Pain in Parkinson's Disease Associated with COMT Gene Polymorphisms.
Conclusion. PD patients possess a high prevalence of pain. Dystonia pain was the most frequent type of PD-related pain. COMT gene rs6267 allele "T" associated with PD pain. PD pain was influenced by disease severity and depression. PD onsets earlier in patients with PD-related pain than non-PD-related pain. PMID: 24825955 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Li W, Chen Y, Yin B, Zhang L Tags: Behav Neurol Source Type: research

The nature of lexical-semantic access in bilingual aphasia.
Conclusions. Differences between bilingual patients and controls demonstrate a fundamental lexical retrieval deficit in bilingual individuals with aphasia, but one that is further influenced by language proficiency in the two languages. PMID: 24825956 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Kiran S, Balachandran I, Lucas J Tags: Behav Neurol Source Type: research

Behavioural and psychological symptoms in poststroke vascular cognitive impairment.
Conclusion. Depression was the commonest neuropsychiatric symptom in VCI. The neuropsychiatric profiles of MID and SIVD were similar. The frequency and severity of apathy and the net burden of BPSD increased with increasing cognitive impairment. PMID: 24825957 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Gupta M, Dasgupta A, Khwaja GA, Chowdhury D, Patidar Y, Batra A Tags: Behav Neurol Source Type: research

Semantic Dementia Shows both Storage and Access Disorders of Semantic Memory.
Conclusions. These results suggest that SD patients have both storage and access disorders and have more severe access disorder than patients with AD. PMID: 24825958 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Takahashi Y, Meguro K, Nakatsuka M, Kasai M, Akanuma K, Yamaguchi S Tags: Behav Neurol Source Type: research

Functional Assessment of Region-Specific Neglect: Are There Differential Behavioural Consequences of Peripersonal versus Extrapersonal Neglect?
Conclusions. When diagnosing neglect, it is relevant to distinguish the type of region-specific neglect and, where needed, to adjust the rehabilitation program accordingly. As the CBS is not developed to typically measure ADL in extrapersonal neglect, it would be of importance to add other (instrumental) activities that heavily rely on processing information in farther space. PMID: 24825959 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Nijboer TC, Ten Brink AF, Kouwenhoven M, Visser-Meily JM Tags: Behav Neurol Source Type: research

Bipolar disorder and multiple sclerosis: a case series.
Conclusions. MRI lesions suggest the possible implication of local MS-related brain damage in development of pure "psychiatric fits" in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits. PMID: 24825960 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Sidhom Y, Ben Djebara M, Hizem Y, Abdelkefi I, Kacem I, Gargouri A, Gouider R Tags: Behav Neurol Source Type: research

A Case of REM Sleep Behavior Disorder, Narcolepsy-Cataplexy, Parkinsonism, and Rheumatoid Arthritis.
Abstract A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, video-polysomnography, multiple sleep latency test, cerebral magnetic resonance imaging, and dopamine transporter imaging by single-photon emission computerized tomography. The patient was found to present for almost two decades, in addition to RBD, also narcolepsy. Moreover, a late development of pa...
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Cosentino FI, Distefano A, Plazzi G, Schenck CH, Ferri R Tags: Behav Neurol Source Type: research

"The mind is its own place": amelioration of claustrophobia in semantic dementia.
"The mind is its own place": amelioration of claustrophobia in semantic dementia. Behav Neurol. 2014;2014:584893 Authors: Clark CN, Downey LE, Golden HL, Fletcher PD, de Silva R, Cifelli A, Warren JD Abstract Phobias are among the few intensely fearful experiences we regularly have in our everyday lives, yet the brain basis of phobic responses remains incompletely understood. Here we describe the case of a 71-year-old patient with a typical clinicoanatomical syndrome of semantic dementia led by selective (predominantly right-sided) temporal lobe atrophy, who showed striking amelioration of p...
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Clark CN, Downey LE, Golden HL, Fletcher PD, de Silva R, Cifelli A, Warren JD Tags: Behav Neurol Source Type: research

Aphasia Therapy in the Age of Globalization: Cross-Linguistic Therapy Effects in Bilingual Aphasia.
Discussion. The potential for CLT of therapy effects from the treated to the untreated language depends on the word type, the degree of structural overlap between languages, the type of therapy approach, the pre- and postmorbid language proficiency profiles, and the status of the cognitive control circuit. PMID: 24825963 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Ansaldo AI, Saidi LG Tags: Behav Neurol Source Type: research

Evaluation of incidence and clinical features of antibody-associated autoimmune encephalitis mimicking dementia.
Conclusions. Our study showed for the first time the presence of parkinsonism and RBD in an anti-NMDAR encephalitis patient mimicking DLB. Although autoimmune encephalitis patients may occasionally present with cognitive decline, most dementia patients do not exhibit anti-neuronal antibodies, suggesting that routine analysis of these antibodies in dementia is not mandatory, even though they display atypical features. PMID: 24825964 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Coban A, Ismail Küçükali C, Bilgiç B, Yalçınkaya N, Haytural H, Ulusoy C, Turan S, Cakır S, Uçok A, Unübol H, Hanagasi HA, Gürvit H, Tüzün E Tags: Behav Neurol Source Type: research

Effect of age, education, and bilingualism on confrontation naming in older illiterate and low-educated populations.
Abstract We investigated the effects of age as well as the linked factors of education and bilingualism on confrontation naming in rural Kashmir by creating a culturally appropriate naming test with pictures of 60 objects. We recruited 48 cognitively normal participants whose ages ranged from 18 to 28 and from 60 to 85. Participants in our study were illiterate monolinguals (N = 18) and educated Kashmiri-Urdu bilinguals (N = 30). Hierarchical multiple regression revealed that younger adults performed better than older adults (P
Source: Behavioural Neurology - May 19, 2014 Category: Neurology Authors: Ashaie S, Obler L Tags: Behav Neurol Source Type: research

Dyscalculia, dysgraphia, and left-right confusion from a left posterior peri-insular infarct.
Abstract The Gerstmann syndrome of dyscalculia, dysgraphia, left-right confusion, and finger agnosia is generally attributed to lesions near the angular gyrus of the dominant hemisphere. A 68-year-old right-handed woman presented with sudden difficulty completing a Sudoku grid and was found to have dyscalculia, dysgraphia, and left-right confusion. Magnetic resonance imaging (MRI) showed a focus of abnormal reduced diffusivity in the left posterior insula and temporoparietal operculum consistent with acute infarct. Gerstmann syndrome from an insular or peri-insular lesion has not been described in the literature p...
Source: Behavioural Neurology - May 13, 2014 Category: Neurology Authors: Bhattacharyya S, Cai X, Klein JP Tags: Behav Neurol Source Type: research

Why Are the Right and Left Hemisphere Conceptual Representations Different?
Abstract The present survey develops a previous position paper, in which I suggested that the multimodal semantic impairment observed in advanced stages of semantic dementia is due to the joint disruption of pictorial and verbal representations, subtended by the right and left anterior temporal lobes, rather than to the loss of a unitary, amodal semantic system. The main goals of the present review are (a) to survey a larger set of data, in order to confirm the differences in conceptual representations at the level of the right and left hemispheres, (b) to examine if language-mediated information plays a greater r...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Gainotti G Tags: Behav Neurol Source Type: research

Effect of aneurysmal subarachnoid hemorrhage on word generation.
Conclusions. These results support a "diffuse damage" hypothesis of aSAH, indicated by late phase phonemic fluency impairment. Overall, the phonemic and semantic tests represent a viable, rapid clinical screening tool in the postoperative assessment of patients with aSAH. PMID: 24803729 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Ladowski D, Qian W, Kapadia AN, Macdonald RL, Schweizer TA Tags: Behav Neurol Source Type: research

Deep Brain Stimulation in Persistent Vegetative States: Ethical Issues Governing Decision Making.
Abstract The aim of the present paper was to investigate the fundamental ethical issues of Deep Brain Stimulation (DBS) on patients remaining in Persistent Vegetative State (PVS). First, the purpose of this analysis was to discuss the nature of this intervention in order to classify it such as an ordinary clinical practice, or otherwise as an extraordinary clinical practice or as experimental research. Second, ethical issues, criticisms, and methodological issues of this intervention, also in the future perspectives, are discussed, attempting to identify who could give informed consent for a patient in PVS. P...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Patuzzo S, Manganotti P Tags: Behav Neurol Source Type: research

Fahr's Disease Presenting with Dementia at Onset: A Case Report and Literature Review.
We described a rare case of Fahr's disease presenting at onset only with behavioral and neuropsychological alterations, whose diagnosis was supposed only after a brain CT, which showed extensive bilateral calcifications in the dentate nuclei of the cerebellum and basal ganglia. Since the onset of Fahr's disease may be a dysexecutive syndrome with behavioral abnormalities, the clinical and radiological features are really important to do the appropriate diagnosis. PMID: 24803731 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Calabrò RS, Spadaro L, Marra A, Bramanti P Tags: Behav Neurol Source Type: research

Late Onset Bipolar Disorder due to a Lacunar State.
Conclusion. Our case sheds light on the role of the basal ganglia in mood disorders and the importance of ruling out brain injury in late onset BP. PMID: 24803732 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Antelmi E, Fabbri M, Cretella L, Guarino M, Stracciari A Tags: Behav Neurol Source Type: research

rTMS in the Treatment of Drug Addiction: An Update about Human Studies.
Abstract Drug addiction can be a devastating and chronic relapsing disorder with social, psychological, and physical consequences, and more effective treatment options are needed. Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive brain stimulation technique that has been assessed in a growing number of studies for its therapeutic potential in treating addiction. This review paper offers an overview on the current state of clinical research in treating drug addiction with rTMS. Because of the limited research in this area, all studies (including case reports) that evaluated the therapeutic use of...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Bellamoli E, Manganotti P, Schwartz RP, Rimondo C, Gomma M, Serpelloni G Tags: Behav Neurol Source Type: research

A case of gorlin-goltz syndrome presented with psychiatric features.
We report a case of a 34-year-old male who presented with an acute onset of pleomorphic psychiatric features. Upon examination we later diagnosed him with Gorlin-Goltz syndrome based on clinical and radiological findings that are characteristic for this rare autosomal dominant syndrome. His psychiatric manifestations included irritability, aggressive behavior, labile mood, hallucinations, paranoid delusions, and transient cognitive impairment. His past history indicated surgical excision of pigmented lesion in the left lower eyelid which turned out to be a basal cell carcinoma. His past visits to dermatology clinics indica...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Mufaddel A, Alsabousi M, Salih B, Alhassani G, Osman OT Tags: Behav Neurol Source Type: research

Anxiety changes depersonalization and derealization symptoms in vestibular patients.
Conclusion. Anxiety has an effect on depersonalization and derealization symptoms in vestibular patients. The various hypotheses about the underlying mechanism of this effect were discussed. PMID: 24803735 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Kolev OI, Georgieva-Zhostova SO, Berthoz A Tags: Behav Neurol Source Type: research

Intermittent alien hand syndrome and callosal apraxia in multiple sclerosis: implications for interhemispheric communication.
We report a case of a 47-year-old woman with 35-year history of multiple sclerosis, who showed alien hand signs, a rare behavioural disorder that involves unilateral goal-directed movements that are contrary to the individual's intention. Alien hand syndrome has been described in multiple sclerosis (MS) only occasionally and is generally suggestive of callosal disconnection. The patient presented also with bilateral limb apraxia and left hand agraphia, raising the possibility of cortical dysfunction or disconnection, in addition to corpus callosum and white matter involvement. Her specific pattern of symptoms supports the ...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Lunardelli A, Sartori A, Mengotti P, Rumiati RI, Pesavento V Tags: Behav Neurol Source Type: research

Vocabulary is an appropriate measure of premorbid intelligence in a sample with heterogeneous educational level in Brazil.
The objective was to compare performance in tests that measure crystallized and fluid intelligence in healthy subjects and patients with amnestic MCI (aMCI) and AD. One hundred forty-four participants (aMCI (n = 38), AD (n = 45), and healthy controls (n = 61)) were submitted to neuropsychological tests (WAIS-III vocabulary, BD, and RCM). There were significant among groups, except for vocabulary, indicating a relative stability of crystallized intelligence in the continuum from normal to pathological cognitive decline. Vocabulary seems to be stable during the progression of the disease and useful as a measure of premorbid ...
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: de Oliveira MO, Nitrini R, Yassuda MS, Brucki SM Tags: Behav Neurol Source Type: research

Effects of direction and index of difficulty on aiming movements after stroke.
Conclusion. Right and left hemisphere damages are differentially influenced by task constraints which suggest their complementary roles in the control of aiming movements. PMID: 24803738 [PubMed - in process] (Source: Behavioural Neurology)
Source: Behavioural Neurology - May 9, 2014 Category: Neurology Authors: Ribeiro Coqueiro P, de Freitas SM, Assunção E Silva CM, Alouche SR Tags: Behav Neurol Source Type: research

Textbook of Clinical Neuropsychiatry and Behavioral Neuroscience - third edition, by David P. Moore and Basant K. Puri, eds.
Authors: PMID: 24188985 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - October 31, 2013 Category: Neurology Tags: Behav Neurol Source Type: research

Verbal comprehension ability in aphasia: Demographic and lexical knowledge effects.
CONCLUSIONS: Indices of internal consistency and test-retest reliability were very good. Education and age effects on performance were significant, with the former being stronger. The potential clinical utility of differential ability indices (contrasting sentence- and word level-auditory comprehension tests) is discussed. PMID: 24188986 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - October 31, 2013 Category: Neurology Authors: Simos PG, Kasselimis D, Potagas C, Evdokimidis I Tags: Behav Neurol Source Type: research

Executive and language control in the multilingual brain.
We report a trilingual case of a Cantonese (L1), English (L2), and Mandarin (L3) speaker, Dr. T, who sustained a brain injury at the age of 77-years causing lesions in the left frontal lobe and in the left temporo-parietal areas resulting in fluent aphasia. Dr. T's executive functions were impaired according to a modified version of the Stroop color-word test and the Wisconsin Card Sorting Test performance was characterized by frequent perseveration errors. Dr. T demonstrated pathological language switching and mixing across her three languages. Code switching in Cantonese was more prominent in discourse production than co...
Source: Behavioural Neurology - September 27, 2013 Category: Neurology Authors: Kong AP, Abutalebi J, Lam KS, Weekes B Tags: Behav Neurol Source Type: research

Semantic dementia shows both storage and access disorders of semantic memory.
CONCLUSIONS: These results suggest that SD patients have both storage and access disorders, and have more severe access disorder than patients with AD. PMID: 24036967 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - September 12, 2013 Category: Neurology Authors: Takahashi Y, Meguro K, Nakatsuka M, Kasai M, Akanuma K, Yamaguchi S Tags: Behav Neurol Source Type: research

Fahr's disease presenting with dementia at onset: A case report and literature review.
We described a rare case of Fahr's disease presenting at onset only with behavioral and neuropsychological alterations, whose diagnosis was supposed only after a brain CT, which showed extensive bilateral calcifications in the dentate nuclei of the cerebellum and basal ganglia. Since the onset of Fahr's disease may be a dysexecutive syndrome with behavioral abnormalities, the clinical and radiological features are really important to do the appropriate diagnosis. PMID: 24036968 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - September 12, 2013 Category: Neurology Authors: Calabrò RS, Spadaro L, Marra A, Bramanti P Tags: Behav Neurol Source Type: research

Bipolar disorder and multiple sclerosis: A case series.
CONCLUSIONS: MRI lesions suggest the possible implication of local MS-related brain damage in development of pure "psychiatric fits" in MS. Genetic susceptibility is another hypothesis for this association. We have noticed that interferon beta treatments were well tolerated while high dose corticosteroids may induce manic fits. PMID: 24036969 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - September 12, 2013 Category: Neurology Authors: Sidhom Y, Djebara MB, Hizem Y, Abdelkefi I, Kacem I, Gargouri A, Gouider R Tags: Behav Neurol Source Type: research

Effect of age, education, and bilingualism on confrontation naming in older illiterate and low educated populations.
Abstract We investigated the effects of age as well as the linked factors of education and bilingualism on confrontation naming in rural Kashmir by creating a culturally appropriate naming test with pictures of 60 objects. We recruited 48 cognitively normal participants whose ages ranged from 18-28 and 60-85. Participants in our study were illiterate monolinguals (N=18) and educated Kashmiri-Urdu bilinguals (N=30). Hierarchical Multiple Regression revealed younger adults performed better than older adults (p
Source: Behavioural Neurology - September 12, 2013 Category: Neurology Authors: Ashaie S, Obler L Tags: Behav Neurol Source Type: research

Aphasia therapy in the age of globalisation: Cross-linguistic therapy effects in bilingual aphasia.
DISCUSSION: A number of factors that play a role on CLT of therapy effects are identified and discussed. Specifically, the evidence suggests that the word type the degree of structural overlap between languages, the type of therapy approach, the pre-and post morbid language proficiency profiles and the status of the cognitive control circuit play a role in the potential for CLT of therapy effects from the treated to the untreated language. PMID: 24036965 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - September 9, 2013 Category: Neurology Authors: Ansaldo AI, Saidi LG Tags: Behav Neurol Source Type: research

Dopamine treatment and cognitive functioning in individuals with Parkinson's disease. The "cognitive flexibility" hypothesis seems to work.
Dopamine treatment and cognitive functioning in individuals with Parkinson's disease. The "cognitive flexibility" hypothesis seems to work. Behav Neurol. 2013 Sep 9; Authors: Costa A, Peppe A, Mazzu I, Longarzo MC, Caltagirone C, Carlesimo GA Abstract BACKGROUND: previous data suggest that i) dopamine modulates the ability to implement non-routine schemata and updating operations (flexibility processes) and that ii) dopamine-related improvement may be related to baseline dopamine levels in target pathways (inverted U-shaped hypothesis). OBJECTIVE: to investigate above hypotheses in individua...
Source: Behavioural Neurology - September 9, 2013 Category: Neurology Authors: Costa A, Peppe A, Mazzu I, Longarzo MC, Caltagirone C, Carlesimo GA Tags: Behav Neurol Source Type: research

Regional MRI perfusion measures predict motor/executive function in patients with Clinically Isolated Syndrome.
CONCLUSION: Impaired executive function in CIS patients correlated positively with elevated regional CBV values thought to reflect inflammatory processes. PMID: 23963238 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Papadaki EZ, Simos PG, Mastorodemos VC, Panou T, Maris TG, Karantanas AH, Plaitakis A Tags: Behav Neurol Source Type: research

A case of Gorling-Goltz syndrome presented with psychiatric features.
We report on a case of 34 Y.O. male who presented with an acute onset of pleomorphic psychiatric features. Upon examination we later diagnosed him with Gorlin-Goltz syndrome based on clinical and radiological findings that are characteristic for this rare autosomal dominant syndrome. The diagnosis of this syndrome is made by presence of two major criteria or one major and two minor criteria. Our patient manifested several of its characteristic multiple clinical features involving the skin, nervous system, eyes, endocrine system and bones. His psychiatric manifestations included irritability, aggressive behavior, labile moo...
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Mufaddel A, Alsabousi M, Salih B, Alhassani G, Osman OT Tags: Behav Neurol Source Type: research

Cavernous angioma of the corpus callosum presenting with acute psychosis.
We present a case of a sudden psychotic attack presumably due to a hemorrhagic cavernous angioma of the corpus callosum, which was surgically removed with complete resolution of symptoms. Although a developmental defect like agenesis or lipoma is present in the majority of these cases, a growing lesion of the corpus callosum can rarely be the primary cause. Since it is potentially possible to cure these patients, clinicians should be aware of this association. PMID: 23963240 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Pavesi G, Causin F, Feletti A Tags: Behav Neurol Source Type: research

Late onset bipolar disorder due to a lacunar state.
CONCLUSION: Our case sheds light on the role of the basal ganglia in mood disorders and the importance of ruling out brain injury in late onset BD. PMID: 23963241 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Antelmi E, Fabbri M, Cretella L, Guarino M, Stracciari A Tags: Behav Neurol Source Type: research

Why are different the right and left hemisphere conceptual representations?
Abstract The present survey develops a previous position paper, in which I suggested that the multimodal semantic impairment observed in advanced stages of Semantic Dementia are due to the joint disruption of pictorial and verbal representations, subtended by the right and left anterior temporal lobes, rather than to the loss of a unitary, amodal semantic system. The main goals of the present review are: (a) to survey a larger set of data, in order to confirm the differences in conceptual representations at the level of the right and left hemispheres; (b) to examine if language-mediated information plays a greater...
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Gainotti G Tags: Behav Neurol Source Type: research

Neurobiological abnormalities in the first few years of life in individuals later diagnosed with Autistic Spectrum Disorder: A review of recent data.
CONCLUSIONS: The studies across these different areas reveal the existence of atypicalities in the first year of life, well before ASD is reliably diagnosed. Cross-disciplinary approaches are essential to elucidate the pathophysiological sequence of events that lead to ASD. PMID: 23963243 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - August 20, 2013 Category: Neurology Authors: Allely CS, Gillberg C, Wilson P Tags: Behav Neurol Source Type: research

`The mind is its own place': Amelioration of claustrophobia in semantic dementia.
Abstract Phobias are among the few intensely fearful experiences we regularly have in our everyday lives, yet the brain basis of phobic responses remains incompletely understood. Here we describe the case of a 71 year old patient with a typical clinico-anatomical syndrome of semantic dementia led by selective (predominantly right-sided) temporal lobe atrophy, who showed striking amelioration of previously disabling claustrophobia following onset of her cognitive syndrome. We interpret our patient's newfound fearlessness as an interaction of damaged limbic and autonomic responsivity with loss of the cognitive meani...
Source: Behavioural Neurology - July 25, 2013 Category: Neurology Authors: Clark CN, Downey LE, Golden HL, Fletcher PD, de Silva R, Cifelli A, Warren JD Tags: Behav Neurol Source Type: research

rTMS in the treatment of drug addiction: An update about human studies.
Abstract Drug addiction can be a devastating and chronic relapsing disorder with social, psychological and physical consequences, and more effective treatment options are needed. Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation technique that has been assessed in a growing number of studies for its therapeutic potential in treating addiction. This review paper offers an overview on the current state of clinical research in treating drug addiction with rTMS. Because of the limited research in this area, all studies (including case reports) that evaluated the therapeutic use of...
Source: Behavioural Neurology - July 3, 2013 Category: Neurology Authors: Bellamoli E, Manganotti P, Schwartz RP, Rimondo C, Gomma M, Serpelloni G Tags: Behav Neurol Source Type: research

Delayed-onset post-stroke delusional disorder: A case report.
In this report, we describe delayed-onset post-stroke delusional disorder, persecutory type. A middle-aged female patient developed a persistent delusional disorder with homicidal behavior about one year after a cerebrovascular accident affecting the right fronto-temporo-parietal region and a long period of chronic post-stroke mixed anxiety and depressive symptoms. Our case suggests that there might be long intervals between stroke and the appearance of psychotic symptoms. PMID: 23619082 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - April 25, 2013 Category: Neurology Authors: Barboza RB, De Freitas GR, Tovar-Moll F, Fontenelle LF Tags: Behav Neurol Source Type: research

A case of REM sleep behavior disorder, narcolepsy-cataplexy, parkinsonism and rheumatoid arthritis.
Abstract A patient is reported in whom signs and symptoms of REM sleep behavior disorder (RBD) and narcolepsy have been associated for almost two decades with a late development of parkinsonism and rheumatoid arthritis. A 78-year-old male patient in whom RBD was first diagnosed was followed-up by clinical examination, videopolysomnography, multiple sleep latency test, cerebral magnetic resonance imaging, and dopamine transporter imaging by single-photon emission computerized tomography. The patient was found to present for almost two decades, in addition to RBD, also narcolepsy. Moreover, a late development of par...
Source: Behavioural Neurology - April 25, 2013 Category: Neurology Authors: Cosentino FI, Distefano A, Plazzi G, Schenck CH, Ferri R Tags: Behav Neurol Source Type: research

Optic neuritis: From magnocellular to cognitive residual dysfunction.
Abstract Optic Neuritis (ON) has been associated to both parvocellular dysfunction and to an alteration of the magnocellular pathway. After objective visual field and acuity recovery, ON patients may complain about their vision suggesting a residual subclinical deficit. To better characterize visual abnormalities, 8 patients recovering from a first ON episode as well as 16 healthy controls performed a simple detection task and a more complex categorization task of images presented in low spatial frequencies (to target the magnocellular system) or in high spatial frequencies (to target the parvocellular system) or ...
Source: Behavioural Neurology - April 25, 2013 Category: Neurology Authors: Viret AC, Cavezian C, Coubard O, Vasseur V, Raz N, Levin N, Vignal C, Gout O, Chokron S Tags: Behav Neurol Source Type: research

Methodological considerations in conducting an olfactory fMRI study.
Abstract The sense of smell is a complex chemosensory processing in human and animals that allows them to connect with the environment as one of their chief sensory systems. In the field of functional brain imaging, many studies have focused on locating brain regions that are involved during olfactory processing. Despite wealth of literature about brain network in different olfactory tasks, there is a paucity of data regarding task design. Moreover, considering importance of olfactory tasks for patients with variety of neurological diseases, special contemplations should be addressed for patients. In this article,...
Source: Behavioural Neurology - April 25, 2013 Category: Neurology Authors: Vedaei F, Fakhri M, Harirchian MH, Firouznia K, Ali Oghabian M Tags: Behav Neurol Source Type: research

Delusion of pregnancy: A case revisited.
Abstract A patient with delusion of pregnancy as an early feature of frontotemporal dementia with motor neurone disease (FTD/MND) who was reported some years ago was posthumously found to harbor the C9ORF72 hexanucleotide repeat expansion, now known to be the most common genetic cause of FTD/MND. Some series have found psychosis to be common in FTD associated with this mutation, so this test should be considered in individuals with clinical features of FTD and MND and/or with a family history of either disorder who present with bizarre delusions. PMID: 23548882 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - April 2, 2013 Category: Neurology Authors: Larner AJ Tags: Behav Neurol Source Type: research

Topiramate for abnormal eating behaviour in frontotemporal dementia.
This report describes a man with frontotemporal dementia, behavioural variant, associated with abnormal eating behaviour which appeared to respond to topiramate. We review the physiological basis of abnormal eating behaviour in frontotemporal dementia and explore possible mechanisms of action by which topiramate may modify eating behaviour in this condition. PMID: 23548883 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - April 2, 2013 Category: Neurology Authors: Singam C, Walterfang M, Mocellin R, Evans A, Velakoulis D Tags: Behav Neurol Source Type: research

Patterns of cognitive dysfunction in progressive MS.
CONCLUSIONS: In addition to a prominent global influence on cognitive performance, patients with progressive MS commonly exhibit language and visuospatial deficits. Evaluation of these abilities should therefore be included in clinical assessment of cognition in progressive MS. PMID: 23548884 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - April 2, 2013 Category: Neurology Authors: Connick P, Chandran S, Bak TH Tags: Behav Neurol Source Type: research

Change of accent as an atypical onset of non fluent primary progressive aphasia.
We describe the case of a woman presenting a progressive isolated language disturbance, characterized by an early dysprosodia, phonological and semantic paraphasias, agrammatism,. impairment in repetition, writing of non-words and sentence comprehension. This clinical picture pointed to an atypical presentation of the non-fluent variety. The frequent symptom overlap between the different variants of PPA, most likely reflecting differences in the topography of the pathological changes, needs to be considered in the definition of diagnostic criteria. PMID: 23396217 [PubMed - as supplied by publisher] (Source: Behavioural Neurology)
Source: Behavioural Neurology - February 8, 2013 Category: Neurology Authors: Paolini S, Paciaroni L, Manca A, Rossi R, Fornarelli D, Cappa SF, Abbatecola AM, Scarpino O Tags: Behav Neurol Source Type: research

The qualitative scoring MMSE pentagon test (QSPT): A new method for differentiating dementia with Lewy Body from Alzheimer's disease.
This study aimed to validate a qualitative scoring method for the pentagons copy test (QSPT) of Mini-Mental State Examination (MMSE) based on the assessment of different parameters of the pentagons drawing, such as number of angles, distance/intersection, closure/opening, rotation, closing-in, and to verify its efficacy to differentiate dementia with Lewy Body (DLB) from Alzheimer's disease (AD). We established the reliability of the qualitative scoring method through the inter-raters and intra-subjects analysis. QSPT was then applied to forty-six AD and forty-six DLB patients, using two phases statistical approach, standa...
Source: Behavioural Neurology - February 8, 2013 Category: Neurology Authors: Caffarra P, Gardini S, Dieci F, Copelli S, Maset L, Farina E, Grossi E Tags: Behav Neurol Source Type: research

Possible roles of the dominant uncinate fasciculus in naming objects: A case report of intraoperative electrical stimulation on a patient with a brain tumour.
Abstract How the dominant uncinate fasciculus (UF) contributes to naming performance is uncertain. In this case report, a patient with an astrocytoma near the dominant UF was given a picture-naming task during intraoperative electrical stimulation in order to resect as much tumourous tissues as possible without impairing the dominant UF function. Here we report that the stimulations with the picture-naming task also provided some insights into how the dominant UF contributes to naming performance. The stimulation induced naming difficulty, verbal paraphasia, and recurrent and continuous perseveration. Moreover, ju...
Source: Behavioural Neurology - December 14, 2012 Category: Neurology Authors: Nomura K, Kazui H, Tokunaga H, Hirata M, Goto T, Goto Y, Hashimoto N, Yoshimine T, Takeda M Tags: Behav Neurol Source Type: research