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Condition: Diabetes
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Total 1499 results found since Jan 2013.
Advanced glycation end products induce the apoptosis of and inflammation in mouse podocytes through CXCL9-mediated JAK2/STAT3 pathway activation.
In this study, we found that the serum and urine levels of C-X-C motif chemokine ligand 9 (CXCL9) were significantly elevated in patients with DN compared with healthy controls. Based on an in vitro model of mouse podocyte injury, AGEs decreased the proliferation of podocytes and increased the expression of CXCL9 and C-X-C motif chemokine receptor 3 (CXCR3), and promoted the activation of signal transducer and activator of transcription 3 (STAT3). The knockdown of CXCL9 by the transfection of mouse podoyctes with specific siRNA significantly increased the proliferation and decreased the apoptosis of the podoyctes. ...
Source: International Journal of Molecular Medicine - August 11, 2017 Category: Molecular Biology Authors: Yu J, Wu H, Liu ZY, Zhu Q, Shan C, Zhang KQ Tags: Int J Mol Med Source Type: research
LncRNA NONRATT021972 Was Associated with Neuropathic Pain Scoring in Patients with Type 2 Diabetes.
CONCLUSION: LncRNA NONRATT021972 increased in type 2 diabetes and was positively associated with neuropathic pain scoring in type 2 diabetes. LncRNA NONRATT021972 exacerbated neuropathic pain via TNF-α related pathways.
PMID: 28928602 [PubMed - in process]
Source: Behavioural Neurology - September 22, 2017 Category: Neurology Authors: Yu W, Zhao GQ, Cao RJ, Zhu ZH, Li K Tags: Behav Neurol Source Type: research
Contribution of myo-inositol oxygenase in age: rage mediated renal tubulo-interstitial injury in the context of diabetic nephropathy.
CONTRIBUTION OF MYO-INOSITOL OXYGENASE IN AGE: RAGE MEDIATED RENAL TUBULO-INTERSTITIAL INJURY IN THE CONTEXT OF DIABETIC NEPHROPATHY.
Am J Physiol Renal Physiol. 2017 Sep 20;:ajprenal.00434.2017
Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS
Abstract
Advanced glycation end products (AGEs) play a role in pathogenesis of diabetic nephropathy (DN). Myo-inositol Oxygenase (MIOX) has been implicated in tubulo-interstitial injury in the context of DN. We investigated the effect of AGEs on MIOX expression and delineated mechanisms that lead to tubulo-interstitial injury. Status of MIOX, RAGE and relevant ...
Source: Am J Physiol Renal P... - September 20, 2017 Category: Urology & Nephrology Authors: Sharma I, Tupe RS, Wallner AK, Kanwar YS Tags: Am J Physiol Renal Physiol Source Type: research
Small Interfering RNA Inhibition of Cannabanoid-1 Receptor (CB1R) for Treating Type 2 Diabetes
The invention pertains to the use of glucan encapsulated non-immunostimulatory small interfering RNAs (siRNAs) to treat type-2 diabetes. Endocannabinoids (EC) are lipid signaling molecules that act on the same cannabinoid receptors that recognize and mediate the effects of endo- and phytocannabanoids. EC receptor CB1R activation is implicated in the development of obesity and its metabolic consequences, including insulin resistance and type 2 diabetes. Beta-cell loss has been demonstrated in a Zucker diabetic fatty (ZDF) rat model of type-2 diabetes through CB1R-mediated activation of a macrophage-mediated inflammatory res...
Source: NIH OTT Licensing Opportunities - September 19, 2013 Category: Research Authors: ajoyprabhu3 Source Type: research
14 The mechanism of pkcB-p66shc-nadph oxidase pathway in high glucose induced-oxidative stress in renal tubular epithelial cells
Conclusion
The study clarified a novel mechanism of oxidative stress damaging HK-2 cells via the modulation of the PKCβ-P66Shc-NADPH oxidase pathway. Understanding the molecular pathway of oxidative stress could translate into the development of therapeutic strategies for diabetic nephropathy.
Acknowledgements
This work was supported by the National Natural Science Foundation of China [No. 81400300] and Natural Science Foundation of Jiangsu Province [No. BK20130642].
Source: Journal of Investigative Medicine - November 24, 2017 Category: Research Authors: Cheng, Y., Chao, J., Zhu, D., Liu, B. Tags: Abstracts Source Type: research
HSPB8 Promotes the Fusion of Autophagosome and Lysosome during Autophagy in Diabetic Neurons.
Authors: Li XC, Hu QK, Chen L, Liu SY, Su S, Tao H, Zhang LN, Sun T, He LJ
Abstract
Although autophagy has been proposed to play an emerging role in diabetic neuropathy, autophagy and its possible role remains unclear. Moreover, only few studies about diabetes have explored the autophagy mediated by heat shock protein beta-8 (HSPB8) and Bcl-2 associated athanogene 3 (BAG3). In the present study, we examined the autophagy induced by high glucose levels in an in vivo rat model of diabetes induced by streptozotocin (STZ) and an in vitro model of retinal ganglion cell-5 (RGC5) cells under high glucose conditions. In th...
Source: International Journal of Medical Sciences - December 6, 2017 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Downregulation of cathepsin G reduces the activation of CD4+ T cells in murine autoimmune diabetes.
Authors: Zou F, Lai X, Li J, Lei S, Hu L
Abstract
Type 1 diabetes mellitus (T1DM) is an autoimmune disease due to progressive injury of islet cells mediated by T lymphocytes (T cells). Our previous studies have shown that only cathepsin G (CatG), not other proteases, is involved in the antigen presentation of proinsulin, and if the presentation is inhibited, the activation of CD4+ T cells induced by proinsulin is alleviated in T1DM patients, and CatG-specific inhibitor reduces the activation of CD4+ cells induced by proinsulin in T1DM patients. Therefore, we hypothesize that CatG may play an important role in the a...
Source: American Journal of Translational Research - December 10, 2017 Category: Research Tags: Am J Transl Res Source Type: research
FGFR1 is essential for N-acetyl-seryl-aspartyl-lysyl-proline regulation of mitochondrial dynamics by upregulating microRNA let-7b-5p.
Abstract
Fibroblast growth factor receptor (FGFR) 1 plays a key role in endothelial homeostasis by inducing microRNA (miR) let-7. Our previous paper showed that anti-fibrotic effects of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) were associated with restoring diabetes-suppressed expression of FGFR1 and miR let-7, the key contributor of mitochondrial biogenesis, which is regulated by mitochondrial membrane GTPase proteins (MFN2 and OPA1). Here, we found that the FGFR1 signaling pathway was critical for AcSDKP in maintaining endothelial mitochondrial biogenesis through induction of miR let-7b-5p. In endothelial ...
Source: Biochemical and Biophysical Research communications - December 18, 2017 Category: Biochemistry Authors: Hu Q, Li J, Nitta K, Kitada M, Nagai T, Kanasaki K, Koya D Tags: Biochem Biophys Res Commun Source Type: research
Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway
Publication date: Available online 25 December 2017 Source:Pharmacological Research Author(s): Jiting Yan, Changyuan Wang, Yue Jin, Qiang Meng, Qi Liu, Zhihao Liu, Kexin Liu, Huijun Sun Type 2 diabetes is characterized by insulin resistance in target tissues and hyperglycemia. Catalpol is a natural product isolated from the root of Rehmannia glutinosa, which has been reported to produce the effect of anti-diabetes in recent reports. The goal of the current study is to investigate the therapeutic effects of catalpol on hepatic insulin resistance in type 2 diabetes and elucidate the underlying cellular mechanisms. Type 2 di...
Source: Pharmacological Research - December 25, 2017 Category: Drugs & Pharmacology Source Type: research
Expression, distribution and function of kinin B1 receptor in the rat diabetic retina
Conclusion and ImplicationsThis study supports a detrimental role for kinin B1R on endothelial and glial cells in acute and advanced phases of DR. Topical application of the peptide kinin B1R antagonist R‐954 appears a feasible therapeutic approach in the treatment of DR.
Source: British Journal of Pharmacology - December 29, 2017 Category: Drugs & Pharmacology Authors: Soumaya Hachana, Menakshi Bhat, Jacques S énécal, Frédéric Huppé‐Gourgues, Réjean Couture, Elvire Vaucher Tags: RESEARCH PAPER Source Type: research
Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling
AbstractThe activation of NLR family pyrin domain containing 3 (NLRP3) inflammasome have been implicated in the initiation or progression of atherosclerosis. Recent research showed that irisin, a newly discovered adipomiokine, alleviates endothelial dysfunction in type 2 diabetes partiallyvia reducing oxidative/nitrative stresses, suggesting that irisin may be a promising candidate for the treatment of vascular complications of diabetes. However, the association between irisin and NLRP3 inflammasome in the pathogenesis of atherosclerosis remains unclear. In the present study, we cultured human umbilical vein endothelial ce...
Source: Inflammation - January 10, 2018 Category: Allergy & Immunology Source Type: research
14 The mechanism of pkcB-p66shc-nadph oxidase pathway in high glucose induced-oxidative stress in renal tubular epithelial cells
ConclusionThe study clarified a novel mechanism of oxidative stress damaging HK-2 cells via the modulation of the PKCβ-P66Shc-NADPH oxidase pathway. Understanding the molecular pathway of oxidative stress could translate into the development of therapeutic strategies for diabetic nephropathy.AcknowledgementsThis work was supported by the National Natural Science Foundation of China [No. 81400300] and Natural Science Foundation of Jiangsu Province [No. BK20130642].
Source: Journal of Investigative Medicine - December 5, 2017 Category: Research Authors: Cheng, Y., Chao, J., Zhu, D., Liu, B. Tags: Abstracts Source Type: research
Sirt6 mRNA-incorporated endothelial microparticles (EMPs) attenuates DM patient-derived EMP-induced endothelial dysfunction.
Conclusion: The Sirt6 mRNA-carrying EMPs may ameliorate endothelial dysfunction in diabetic patients.
PMID: 29371988 [PubMed]
Source: Oncotarget - January 28, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Expression of MicroRNA-448 and SIRT1 and Prognosis of Obese Type 2 Diabetic Mellitus Patients After Laparoscopic Bariatric Surgery
Conclusion: The results demonstrated that miR-448 and its target gene SIRT1 can serve as prognostic indicators for obese T2DM patients after laparoscopic bariatric surgery.Cell Physiol Biochem 2018;45:935 –950
Source: Cellular Physiology and Biochemistry - February 9, 2018 Category: Cytology Source Type: research
Reactive oxygen species promote tubular injury in diabetic nephropathy: The role of the mitochondrial ros-txnip-nlrp3 biological axis
Publication date: June 2018 Source:Redox Biology, Volume 16 Author(s): Yachun Han, Xiaoxuan Xu, Chengyuan Tang, Peng Gao, Xianghui Chen, Xiaofen Xiong, Ming Yang, Shikun Yang, Xuejing Zhu, Shuguang Yuan, Fuyou Liu, Li Xiao, Yashpal S. Kanwar, Lin Sun NLRP3/IL-1β activation via thioredoxin (TRX)/thioredoxin-interacting protein (TXNIP) following mitochondria ROS (mtROS) overproduction plays a key role in inflammation. However, the involvement of this process in tubular damage in the kidneys of patients with diabetic nephropathy (DN) is unclear. Here, we demonstrated that mtROS overproduction is accompanied by decreases in ...
Source: Redox Biology - February 20, 2018 Category: Biology Source Type: research
