CM Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research

Role of Annexin A5 in Cisplatin-induced Toxicity Cell Biology
In this study, we aimed to verify the function of annexin A5 in the apoptosis of renal epithelial cells. Real-time PCR and Western blot analysis, together with immunofluorescence analysis, showed that the expression of annexin A5 significantly increased in the presence of cisplatin in both human and rat renal epithelial cells. With regard to the mechanism of cisplatin-induced apoptosis, apoptosis-inducing factor (AIF) release into the cytosol was observed, and the underlying mechanism was identified as voltage-dependent anion channel (VDAC) oligomerization. Mitochondrial membrane potential (Δψm) was found to be greatly d...
Source: Journal of Biological Chemistry - January 24, 2014 Category: Chemistry Authors: Jeong, J.-J., Park, N., Kwon, Y.-J., Ye, D.-J., Moon, A., Chun, Y.-J. Tags: Molecular Bases of Disease Source Type: research

Nox2/ROS-dependent human antigen R translocation contributes to TNF-{alpha}-induced SOCS-3 expression in human tracheal smooth muscle cells
Elevated levels of TNF-α have been detected in the airway fluids, which may induce upregulation of inflammatory proteins. Suppressors of cytokine signaling (SOCS)-3 proteins can be induced by various cytokines and negatively regulated inflammatory responses. Although TNF-α has been shown to induce SOCS-3 expression, the mechanisms underlying TNF-α-induced SOCS-3 expression in human tracheal smooth muscle cells (HTSMCs) remain unclear. Here, we showed that TNF-α induced SOCS-3 expression, which was inhibited by pretreatment with the inhibitor of transcription level (actinomycin D), translation level ...
Source: AJP: Lung Cellular and Molecular Physiology - March 15, 2014 Category: Respiratory Medicine Authors: Hsu, C.-K., Lee, I.-T., Lin, C.-C., Hsiao, L.-D., Yang, C.-M. Tags: ARTICLES Source Type: research

Curcumin protects neurons against oxygen‐glucose deprivation/reoxygenation‐induced injury through activation of peroxisome proliferator‐activated receptor‐γ function
This study tested whether the neuroprotective effects of curcumin against oxygen–glucose deprivation/reoxygenation (OGD/R)‐induced injury of rat cortical neurons are mediated (at least in part) by PPARγ. Curcumin (10 μM) potently enhanced PPARγ expression and transcriptional activity following OGD/R. In addition, curcumin markedly increased neuronal viability, as evidenced by decreased lactate dehydrogenase release and reduced nitric oxide production, caspase‐3 activity, and apoptosis. These protective effects were suppressed by coadministration of the PPARγ antagonist 2‐chloro‐5‐nitrobenzanilide (GW9662) a...
Source: Journal of Neuroscience Research - June 26, 2014 Category: Neuroscience Authors: Zun‐Jing Liu, Hong‐Qiang Liu, Cheng Xiao, Hui‐Zhen Fan, Qing Huang, Yun‐Hai Liu, Yu Wang Tags: Research Article Source Type: research

Contribution of protein kinase Cα in the stimulation of insulin by the down-regulation of Ca v β subunits
We examined whether other types of Cavβ subunits also have similar properties. In this regard, we used small interfering RNA (siRNA) of these subunits (20 μg each) to down-regulate them and examined blood glucose, serum insulin and PKC translocation in isolated pancreatic β cells of mice. While the down-regulation of Cavβ2 and β3 subunits increased serum insulin levels and caused efficient glucose homeostasis, the down-regulation of Cavβ1 and β4 subunits failed to affect both these parameters. Examination of PKC isozymes in the pancreatic β-cells of Cavβ2- or β3 siRNA-injected mice showed that three PKC isozymes...
Source: Endocrine - October 23, 2014 Category: Endocrinology Source Type: research