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Condition: Brain Tumor

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Total 810 results found since Jan 2013.

Leucine-rich glioma inactivated 3 associates negatively with adiponectin.
Abstract Leucine-rich glioma inactivated 3 (LGI3) is a secreted protein member of LGI/epitempin family. We previously reported that LGI3 was expressed in adipose tissues and suppressed adipogenesis through its receptor, ADAM23. We proposed that LGI3 may be a candidate adipokine with pro-inflammatory activity. To investigate the role of LGI3 in adipose tissues, we analyzed cytokine profile in LGI3 knockout mice. Protein array analysis showed that adiponectin was significantly increased in adipose tissues and plasma of LGI3 knockout mice. SiRNA-mediated knockdown of LGI3 increased adiponectin in 3T3-L1 preadipocytes...
Source: Cytokine - May 1, 2013 Category: Molecular Biology Authors: Kim HA, Kwon NS, Baek KJ, Kim DS, Yun HY Tags: Cytokine Source Type: research

The roles of Notch1 expression in the migration of intrahepatic cholangiocarcinoma
Conclusion: Notch1 may induce a migratory effect in ICC by causing an epithelial-mesenchymal transition and activating Rac1 and could serve as a novel diagnostic and therapeutic target in patients with ICC.
Source: BMC Cancer - May 20, 2013 Category: Cancer & Oncology Authors: Qi ZhouYafeng WangBaogang PengLijian LiangJiaping Li Source Type: research

Glioma pathogenesis-related protein 1 induces prostate cancer cell death through Hsc70-mediated suppression of AURKA and TPX2
In this study we report that expression of glioma pathogenesis-related protein 1 (GLIPR1) regulated numerous apoptotic, cell cycle, and spindle/centrosome assembly-related genes, including AURKA and TPX2, and induced apoptosis and/or mitotic catastrophe (MC) in prostate cancer (PCa) cells, including p53-mutated/deleted, androgen-insensitive metastatic PCa cells. Mechanistically, GLIPR1 interacts with heat shock cognate protein 70 (Hsc70); this interaction is associated with SP1 and c-Myb destabilization and suppression of SP1- and c-Myb-mediated AURKA and TPX2 transcription. Inhibition of AURKA and TPX2 using siRNA mimicke...
Source: Molecular Oncology - January 7, 2013 Category: Cancer & Oncology Authors: Likun Li, Guang Yang, Chengzhen Ren, Ryuta Tanimoto, Takahiro Hirayama, Jianxiang Wang, David Hawke, Soo Mi Kim, Ju-Seog Lee, Alexei A. Goltsov, Sanghee Park, Michael M. Ittmann, Patricia Troncoso, Timothy C. Thompson Tags: Papers Source Type: research

MicroRNA-222 promotes tumorigenesis via targeting DKK2 and activating the Wnt/β-catenin signaling pathway
Highlights: Abstract: MiR-222 in glioma can regulate cell cycle progression and apoptosis. However, the relationship between miR-222 and Wnt/β-catenin signaling pathway in glioma remains unknown. Here, we found that the Dickkopf-2 gene (DKK2) was a direct target of miR-222 by target prediction analysis and dual luciferase reporter assay. RNA interference silencing of DKK2 proved that miR-222 overexpression led to constitutive activation of β-catenin through inhibition of DKK2 expression in glioma cells. Furthermore, miR-222 siRNA significantly inhibited tumorigenesis in vivo. Finally, Western blot analysis showed that mi...
Source: FEBS Letters - April 15, 2013 Category: Biochemistry Authors: Qifeng Li, Ke Shen, Yang Zhao, Xiaoguang He, Chenkai Ma, Lin Wang, Baocheng Wang, Jianwen Liu, Jie Ma Tags: Research Letters Source Type: research

Salvianolic Acid B Induces Apoptosis in Human Glioma U87 Cells Through p38-Mediated ROS Generation.
Abstract Salvianolic acid B (SalB), the main water-soluble bioactive compounds isolated from the traditional Chinese medical herb Danshen, has been shown to exert anti-cancer effect in several cancer cell lines. The aim of our study was to investigate the potential anti-cancer effect of SalB in human glioma U87 cells. We found that treatment with SalB significantly decreased cell viability of U87 cells in a dose- and time-dependent manner. SalB also enhanced the intracellular ROS generation and induced apoptotic cell death in U87 cells. Western blot analysis suggested that SalB increased the phosphorylation of p38...
Source: Cellular and Molecular Neurobiology - July 11, 2013 Category: Cytology Authors: Wang ZS, Luo P, Dai SH, Liu ZB, Zheng XR, Chen T Tags: Cell Mol Neurobiol Source Type: research

Role of moesin in hyaluronan induced cell migration in glioblastoma multiforme
Conclusions: Our results suggest that development of inhibitors which interfere with CD44-moesin interactions may open a new avenue in the future to mitigate cellular migration in gliomas.
Source: Molecular Cancer - July 15, 2013 Category: Cancer & Oncology Authors: Leroi DeSouzaAjay MattaZia KarimJoydeep MukherjeeX WangOlga KrakovskaGelareh ZadehAbhijit GuhaKW Siu Source Type: research

Cadmium induces N-cadherin cleavage via ERK-mediated γ-secretase activation in C6 astroglia cells.
Abstract N-cadherin has known to be involved in tumor progression and metastasis. However, it is still obscure about the signaling pathway involving in the processing of N-cadherin. Thus, we examined which signaling pathway plays a major role in the processing of N-cadherin in C6 glioma cells following treatment of Cadmium (Cd), a highly ubiquitous heavy metal. A cleavage product of N-cadherin, N-cad/CTF2 was observed by the treatment of Cd to C6 cells in a time and concentration-dependent manner. The production of N-cad/CTF2 was inhibited by pretreatment of γ-secretase inhibitors or siRNA transfection of nicastr...
Source: Toxicology Letters - July 19, 2013 Category: Toxicology Authors: Jo C, Koh YH Tags: Toxicol Lett Source Type: research

SGEF Promotes Fn14-induced GB Invasion Cell Biology
Glioblastoma (GB) is the highest grade of primary adult brain tumors, characterized by a poorly defined and highly invasive cell population. Importantly, these invading cells are attributed with having a decreased sensitivity to radiation and chemotherapy. TNF-like weak inducer of apoptosis (TWEAK)-Fn14 ligand-receptor signaling is one mechanism in GB that promotes cell invasiveness and survival and is dependent upon the activity of multiple Rho GTPases, including Rac1. Here we report that Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF), a RhoG-specific guanine nucleotide exchange factor, is over...
Source: Journal of Biological Chemistry - July 26, 2013 Category: Chemistry Authors: Fortin Ensign, S. P., Mathews, I. T., Eschbacher, J. M., Loftus, J. C., Symons, M. H., Tran, N. L. Tags: Cell Biology Source Type: research

Inhibition of polo-like kinase 1 in glioblastoma multiforme induces mitotic catastrophe and enhances radiosensitisation
This study suggests that PLK1 is an important therapeutic target for GBM and can enhance radiosensitivity in GBM.
Source: European Journal of Cancer - June 19, 2013 Category: Cancer & Oncology Authors: Anita T. Tandle, Tamalee Kramp, Whoon J. Kil, Aditya Halthore, Kristen Gehlhaus, Uma Shankavaram, Philip J. Tofilon, Natasha J. Caplen, Kevin Camphausen Tags: Neuro-oncology Source Type: research

Targeting Protein Kinase CK2 Suppresses Pro-survival Signaling Pathways and Growth of Glioblastoma.
CONCLUSIONS: CK2 inhibitors may be considered for treatment of patients with GBM. PMID: 24036851 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 13, 2013 Category: Cancer & Oncology Authors: Zheng Y, McFarland BC, Drygin D, Yu H, Bellis SL, Kim H, Bredel M, Benveniste EN Tags: Clin Cancer Res Source Type: research

YB-1 dependent oncolytic adenovirus efficiently inhibits tumor growth of glioma cancer stem like cells
Conclusion: The results of this study supported YB-1 based virotherapy as an attractive therapeutic strategy for GBM treatment which will be exploited further in multimodal treatment concepts.
Source: Journal of Translational Medicine - September 18, 2013 Category: Research Authors: Klaus MantwillUlrike NaumannJanina SeznecVroni GirbingerHermann LagePawel SurowiakDagmar BeierMichel MittelbronnJürgen SchlegelPer Holm Source Type: research

Metastatic prostate cancer cell-specific phage-like particles as a targeted gene-delivery system
Conclusion: Successful employment of phage-like particles expressing emerald green fluorescent protein genes targeted to prostate cancer cells PC-3M confirms a prospect of their use for targeted delivery of therapeutic genes to cancer cells.
Source: Journal of Nanobiotechnology - September 23, 2013 Category: Nanotechnology Authors: Olusegun FagbohunRobert KazmierczakValery PetrenkoAbraham Eisenstark Source Type: research

Human umbilical cord mesenchymal stem cells inhibit C6 glioma growth via secretion of dickkopf-1 (DKK1).
Abstract Mesenchymal stem cells (MSCs) represent a potential therapeutic target for glioma. We determined the molecular mechanism of inhibitory effect of human umbilical cord-derived MSCs (hUC-MSCs) on the growth of C6 glioma cells. We demonstrated that hUC-MSCs inhibited C6 cell growth and modulated the cell cycle to G0/G1 phase. The expression of β-catenin and c-Myc was downregulated in C6 cells by conditioned media from hUC-MSCs, and the levels of secreted DKK1 were positively correlated with concentrations of hUCMSCs-CM. The inhibitory effect of hUC-MSCs on C6 cell proliferation was enhanced as the concentrat...
Source: Molecular and Cellular Biochemistry - October 9, 2013 Category: Biochemistry Authors: Ma S, Liang S, Jiao H, Chi L, Shi X, Tian Y, Yang B, Guan F Tags: Mol Cell Biochem Source Type: research

Inhibition of autophagy enhances apoptosis induced by proteasome inhibitor bortezomib in human glioblastoma U87 and U251 cells.
Abstract Glioblastoma is the most aggressive cerebral gliomas. Despite advances in therapies, the prognosis is still very poor. Therefore, novel therapeutic strategies are required. As a proteasome inhibitor, bortezomib has shown its efficacy as an active antitumor agent against a variety of tumors. However, inhibition of proteasome activity leads to cell death and also induces cell autophagy, and due to the dual roles of autophagy in the survival and death of tumor cells, the effect of inhibition of autophagy on glioblastoma cells remains to be explored. We therefore assessed whether bortezomib is capable of indu...
Source: Molecular and Cellular Biochemistry - October 9, 2013 Category: Biochemistry Authors: Zhang X, Li W, Wang C, Leng X, Lian S, Feng J, Li J, Wang H Tags: Mol Cell Biochem Source Type: research