PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression

Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments, the exact detailed mechanism of breast cancer development is still largely unknown (3). The peroxisome proliferator-activated receptor-γ (PPARγ) co-activator-1β (PGC1β) is involved with tumor growth and metastasis, promoting tumorigenesis by modulation of mitochondrial function and glycolysis metabolism (4–8). PGC1β knockdown impairs ERRα signaling and reduces cell proliferation, suggesting a potential role of PGC1β in the pathogenesis of breast cancers (6). Sterol regulatory element-binding proteins (SREBPs) regulate many genes involved in lipid metabolism (9), and this process requires the expression of PGC1β (10). Three isoforms of SREBPs, including SREBP-1a,−1c, and−2, have been described, where SREBP-1a and SREBP-1c are encoded by a single gene with alternative sp...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research