Degree of Functionality and Perception of Health-Related Quality of Life in People with Moderate Stroke: Differences between Ischemic and Hemorrhagic Typology.
Conclusions: Regardless of the stroke type, divergent results were only found in two domains, "vitality" and "mental health." There was an improvement over time, but the scores obtained were still lower than those observed in the normative group, which indicated that the participants' health was highly compromised. This study provides more information for faster rehabilitation after stroke; even so, more studies are needed. PMID: 31182979 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - June 13, 2019 Category: Neurology Authors: Unibaso-Markaida I, Iraurgi I, Ortiz-Marqués N, Martínez-Rodríguez S Tags: Behav Neurol Source Type: research

Medication Belief and Adherence among Patients with Epilepsy.
Conclusion: Majority of the epileptic patients were nonadherent to their medications, and more than one-third of the patients had a negative medication belief. Low medication necessity belief, high medication concern belief, negative medication belief, comorbidity, and seizure encounter were predictors of medication nonadherence. Therefore, healthcare providers should design educational programs to enhance the patients' believe about their medication in order to improve medication adherence and overall treatment outcome. PMID: 31178940 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - June 11, 2019 Category: Neurology Authors: Niriayo YL, Mamo A, Gidey K, Demoz GT Tags: Behav Neurol Source Type: research

Attention Deficit Hyperactivity Disorder (ADHD) among Children Aged 6 to 17 Years Old Living in Girja District, Rural Ethiopia.
Conclusion: The ADHD prevalence rate was found to be similar with global reports. Prevention and early management of maternal complications is important to reduce the prevalence of ADHD among children. PMID: 31110594 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 22, 2019 Category: Neurology Authors: Lola HM, Belete H, Gebeyehu A, Zerihun A, Yimer S, Leta K Tags: Behav Neurol Source Type: research

Psychometric Evaluation of Anxiety, Depression, and Sleep Quality after a Mild Traumatic Brain Injury: A Longitudinal Study.
In conclusion, the mTBI patients showed a gradual improvement of anxiety and depression over the 2 years following injury. While anxiety and depression levels for mTBI patients in general did not return to premorbid status, improvements were observed. Sleep disorders persisted and were consistent with initial levels of distress. PMID: 31110595 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 22, 2019 Category: Neurology Authors: Ma HP, Chen PS, Wong CS, Chang CF, Ou JC, Tsai YR, Chiu WT, Tsai SH, Liao KH, Chiang YH, Wang JY, Chen KY, Wu JC Tags: Behav Neurol Source Type: research

Cognitive Rehabilitation of Acquired Calculation Disturbances.
Abstract Acalculia is an acquired disorder in calculation abilities, usually associated with left posterior parietal damage. Two types of acalculic disorders are usually distinguished: (1) primary acalculia or anarithmetia, where the patient presents a loss of numerical concepts (difficulties are observed both in oral and written calculations), and (2) secondary acalculia due to a different disturbance in cognition and affecting mathematical abilities. Secondary acalculias are associated with aphasia, alexia, agraphia, executive function disorders, or visuospatial difficulties. This paper is a proposal for clinica...
Source: Behavioural Neurology - May 18, 2019 Category: Neurology Authors: Ardila A, Rosselli M Tags: Behav Neurol Source Type: research

Behavioral and Cognitive Impacts of Mindfulness-Based Interventions on Adults with Attention-Deficit Hyperactivity Disorder: A Systematic Review.
Abstract Mindfulness-based interventions (MBIs) are becoming increasingly popular as treatments for physical and psychological problems. Recently, several studies have suggested that MBIs may also be effective in reducing symptoms of attention-deficit hyperactivity disorder (ADHD). Most studies have examined the effectiveness in children, but there are now a sufficient number of individual treatment trials to consider a systematic review in adults. Majority of existing systematic reviews and meta-analyses only consider ADHD symptoms as an outcome, and most of them do not fully report potential biases of included s...
Source: Behavioural Neurology - May 18, 2019 Category: Neurology Authors: Poissant H, Mendrek A, Talbot N, Khoury B, Nolan J Tags: Behav Neurol Source Type: research

Timing of Acupuncture during LTP-Like Plasticity Induced by Paired-Associative Stimulation.
Abstract The aim of this study was to investigate the time-dependent effects of acupuncture on the excitability and long-term potentiation- (LTP-) like plasticity induced by paired-associative stimulation (PAS) over the primary motor cortex (M1). The present examination is the first to report the influence of acupuncture on the motor-evoked potential (MEP) throughout the treatment process, including baseline (before acupuncture), the needle in situ, and the needle removal. Subsequently, the LTP-like plasticity induced by paired-associative stimulation (PAS) was explored, which consisted of 200 pairs of electrical ...
Source: Behavioural Neurology - May 18, 2019 Category: Neurology Authors: He XK, Sun QQ, Liu HH, Guo XY, Chen C, Chen LD Tags: Behav Neurol Source Type: research

Probable RBD Associates with the Development of RLS in Parkinson's Disease: A Cross-Sectional Study.
Conclusion: PRBD existence, daily LED, and HAMD scores are independent factors for developing RLS in PD patients. PRBD existence is firstly proposed as an independent factor in developing RLS among PD patients. RLS severity in PD patients are positively associated with the duration of PD and daily LED. PMID: 31065297 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2019 Category: Neurology Authors: Qu Y, Zhang L, Shen D, Zhang W, Zhang M, Pan Y Tags: Behav Neurol Source Type: research

Frontal Anatomical Correlates of Cognitive and Speech Motor Deficits in Amyotrophic Lateral Sclerosis.
Abstract The goal of this study was to identify neurostructural frontal lobe correlates of cognitive and speaking rate changes in amyotrophic lateral sclerosis (ALS). 17 patients diagnosed with ALS and 12 matched controls underwent clinical, bulbar, and neuropsychological assessment and structural neuroimaging. Neuropsychological testing was performed via a novel computerized frontal battery (ALS-CFB), based on a validated theoretical model of frontal lobe functions, and focused on testing energization, executive function, emotion processing, theory of mind, and behavioral inhibition via antisaccades. The measure ...
Source: Behavioural Neurology - April 21, 2019 Category: Neurology Authors: Yunusova Y, Ansari J, Ramirez J, Shellikeri S, Stanisz GJ, Black SE, Gillingham SM, Kiss A, Stuss DT, Zinman L Tags: Behav Neurol Source Type: research

The Clinical and Vascular Characteristics of RNF213 c.14576G > A Variant-Related Intracranial Major Artery Disease in China.
The Clinical and Vascular Characteristics of RNF213 c.14576G>A Variant-Related Intracranial Major Artery Disease in China. Behav Neurol. 2019;2019:7908392 Authors: Cheng W, Xue S, Wu F, Song X, Huang Q, Song H, Wu J Abstract Background and Purpose: Recently, several studies indicated the c.14576G>A variant on the ring finger protein 213 (RNF213), a founder variant of moyamoya diseases (MMD), was associated with non-MMD intracranial major artery stenosis/occlusion (non-MMD ICASO). We proposed that RNF213 variant-related ICASO including MMD might be a special entity with its own characteristics ba...
Source: Behavioural Neurology - April 18, 2019 Category: Neurology Authors: Cheng W, Xue S, Wu F, Song X, Huang Q, Song H, Wu J Tags: Behav Neurol Source Type: research

Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid- β Deposition and Acute Cognitive Deficits in Mice.
Traumatic Brain Injury by Weight-Drop Method Causes Transient Amyloid-β Deposition and Acute Cognitive Deficits in Mice. Behav Neurol. 2019;2019:3248519 Authors: Shishido H, Ueno M, Sato K, Matsumura M, Toyota Y, Kirino Y, Tamiya T, Kawai N, Kishimoto Y Abstract There has been growing awareness of the correlation between an episode of traumatic brain injury (TBI) and the development of Alzheimer's disease (AD) later in life. It has been reported that TBI accelerated amyloid-β (Aβ) pathology and cognitive decline in the several lines of AD model mice. However, the short-term and long-ter...
Source: Behavioural Neurology - April 5, 2019 Category: Neurology Authors: Shishido H, Ueno M, Sato K, Matsumura M, Toyota Y, Kirino Y, Tamiya T, Kawai N, Kishimoto Y Tags: Behav Neurol Source Type: research

The Incidence of Diagnosis of Munchausen Syndrome, Other Factitious Disorders, and Malingering.
Conclusions: There is a male predominance for the diagnosis of malingering. An earlier suspicion of a female predominance for Munchausen syndrome is upheld. There is significant underdiagnosing and misdiagnosing for both conditions and for factitious disorders in general. To separate the most serious form of factitious disorders from milder forms and to facilitate more systematic research, we recommend a specific ICD diagnosis for Munchausen syndrome. PMID: 30944662 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - April 5, 2019 Category: Neurology Authors: Schrader H, Bøhmer T, Aasly J Tags: Behav Neurol Source Type: research

A Repeated Measures Pilot Comparison of Trajectories of Fluctuating Endogenous Hormones in Young Women with Traumatic Brain Injury, Healthy Controls.
Conclusion: Acute TBI may suppress E2 and increase CORT in young women. OCs appeared to independently affect CORT and FSH responses. Future work is needed with a larger sample to characterize TBI effects on women's endogenous hormone response to injury and OC use's effects on post-TBI stress response and gonadal function, as well as secondary injury. PMID: 30891100 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - March 22, 2019 Category: Neurology Authors: Niemeier JP, Perrin PB, Hurst BS, Foureau DM, Huynh TT, Evans SL, Silverman JE, Elise McClannahan M, Brusch BD, Newman M, Mougeot JL, Wagner AK Tags: Behav Neurol Source Type: research

Cognitive and Emotional Empathy in Individuals with Spinal Cord Injury.
Conclusion: Results suggest that SCI patients, when analyzing the meaning of emotional stimuli, tend to rely on a cognitive empathy strategy rather than on emotion simulation. PMID: 30881519 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - March 19, 2019 Category: Neurology Authors: Guadagni V, Sarà M, Conson M, Carolei A, Sacco S, Vadini S, Pistarini C, Barbonetti A, Iaria G, Pistoia F Tags: Behav Neurol Source Type: research

Screening for Problematic Internet Use May Help Identify Impulse Control Disorders in Parkinson's Disease.
Conclusions: Our study suggests that the screening for problematic Internet use by the Problematic Internet Use Questionnaire is an effective, feasible, and easy-to-use add-on method for identifying PD patients with impulse control disorders more efficiently and probably at earlier stages. PMID: 30863462 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - March 15, 2019 Category: Neurology Authors: Kovács M, Makkos A, Pintér D, Juhász A, Darnai G, Karádi K, Janszky J, Kovács N Tags: Behav Neurol Source Type: research

Assessing Treatment Fidelity within an Epilepsy Randomized Controlled Trial: Seizure First Aid Training for People with Epilepsy Who Visit Emergency Departments.
Conclusions: The fidelity measures used were reliable and showed that the intervention was delivered as attended. Therefore, any estimates of intervention effect will not be influenced by poor implementation fidelity. PMID: 30863463 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - March 15, 2019 Category: Neurology Authors: Noble AJ, Snape D, Ridsdale L, Morgan M, Nevitt SJ, Goodacre S, Marson A Tags: Behav Neurol Source Type: research

The Effect of Metformin in Experimentally Induced Animal Models of Epileptic Seizure.
Conclusion: This review revealed the benefits of metformin in alleviating symptoms of epileptic seizure and modifying different cellular and molecular changes that affect the natural history of the disease in addition to its good safety profile. PMID: 30863464 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - March 15, 2019 Category: Neurology Authors: Yimer EM, Surur A, Wondafrash DZ, Gebre AK Tags: Behav Neurol Source Type: research

Influence of Environmental Factors on Social Participation Post-Stroke.
Conclusions: Perceived social support was found to predict social participation in individuals living in the community 6 months or greater post-stroke. Focusing on social support during post-stroke rehabilitation may provide an avenue for increased social participation and more successful community reintegration. PMID: 30800187 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - February 27, 2019 Category: Neurology Authors: Foley EL, Nicholas ML, Baum CM, Connor LT Tags: Behav Neurol Source Type: research

Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion.
ron;imić G Abstract Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum. The neuropathological correlate of FTD is frontotemporal lobar degeneration (FTLD), characterized by tau-, TDP-43-, and FUS-immunoreactive neuronal inclusions. An earlier discovery that a hexanucleotide repeat expansion mutation in chromosome 9 open reading frame 72 (C9orf72) gene causes ALS and FTD established a special subtype of ALS and FTLD with TDP-43 pathology (C9FTD/ALS). Normal individuals carry 2-10 hexanucleoti...
Source: Behavioural Neurology - February 20, 2019 Category: Neurology Authors: Babić Leko M, Župunski V, Kirincich J, Smilović D, Hortobágyi T, Hof PR, Šimić G Tags: Behav Neurol Source Type: research

Psychiatric Assessment in Patients with Mild Temporal Lobe Epilepsy.
Conclusions: Our findings suggest that different personality traits may play a role in determining the clinical outcome in patients with mTLE. Specifically, lower scores of HA, RD, P, C, and ST were associated with worse clinical outcome. Thus, personality assessment could serve as an early indicator of greater disease severity, improving the management of mTLE. PMID: 30733834 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - February 10, 2019 Category: Neurology Authors: Bruni A, Martino I, Caligiuri ME, Vaccaro MG, Trimboli M, Segura Garcia C, De Fazio P, Gambardella A, Labate A Tags: Behav Neurol Source Type: research

Visuoperceptual Impairment in Children with NF1: From Early Visual Processing to Procedural Strategies.
Abstract Visual-spatial impairment has long been considered a hallmark feature of neurofibromatosis type 1 (NF1). No study investigating the cognitive and neuropsychological profile of NF1 used the Rey Complex Figure Test (RCFT) task as the primary measure of visual-perceptual abilities taking into consideration all functions involved including the strategic processing style. We compared 18 children with NF1, 17 siblings (S), and 18 typically developing children (TD) at intelligence scale and RCFT copy, recall, and recognition trials; we also evaluated the copy strategy as a measure of a visual-processing style. C...
Source: Behavioural Neurology - February 10, 2019 Category: Neurology Authors: Bulgheroni S, Taddei M, Saletti V, Esposito S, Micheli R, Riva D Tags: Behav Neurol Source Type: research

Mechanisms Underlying Aggressive Behavior Induced by Antiepileptic Drugs: Focus on Topiramate, Levetiracetam, and Perampanel.
Abstract Antiepileptic drugs (AEDs) are effective against seizures, but their use is often limited by adverse effects, among them psychiatric and behavioral ones including aggressive behavior (AB). Knowledge of the incidence, risk factors, and the underlying mechanisms of AB induced by AEDs may help to facilitate management and reduce the risk of such side effects. The exact incidence of AB as an adverse effect of AEDs is difficult to estimate, but frequencies up to 16% have been reported. Primarily, levetiracetam (LEV), perampanel (PER), and topiramate (TPM), which have diverse mechanisms of action, have been ass...
Source: Behavioural Neurology - December 25, 2018 Category: Neurology Authors: Hansen CC, Ljung H, Brodtkorb E, Reimers A Tags: Behav Neurol Source Type: research

Behavioural and Cognitive Changes in Lewy Body Dementias.
PMID: 30534208 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - December 12, 2018 Category: Neurology Authors: Kung WM, Ho YJ, Yoshizawa H, Matsuo S, Wei CY Tags: Behav Neurol Source Type: research

Longitudinal Screening Detects Cognitive Stability and Behavioral Deterioration in ALS Patients.
Abstract Objective: To evaluate longitudinal cognitive/behavioral change over 12 months in participants enrolled in the ALS Multicenter Cohort Study of Oxidative Stress (ALS COSMOS). Methods: We analyzed data from 294 ALS participants, 134 of whom were studied serially. Change over time was evaluated controlling for age, sex, symptom duration, education, race, and ethnicity. Using multiple regression, we evaluated associations among decline in ALS Functional Rating Scale-Revised (ALSFRS-R) scores, forced vital capacity (FVC), and cognitive/behavioral changes. Change in cognitive/behavioral subgroups was asses...
Source: Behavioural Neurology - December 7, 2018 Category: Neurology Authors: Woolley S, Goetz R, Factor-Litvak P, Murphy J, Hupf J, Lomen-Hoerth C, Andrews H, Heitzman D, Bedlack R, Katz J, Barohn R, Sorenson E, Oskarsson B, Filho AF, Kasarskis E, Mozaffar T, Nations S, Swenson A, Koczon-Jaremko A, Christodoulou G, Mitsumoto H Tags: Behav Neurol Source Type: research

Therapeutic Strategies for Poststroke Neurological Behavior: From Molecular to Cellular.
PMID: 30510600 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - December 5, 2018 Category: Neurology Authors: Tang H, Manaenko A, Hu Q Tags: Behav Neurol Source Type: research

Apathy Is Correlated with Widespread Diffusion Tensor Imaging (DTI) Impairment in Amyotrophic Lateral Sclerosis.
elo G Abstract Apathy is recognized as the most common behavioral change in several neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS), a multisystem neurodegenerative disorder. Particularly, apathy has been reported to be associated with poor ALS prognosis. However, the brain microstructural correlates of this behavioral symptom, reported as the most common in ALS, have not been completely elucidated. Using diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS), here we aimed to quantify the correlation between brain microstructural damage and apathy scores in the early st...
Source: Behavioural Neurology - November 15, 2018 Category: Neurology Authors: Femiano C, Trojsi F, Caiazzo G, Siciliano M, Passaniti C, Russo A, Bisecco A, Cirillo M, Monsurrò MR, Esposito F, Tedeschi G, Santangelo G Tags: Behav Neurol Source Type: research

Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up.
Abstract Narcolepsy type 1 is a rare disabling sleep disorder mainly characterized by excessive daytime sleepiness and cataplexy, an emotion-triggered sudden loss of muscle tone. Patients have a selective degeneration of hypocretin-producing neurons in the dorsolateral posterior hypothalamus with growing evidence supporting the hypothesis of an autoimmune mechanism. Few case studies that reported intravenous immunoglobulin therapy (IVIg) suggest the efficacy of IVIg when administered early after disease onset, but the results are controversial. In these retrospective case observations, IVIg cycles were initiated w...
Source: Behavioural Neurology - November 11, 2018 Category: Neurology Authors: Ruppert E, Zagala H, Chambe J, Comtet H, Kilic-Huck U, Lefebvre F, Bataillard M, Schroder C, Calvel L, Bourgin P Tags: Behav Neurol Source Type: research

Stroke Survivor and Caregiver Perspectives on Post-Stroke Visual Concerns and Long-Term Consequences.
This study employed a qualitative design using semistructured interviews conducted with a convenience sample of stroke survivors and caregivers recruited from either a community support group or skilled nursing and long-term care facilities. Interviews were recorded and transcribed verbatim. Comparative content analysis was used to identify vision-related themes by two independent coders. All research team members completed quality checking of coding. Twenty participants (11 stroke survivors and 9 caregivers) expressed visual concerns or consequences following stroke: (1) eye movement problems, (2) perceptual issues, and (...
Source: Behavioural Neurology - November 8, 2018 Category: Neurology Authors: Smith TM, Pappadis MR, Krishnan S, Reistetter TA Tags: Behav Neurol Source Type: research

Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice.
Abstract Crinum macowanii is a bulbous plant indigenous to many parts of Southern Africa. Extracts of C. macowanii have gained interest since the discovery of various alkaloids, few of which possess acetylcholinesterase inhibitory activity. The present study was performed to evaluate the effect of a crude hydroethanolic extract of C. macowanii against aluminum chloride-induced memory impairment in mice using the Morris water maze and the novel object recognition task. C. macowanii (10, 20, and 40 mg/kg p.o) was administered daily for five weeks, while donepezil (3 mg/kg p.o) was used as the positive ...
Source: Behavioural Neurology - November 8, 2018 Category: Neurology Authors: Jilani MS, Tagwireyi D, Gadaga LL, Maponga CC, Mutsimhu C Tags: Behav Neurol Source Type: research

Associations between Attention-Deficit Hyperactivity Disorder (ADHD) Treatment and Patient Nutritional Status and Height.
Abstract Attention-deficit hyperactivity disorder (ADHD) has been found to co-occur frequently with obesity, although the reasons for this association are unknown. The aim of this study was to compare the nutritional profile of a Brazilian cohort of ADHD patients with that of the general population and to analyze the association between ADHD drug treatment (with methylphenidate), nutritional status, and height of these individuals. In the first phase of the study, we designed the nutritional and height profile of 93 ADHD patients (5.1 to 13.8 years old) and compared it to a control group. In the second phase, we a...
Source: Behavioural Neurology - November 4, 2018 Category: Neurology Authors: Granato MF, Ferraro AA, Lellis DM, Casella EB Tags: Behav Neurol Source Type: research

Comparing Sensitivity and Specificity of Addenbrooke's Cognitive Examination-I, III and Mini-Addenbrooke's Cognitive Examination in Parkinson's Disease.
Conclusion: ACE-III and its nested version, the Mini-ACE, had the best screening abilities for detecting mild and major NCD in PD. PMID: 30369997 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - October 31, 2018 Category: Neurology Authors: Lucza T, Ascherman Z, Kovács M, Makkos A, Harmat M, Juhász A, Janszky J, Komoly S, Kovács N, Dorn K, Karádi K Tags: Behav Neurol Source Type: research

Effects of Ficus umbellata (Moraceae) Aqueous Extract and 7-Methoxycoumarin on Scopolamine-Induced Spatial Memory Impairment in Ovariectomized Wistar Rats.
n D Abstract The present work was undertaken to evaluate the ability of F. umbellata aqueous extract and its major component 7-methoxycoumarin (MC) to improve scopolamine-induced spatial memory impairment in ovariectomized Wistar rats. For this to be done, 10 sham-operated and 30 postmenopausal-like rats were randomly distributed in eight groups (n = 5) and treated with distilled water (2 mL/250 g), estradiol valerate (1 mg/kg BW), piracetam (1.5 mg/kg BW), F. umbellata aqueous extract (50 and 200 mg/kg BW), or MC (1 mg/kg BW) for 21 consecutive days. Before and after the ...
Source: Behavioural Neurology - October 28, 2018 Category: Neurology Authors: Zingue S, Foyet HS, Djiogue S, Ezo'o Ezo'o Y, Abaïssou HHN, Fachagbo P, Njamen D Tags: Behav Neurol Source Type: research

Gait and Conditioned Fear Impairments in a Mouse Model of Comorbid TBI and PTSD.
Conclusions: These results indicate that SPS paired with CCI in mice produces unique behavioral impairments in gait and fear recall that are not present in either condition alone. Further studies are underway to examine additional behavioral, physiological, and pathological phenotypes in this combined model of TBI + PTSD. PMID: 30327687 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - October 19, 2018 Category: Neurology Authors: Teutsch P, Jones CE, Kaiser ME, Avalon Gardner N, Lim MM Tags: Behav Neurol Source Type: research

The Long-Term Efficacy and Safety of Carotid Artery Stenting among the Elderly: A Single-Center Study in China.
Abstract Compared to carotid endarterectomy, carotid artery stenting (CAS) is reportedly associated with higher perioperative risks in elderly patients. To verify the long-term safety and efficacy of CAS with embolic protection in elderly patients, we retrospectively reviewed the medical records of patients with carotid stenosis treated between January 2003 and March 2010 at the Department of Neurology of a large university hospital in China. We included patients with symptomatic, moderate, or severe carotid stenosis of atherosclerotic etiology (other etiologies were excluded), with a disability score ≤&...
Source: Behavioural Neurology - October 11, 2018 Category: Neurology Authors: Wen L, Wang S, Liu L, Chen L, Geng J, Kuang L, Qian G, Su J, Chen K, Zhou Z Tags: Behav Neurol Source Type: research

Scoping Review: The Trajectory of Recovery of Participation Outcomes following Stroke.
Abstract Participation is a central concept in health and well-being and healthcare, yet operationalizing this concept has been difficult. Its definition, uses in healthcare, and impacts on recovery require ongoing research. Our review question goes like this: from the longitudinal evidence investigating participation among stroke survivors, what are the patterns of participation recovery in stroke survivors over time, and what interventions are used to improve participation? To fully understand these questions, we also ask, how is participation defined in the stroke literature, and what are the measures of partic...
Source: Behavioural Neurology - October 4, 2018 Category: Neurology Authors: Engel-Yeger B, Tse T, Josman N, Baum C, Carey LM Tags: Behav Neurol Source Type: research

Altered Small-World Networks in First-Episode Schizophrenia Patients during Cool Executive Function Task.
Abstract At present, little is known about brain functional connectivity and its small-world topologic properties in first-episode schizophrenia (SZ) patients during cool executive function task. In this paper, the Trail Making Test-B (TMT-B) task was used to evaluate the cool executive function of first-episode SZ patients and electroencephalography (EEG) data were recorded from 14 first-episode SZ patients and 14 healthy controls during this cool executive function task. Brain functional connectivity between all pairs of EEG channels was constructed based on mutual information (MI) analysis. The constructed brai...
Source: Behavioural Neurology - September 28, 2018 Category: Neurology Authors: Zhao Z, Cheng Y, Li Z, Yu Y Tags: Behav Neurol Source Type: research

Indication of Disrupted Temporal Structure in the Case of Thought Blocks in Schizophrenia: The Role of the Metastable Balance.
This study is aimed at investigating probable disruption of the metastable balance relevant to a disruption of the mental processes observed in the neurophenomenal level. This disruption was found to occur under dense auditory verbal hallucinations (AVHs) which are accompanied by thought blocking (TB) phenomena. The entropy that quantifies the complexity of the spontaneous coupling has been used to describe the observed transitions. According to our findings, the high synchrony-derived entropy (SE) defines a metastable state, where formations of cortical areas are able to coordinate transiently under the demands of stimulu...
Source: Behavioural Neurology - September 25, 2018 Category: Neurology Authors: Koutsoukos E, Angelopoulos E Tags: Behav Neurol Source Type: research

Scoping Review of the Driving Behaviour of and Driver Training Programs for People on the Autism Spectrum.
Abstract Gaining a driver's licence represents increased independence and can lead to improved quality of life for individuals and their families. Learning to drive a motor vehicle and maintaining safe on-road skills are often more difficult for people on the autism spectrum. Many countries currently have no autism-specific licencing requirements for learner drivers, and there is a general lack of ASD-specific support and training packages for individuals, their families, and driving instructors. This review synthesises the peer-reviewed literature about the driving characteristics of drivers on the spectrum and d...
Source: Behavioural Neurology - September 25, 2018 Category: Neurology Authors: Wilson NJ, Lee HC, Vaz S, Vindin P, Cordier R Tags: Behav Neurol Source Type: research

Effect of Carotid Artery Morphological Variations on Cognitive Function.
This study is aimed at investigating whether carotid artery morphological variations (CAMV) cause cognitive impairment. Methods: Hospitalized patients from March 2017 to October 2017 who underwent digital subtract angiography (DSA) were divided into non-CAMV group, T-type group, K-type group, and C-type group according to their carotid artery morphology. Cognitive function in each group was evaluated with the Mini-Mental State Scale (MMSE), the Montreal Cognitive Assessment (MoCA), the Verbal Fluency Test (VFT), and the Digital Span Test (DST). Results: A total of 96 patients were included in the study (32 in non...
Source: Behavioural Neurology - September 8, 2018 Category: Neurology Authors: Chen L, Huang J, Wang S, Ran H, Wen L, Chen K, Zhou Z Tags: Behav Neurol Source Type: research

Hypertriglyceridemia Is Associated with Reduced Leukoaraiosis Severity in Patients with a Small Vessel Stroke.
Abstract Intracranial hemorrhage or microbleeds and leukoaraiosis have an overlap in biology. Hyperlipidemia may reduce the risk of ICH or cerebral microbleeds; studies focusing on the relationship between different lipid profiles and severity of periventricular hyperintensities (PVH) and subcortical white matter lesions (SWMLs) in the cerebral small vessel disease are limited. Methods. Patients with recent first lacunar infarct were recruited. PVH and SWMLs were accessed on MRI with the Fazekas scale, and lipid levels were measured. Univariate and multivariable regression analyses were used to assess the relation...
Source: Behavioural Neurology - September 1, 2018 Category: Neurology Authors: Ke D, Zhou F, Liang H, Xu Y, Lou H Tags: Behav Neurol Source Type: research

Histone Deacetylase Inhibitor Scriptaid Alleviated Neurological Dysfunction after Experimental Intracerebral Hemorrhage in Mice.
Abstract Objectives: To investigate the role of Scriptaid in reducing brain injury after intracerebral hemorrhage (ICH) in mice. Methods: An ICH model was constructed by injecting autologous blood into the right basal ganglia in mice. The animals were administered 3.5 mg/kg of Scriptaid intraperitoneally after ICH. The hematoma volume and hemoglobin level were measured to examine hematoma resolution. A behavior test and brain edema and white matter injury examinations indicated brain injury after ICH. Results: Scriptaid treatment promoted hematoma resolution and reduced the hematoma volume 7&thins...
Source: Behavioural Neurology - September 1, 2018 Category: Neurology Authors: Yang H, Ni W, Jiang H, Lei Y, Su J, Gu Y, Zhou L Tags: Behav Neurol Source Type: research

Exploring the Neuroplastic Effects of Biofeedback Training on Smokers.
Abstract Smoking and stress cooccur in different stages of a nicotine addiction cycle, affecting brain function and showing additive impact on different physiological responses. Resting-state functional connectivity has shown potential in identifying these alterations. Nicotine addiction has been associated with detrimental effects on functional integrity of the central nervous system, including the organization of resting-state networks. Prolonged stress may result in enhanced activation of the default mode network (DMN). Considering that biofeedback has shown promise in alleviating physiological manifestations o...
Source: Behavioural Neurology - August 30, 2018 Category: Neurology Authors: Pandria N, Athanasiou A, Terzopoulos N, Paraskevopoulos E, Karagianni M, Styliadis C, Kourtidou-Papadeli C, Pataka A, Lymperaki E, Bamidis PD Tags: Behav Neurol Source Type: research

Ceftriaxone Treatment for Neuronal Deficits: A Histological and MEMRI Study in a Rat Model of Dementia with Lewy Bodies.
Abstract Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density...
Source: Behavioural Neurology - August 30, 2018 Category: Neurology Authors: Ho YJ, Weng JC, Lin CL, Shen MS, Li HH, Liao WC, Tsai NM, Hung CS, Lai TJ, Lee IY Tags: Behav Neurol Source Type: research

Inhibiting of GRASP65 Phosphorylation by DL-3-N-Butylphthalide Protects against Cerebral Ischemia-Reperfusion Injury via ERK Signaling.
Conclusions: The current finding suggested that NBP protected the cerebrum from CIRI mediated by inhibiting the ERK signaling pathway and subsequently reducing GRASP65 phosphorylation. PMID: 30154935 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 30, 2018 Category: Neurology Authors: Zhu BL, Xie CL, Hu NN, Zhu XB, Liu CF Tags: Behav Neurol Source Type: research

Behavioural and Cognitive Changes in Neurodegenerative Diseases and Brain Injury.
antangelo G PMID: 30147810 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 29, 2018 Category: Neurology Authors: Trojsi F, Christidi F, Migliaccio R, Santamaría-García H, Santangelo G Tags: Behav Neurol Source Type: research

The Pathogenesis of Necroptosis-Dependent Signaling Pathway in Cerebral Ischemic Disease.
Abstract Necroptosis is the best-described form of regulated necrosis at present, which is widely recognized as a component of caspase-independent cell death mediated by the concerted action of receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3). Mixed-lineage kinase domain-like (MLKL) was phosphorylated by RIPK3 at the threonine 357 and serine 358 residues and then formed tetramers and translocated onto the plasma membrane, which destabilizes plasma membrane integrity leading to cell swelling and membrane rupture. Necroptosis is downstream of the tumor necrosis factor (...
Source: Behavioural Neurology - August 26, 2018 Category: Neurology Authors: Xu Y, Zhang J, Ma L, Zhao S, Li S, Huang T, Chu Z Tags: Behav Neurol Source Type: research

Increased Risk of Dementia in Patients with Antidepressants: A Meta-Analysis of Observational Studies.
Abstract Antidepressants are the most commonly and widely used medication for its effectiveness in the treatment of anxiety and depression. A few epidemiological studies have documented that antidepressant is associated with increased risk of dementia so far. Here, our aim is to assess the association between antidepressant use and risk of dementia in elderly patients. We searched articles through MEDLINE, EMBASE, Google, and Google Scholar from inception to December 1, 2017, that reported on the association between antidepressant use and dementia risk. Data were collected from each study independently, and study ...
Source: Behavioural Neurology - August 22, 2018 Category: Neurology Authors: Wang YC, Tai PA, Poly TN, Islam MM, Yang HC, Wu CC, Li YJ Tags: Behav Neurol Source Type: research

Corrigendum to "Mechanism of Restoration of Forelimb Motor Function after Cervical Spinal Cord Hemisection in Rats: Electrophysiological Verification".
Corrigendum to "Mechanism of Restoration of Forelimb Motor Function after Cervical Spinal Cord Hemisection in Rats: Electrophysiological Verification". Behav Neurol. 2018;2018:5627890 Authors: Takeuchi T, Takahashi M, Satomi K, Ohne H, Hasegawa A, Sato S, Ichimura S Abstract [This corrects the article DOI: 10.1155/2017/7514681.]. PMID: 30123387 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 22, 2018 Category: Neurology Authors: Takeuchi T, Takahashi M, Satomi K, Ohne H, Hasegawa A, Sato S, Ichimura S Tags: Behav Neurol Source Type: research

PPAR- γ Promotes Hematoma Clearance through Haptoglobin-Hemoglobin-CD163 in a Rat Model of Intracerebral Hemorrhage.
Conclusions: PPAR-γ promotes hematoma clearance and plays a protective role through the Hp-Hb-CD163 pathway in a rat collagenase infusion ICH model. PMID: 30123388 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 22, 2018 Category: Neurology Authors: Wang G, Li T, Duan SN, Dong L, Sun XG, Xue F Tags: Behav Neurol Source Type: research

Hand Dexterity Impairment in Patients with Cervical Myelopathy: A New Quantitative Assessment Using a Natural Prehension Movement.
Abstract Cervical myelopathy (CM) caused by spinal cord compression can lead to reduced hand dexterity. However, except for the 10 sec grip-and-release test, there is no objective assessment system for hand dexterity in patients with CM. Therefore, we evaluated the hand dexterity impairment of patients with CM objectively by asking them to perform a natural prehension movement. Twenty-three patients with CM and 30 age-matched controls were asked to reach for and grasp a small object with their right thumb and index finger and to subsequently lift and hold it. To examine the effects of tactile afferents from...
Source: Behavioural Neurology - August 5, 2018 Category: Neurology Authors: Omori M, Shibuya S, Nakajima T, Endoh T, Suzuki S, Irie S, Ariyasu R, Unenaka S, Sano H, Igarashi K, Ichimura S, Ohki Y Tags: Behav Neurol Source Type: research