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Condition: Brain Tumor
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Total 810 results found since Jan 2013.
MicroRNA-29a-3p Downregulation Causes Gab1 Upregulation to Promote Glioma Cell Proliferation
Conclusions: miR-29a-3p downregulation leads to Gab1 upregulation to promote glioma cell proliferation.Cell Physiol Biochem 2018;48:450 –460
Source: Cellular Physiology and Biochemistry - July 17, 2018 Category: Cytology Source Type: research
c-Fos/microRNA-18a feedback loop modulates the tumor growth via HMBOX1 in human gliomas
In conclusion, our study determine that c-Fos/miR-18a feedback loop promotes the tumor growth of gliomas by HMBOX1, providing important clues for understanding the key roles of transcription factor mediated mRNA-miRNA functional network in the regulation of gliomas.Graphical abstract
Source: Biomedicine and Pharmacotherapy - September 19, 2018 Category: Drugs & Pharmacology Source Type: research
Ubiquitin-specific protease 22 promotes the proliferation, migration and invasion of glioma cells.
Abstract
Ubiquitin-specific protease 22 (USP22), as one of the 11 death-from-cancer signature genes, presented high expression in a variety of tumors. Previous studies showed that USP22 played a significant role in cell-cycle, oncogenesis, clinicopathology and survival. Our studies have presented USP22 was over-expressed in glioma tissue and the patients with high expression of USP22 had a poor survival than that with low expression of USP22. However, the concrete effect of USP22 on biological behavior in glioma cells has been rarely reported. The study aimed to clear the effect of USP22 on cell proliferation, mi...
Source: Cancer Biomarkers : Section A of Disease Markers - September 3, 2018 Category: Cancer & Oncology Authors: Liang J, Zhang XL, Li S, Xie S, Wang WF, Yu RT Tags: Cancer Biomark Source Type: research
miR-126 Suppresses Invasion and Migration of Malignant Glioma by Targeting Mature T Cell Proliferation 1 (MTCP1).
CONCLUSIONS miR-126 inhibits the migration of malignant glioma cells by inhibiting MTCP1.
PMID: 30233082 [PubMed - in process]
Source: Medical Science Monitor - September 22, 2018 Category: Research Tags: Med Sci Monit Source Type: research
Comparative proteomic analysis of cat eye syndrome critical region protein 1- function in tumor-associated macrophages and immune response regulation of glial tumors.
Conclusion: This study reports the molecular pathways and key molecules that are mediated by CECR1 function in THP- 1-derived MQs and TAMs in glioma.
Methods: PMA-treated THP-1 cells (MQs) were siRNA transfected for CECR1 in vitro, with or without stimulation of the primary glioma cell line U87. Lysates were analyzed by (nano)LC-MS. Significant altered protein levels were identified (P < 0.05), followed by pathway annotation.
PMID: 30323894 [PubMed]
Source: Oncotarget - October 17, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Cell Division Cycle Associated 7 Like Predicts Unfavorable Prognosis and Promotes Invasion in Glioma
ConclusionsCDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients.
Source: Pathology Research and Practice - October 24, 2018 Category: Pathology Source Type: research
Cell division cycle associated 7 like predicts unfavorable prognosis and promotes invasion in glioma.
CONCLUSIONS: CDCA7L is highly expressed in human glioma tissues and a high CDCA7L expression level predicts the dismal prognosis for glioma patients. Moreover, CDCA7L can promote glioma invasion, which can serve as an independent potential prognostic biomarker for glioma patients.
PMID: 30389317 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - October 24, 2018 Category: Pathology Authors: Shen FZ, Li XS, Ma JW, Wang XY, Zhao SP, Meng L, Liang SF, Zhao XL Tags: Pathol Res Pract Source Type: research
Long Noncoding RNA OIP5-AS1 targets Wnt-7b to affect glioma progression via modulation of miR-410.
This study was undertaken to investigate the underlying mechanisms of long noncoding RNA OIP5-AS1 via regulating miR-410 to modulate Wnt-7b in the progression of glioma. To address this problem, we measured the expression of OIP5-AS1 and miR-410 in glioma tissues by qRT-PCR. Glioma U87 cells were transfected with OIP5-AS1 siRNA or miR-410 inhibitors. The targeting relationships among miR-410, OIP5-AS1 and Wnt-7b were verified by luciferase reporter assays. Western blotting was employed to determine the expression of Wnt-7b/β-catenin pathway-related proteins, while MTT, flow cytometry, Transwell assays, and wound-healing a...
Source: Bioscience Reports - November 29, 2018 Category: Biomedical Science Authors: Sun WL, Kang T, Wang YY, Sun JP, Li C, Liu HJ, Yang Y, Jiao BH Tags: Biosci Rep Source Type: research
Cancers, Vol. 11, Pages 406: Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness
Catherine SEVA
Glioblastoma (GBM) is the most lethal primary brain tumor in adults and is known to be particularly aggressive and resistant to anti-cancer therapies, mainly due to the presence of GBM stem cells (GBMSC). By in vitro approaches supported by analysis from patients&rsquo; databases, we determined how &alpha;6-integrin and Fibroblast Growth Factor Receptor 1 (FGFR1) work in concert to regulate proliferation and stemness of GBMSC. We showed that &alpha;6-integrin regulates the expression of FGFR1 and its target gene Fokhead Box M1 (FOXM1) via the ZEB1/YAP1 transcription complex. Thes...
Source: Cancers - March 21, 2019 Category: Cancer & Oncology Authors: Aline KOWALSKI-CHAUVEL Valerie GOUAZE-ANDERSSON Laurent BARICAULT Elodie MARTIN Caroline DELMAS Christine TOULAS Elizabeth COHEN-JONATHAN-MOYAL Catherine SEVA Tags: Article Source Type: research
High Expression of DEPDC1 Promotes Malignant Phenotypes of Breast Cancer Cells and Predicts Poor Prognosis in Patients With Breast Cancer
In this study, the immunohistochemistry results demonstrated that DEPDC1 was high-expressed in breast cancer tissues compared with the paired adjacent normal breast tissues, and its tendency at protein level was consistent with mRNA level from TCGA data. Moreover, DEPDC1 mRNA level revealed the strongest association with poor prognosis and development in breast cancer. In vitro assays showed that DEPDC1 overexpression resulted in significant promotion of proliferation by regulating cell cycle in MCF-7 cells, whilst an opposite effect was found in the MDA-MB-231 cells with DEPDC1 deletion. Notably, further investigation ind...
Source: Frontiers in Oncology - April 11, 2019 Category: Cancer & Oncology Source Type: research
Celastrol enhances TRAIL-induced apoptosis in human glioblastoma via the death receptor pathway
ConclusionsTaken together, the results of our study demonstrate that celastrol sensitizes glioma cells to TRAIL via the death receptor pathway and that DR5 plays an important role in the effects of this cotreatment. The results indicate that this cotreatment is a promising tumor-killing therapeutic strategy with high efficacy and low toxicity.
Source: Cancer Chemotherapy and Pharmacology - July 7, 2019 Category: Cancer & Oncology Source Type: research
Tim-3 expression in glioma cells is associated with drug resistance
Conclusions: The presence of Tim-3 mRNA and protein in glioma cells was detected. Significantly, knocking down Tim-3 expression improved the potential of TMZ treatment.
Source: Journal of Cancer Research and Therapeutics - August 13, 2019 Category: Cancer & Oncology Authors: Ji Zhang Zheng Quan Zhu Yan Xia Li Qiu Feng Zhuang Yuanhong Lai Shao Fang Li Xiao Bing Xu Jian Min Liu Source Type: research
LINK-A lncRNA participates in the pathogenesis of glioma by interacting with survivin.
In conclusion, LINK-A lncRNA inhibited glioma cell apoptosis potentially by the upregulation of survivin. The present study revealed that LINK-A may serve as possible diagnostic marker for glioma.
PMID: 31410112 [PubMed]
Source: Experimental and Therapeutic Medicine - August 16, 2019 Category: General Medicine Tags: Exp Ther Med Source Type: research
Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis
ConclusionElevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
Source: Pathology Research and Practice - December 18, 2019 Category: Pathology Source Type: research
Adipocyte enhancer binding protein 1 (AEBP1) knockdown suppresses human glioma cell proliferation, invasion and induces early apoptosis.
CONCLUSION: Elevated AEBP1 is positively associated with poor prognosis of glioma. AEBP1 downregulation suppressed cell proliferation and invasion, but promoted early cell apoptosis. AEBP1 downregulation suppressed the cell proliferation and invasion may by inhibiting the NF-κB signaling pathway.
PMID: 31864713 [PubMed - as supplied by publisher]
Source: Pathology, Research and Practice - December 16, 2019 Category: Pathology Authors: Cheng L, Shao X, Wang Q, Jiang X, Dai Y, Chen S Tags: Pathol Res Pract Source Type: research
