PGC1 β Regulates Breast Tumor Growth and Metastasis by SREBP1-Mediated HKDC1 Expression

Conclusions: PGC1β regulates breast cancer tumor growth and metastasis by SREBP1-mediated HKDC1 expression. This provides a novel therapeutic strategy through targeting the PGC1β/HKDC1 signaling pathway for breast cancer treatment. Introduction Breast cancer is a very common cancer with significant premature mortality in women. Around 12% of women in USA will have chance to be diagnosed with breast cancer during their lifetimes (1, 2). The development of breast cancer is regulated by many factors, and even as average survival rates have increased significantly as a result of many advanced treatments, the exact detailed mechanism of breast cancer development is still largely unknown (3). The peroxisome proliferator-activated receptor-γ (PPARγ) co-activator-1β (PGC1β) is involved with tumor growth and metastasis, promoting tumorigenesis by modulation of mitochondrial function and glycolysis metabolism (4–8). PGC1β knockdown impairs ERRα signaling and reduces cell proliferation, suggesting a potential role of PGC1β in the pathogenesis of breast cancers (6). Sterol regulatory element-binding proteins (SREBPs) regulate many genes involved in lipid metabolism (9), and this process requires the expression of PGC1β (10). Three isoforms of SREBPs, including SREBP-1a,−1c, and−2, have been described, where SREBP-1a and SREBP-1c are encoded by a single gene with alternative splicing and promoters (11), while ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research

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Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Surendra Gulla, Dakshayani Lomada, Vadali V.S.S. Srikanth, Muthukonda Venkatakrishnan Shankar, Kakarla Raghava Reddy, Sarvesh Soni, Madhava C. ReddyAbstractNanoparticles' based cancer therapeutics are greatly dependent on the development of science and engineering of nanoparticles. In this article, important strategies based on nanoparticles used for cancer treatment are discussed. The inspiration to write this article is not only to review the existing strategies based on nanoparticles but also to highlight the pertinent and possible solutions ther...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Kakarla Raghava Reddy, Pattubala Adinaraya Reddy, Chandragiri Venkata Reddy, Nagaraj P. Shetti, Bhatula Babu, Koutavarapu Ravindranadh, Muthukonda Venkatakrishnan Shankar, Madhava C. Reddy, Sarvesh Soni, Shivalingegowda NaveenAbstractSuperparamagnetic iron oxide nanoparticles (SPIONs) are the most extensively used functional nanomaterials as antibacterial agents, and for other biomedical applications due to their unique physical, chemical, magnetic and biocompatibility properties. However, due to their small size, particles tend to aggregate by dipo...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Pankaj Satapathy, Kounaina Khan, Aishwarya Tripurasundari Devi, Anirudh Gururaj Patil, Avinash Mirle Govindaraju, Shubha Gopal, Mysore Nagalingaswamy Nagendra Prasad, Veena Sunil More, Raghava Reddy Kakarla, Anjanapura V. Raghu, Shivaprasad Hudeda, Sunil Shivaji More, Farhan ZameerAbstractMicrobes exist in every type of environment and the human gut is no exception. These microbes play a very crucial role in health and metabolism. Synthetic Gutomics is an effort to describe the engineering of the gut microbiota for ameliorating human disorders. This...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Hemraj ChhipaAbstractExcess use of chemical fertilizers and pesticides has shown negative impacts on soil health and environment. Chemical residues destroy the soil ecosystem by affecting the non-targeted organisms and decrease soil fertility simultaneously. To prevent such adversity in soil and environment, researchers have applied nanotechnology in agriculture. Nanotechnology is the rising technology of the current decade, which has shown promising results in controlling excess agri-inputs and maintaining environmental balance. The characteristics...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
Publication date: 2019Source: Methods in Microbiology, Volume 46Author(s): Aaron Elbourne, Vi Khanh Truong, Samuel Cheeseman, Piumie Rajapaksha, Sheeana Gangadoo, James Chapman, Russell J. CrawfordAbstractAntimicrobial resistance (AMR) has been identified as one of the greatest threats to human health (Boucher et al., 2009, Bush et al., 2011, Centers for Disease Control and Prevention, 2013, Neu, 1992, Spellberg et al., 2008). Unfortunately, the current rise in AMR has made biofilm-related infections a primary health-care concern, since these biofilms can no longer be effectively treated using conventional antibiotic metho...
Source: Methods in Microbiology - Category: Microbiology Source Type: research
In this work, the four optimum azimuthal angles are determined for a full-Stokes scanning polarimeter comprising a rectangular prism, quarter-wave plate, and four linear polarizers. The determinant and condition numbers of the measurement matrix are used as objective functions in an optimization ...
Source: Applied Optics - Category: Physics Authors: Source Type: research
Publication date: Available online 21 May 2019Source: Biocatalysis and Agricultural BiotechnologyAuthor(s): Lamia Abou El-Kassem, Usama W. Hawas, Sahar El-Souda, Eman F. Ahmed, Wail El-Khateeb, Walid FayadAbstractForty-eight endophytic fungal strains were isolated and purified from ten Egyptian medicinal plants and their culture broth extracts were explored for HCV protease inhibitory activity and cytotoxicity. The ethyl acetate extracts of Alternaria alternata PGL-3, Cochlibolus lunatus PML-17, Nigrospora sphaerica EPS-38, followed by Emerecilla nidulans RPL-21 showed the most potent inhibition of HCV NS3/4A protease with...
Source: Biocatalysis and Agricultural Biotechnology - Category: Biotechnology Source Type: research
PMID: 31109503 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109502 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
PMID: 31109500 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
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