Filtered By:
Condition: Brain Tumor

This page shows you your search results in order of relevance. This is page number 6.

Order by Relevance | Date

Total 810 results found since Jan 2013.

The combination of baicalin with knockdown of miR148a gene suppresses cell viability and proliferation and induces the apoptosis and autophagy of human glioblastoma multiforme T98G and U87MG cells
CONCLUSION: The siRNA-induced miR148a mRNA knockdown in combination with baicalin may offer a novel therapeutic strategy to more effective control the growth of human GBM cells. Thus, knockdown of this gene in combination with baicalin inhibits proliferation (cell cycle arrest in S phase in T98G but not in U87MG cells), induces apoptosis and regulates autophagy in T98G and U87MG cells, but further studies urgently needed to confirm a positive phenomenon for the treatment of GBM.PMID:35761505 | DOI:10.2174/1389201023666220627144100
Source: Current Pharmaceutical Biotechnology - June 28, 2022 Category: Biotechnology Authors: Monika Paul-Samojedny Emilia Liduk Ma łgorzata Kowalczyk Paulina Borkowska Aleksandra Zieli ńska Renata Suchanek-Raif Jan Kowalski Source Type: research

Osteopontin and splice variant expression level in human malignant glioma: Radiobiologic effects and prognosis after radiotherapy
Conclusions: OPNb is partially able to compensate the effects of OPNa and OPNc knockdown in U251MG cells. High OPN plasma levels at the end of radiotherapy are associated with poor survival.
Source: Radiotherapy and Oncology - July 29, 2013 Category: Radiology Authors: Antje Güttler, Maria Giebler, Peter Cuno, Henri Wichmann, Jacqueline Keßler, Christian Ostheimer, Ariane Söling, Christian Strauss, Jörg Illert, Matthias Kappler, Dirk Vordermark, Matthias Bache Tags: Original Articles Source Type: research

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration
Conclusion: Together, our data show a novel role for the WNK1/OSR1/NKCC1 pathway in basal and TMZ-induced glioma migration, and suggest that glioma treatment with TMZ might be improved by drugs that inhibit elements of the WNK1/OSR1/NKCC1 signaling pathway.
Source: Molecular Cancer - February 20, 2014 Category: Cancer & Oncology Authors: Wen ZhuGulnaz BegumKelli PointerPaul ClarkSung-Sen YangShih-Hua LinKristopher KahleJohn KuoDandan Sun Source Type: research

GSCs Are TLR9+ and Inhibited by CpG-STAT3siRNA
Understanding supports for cancer stem–like cells in malignant glioma may suggest therapeutic strategies for their elimination. Here, we show that the Toll-like receptor TLR9 is elevated in glioma stem–like cells (GSC) in which it contributes to glioma growth. TLR9 overexpression is regulated by STAT3, which is required for GSC maintenance. Stimulation of TLR9 with a CpG ligand (CpG ODN) promoted GSC growth, whereas silencing TLR9 expression abrogated GSC development. CpG-ODN treatment induced Frizzled4-dependent activation of JAK2, thereby activating STAT3. Targeted delivery of siRNA into GSC was achieved via TLR9 usi...
Source: Cancer Research - September 14, 2014 Category: Cancer & Oncology Authors: Herrmann, A., Cherryholmes, G., Schroeder, A., Phallen, J., Alizadeh, D., Xin, H., Wang, T., Lee, H., Lahtz, C., Swiderski, P., Armstrong, B., Kowolik, C., Gallia, G. L., Lim, M., Brown, C., Badie, B., Forman, S., Kortylewski, M., Jove, R., Yu, H. Tags: Therapeutics, Targets, and Chemical Biology Source Type: research

PCI-24781 down-regulates EZH2 expression and then promotes glioma apoptosis by suppressing the PIK3K/Akt/mTOR pathway
PCI-24781 is a novel histone deacetylase inhibitor that inhibits tumor proliferation and promotes cell apoptosis. However, it is unclear whether PCI-24781 inhibits Enhancer of Zeste 2 (EZH2) expression in malignant gliomas. In this work, three glioma cell lines were incubated with various concentrations of PCI-24781 (0, 0.25, 0.5, 1, 2.5 and 5 M) and analyzed for cell proliferation by the MTS 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium assay and colony formation, and cell cycle and apoptosis were assessed by flow cytometry. The expression of EZH2 and apoptosis-related proteins w...
Source: Genetics and Molecular Biology - December 11, 2014 Category: Genetics & Stem Cells Source Type: research

Abstract 44: EGFR and Dock180 activate MLK3 to drive invasion of glioblastoma cells
Glioblastoma (GBM) is the most common and deadly form of brain tumor in adults, with an average post-diagnosis survival time of 15 months. While GBMs rarely metastasize to distant organs, they readily invade into surrounding brain tissue, leading to incomplete surgical resection and subsequent tumor recurrence. Epidermal Growth Factor Receptor (EGFR) signaling is aberrantly activated in a majority of GBM tumors, and is clearly implicated in multiple malignant phenotypes, including migration and invasion. However, direct targeting of EGFR has been largely unsuccessful, for multiple reasons, including compensatory upregulati...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Misek, S. A., Chen, J., Gallo, K. A. Tags: Molecular and Cellular Biology Source Type: research

Down-regulation of anti-apoptotic genes in tumor cell lines is facilitated by suppression of OCT4B1
Conclusions It may possibly be concluded that suppression of OCT4B1 can lead to apoptosis in tumor cell lines and this is at least facilitated via down-regulation of examined anti-apoptotic genes. Accordingly, suppression of OCT4B1 may probably be considered as useful tool in cancer therapy and research.
Source: Advances in Medical Sciences - May 10, 2016 Category: Biomedical Science Source Type: research

Effects of caffeine on cell viability and activity of histone deacetylase 1 and histone acetyltransferase in glioma cells
Conclusion Our data suggest that a new strategy, caffeine, could increase glioma cell death by decreasing HDAC1 activity and/or by increasing p300 activity. The changes in HDAC1 and p300 activities appeared to occur earlier than loss of RT2 cells.
Source: Tzu Chi Medical Journal - August 2, 2016 Category: Universities & Medical Training Source Type: research