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Drug: Melatonin

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Total 136 results found since Jan 2013.

Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research

Melatonin Postconditioning Ameliorates Anoxia/Reoxygenation Injury by Regulating Mitophagy and Mitochondrial Dynamics in a SIRT3-Dependent Manner
Eur J Pharmacol. 2021 May 7:174157. doi: 10.1016/j.ejphar.2021.174157. Online ahead of print.ABSTRACTIschaemia/reperfusion (I/R) injury is accompanied by excessive mitochondrial autophagy (mitophagy) and an imbalance in mitochondrial dynamics. Melatonin has been reported to alleviate I/R injury by regulating mitophagy and mitochondrial dynamics. However, the underlying mechanism associated with this activity is not fully understood. The goal of the present study was to investigate whether and how melatonin administration at the beginning of reoxygenation exerts protective effects by regulating mitophagy and mitochondrial d...
Source: European Journal of Pharmacology - May 10, 2021 Category: Drugs & Pharmacology Authors: Yang Bai Yanli Yang Yafen Gao Duomao Lin Zhaoqi Wang Jun Ma Source Type: research

Melatonin attenuates smoking-induced atherosclerosis by activating the Nrf2 pathway via NLRP3 inflammasomes in endothelial cells
Aging (Albany NY). 2021 Apr 4;13. doi: 10.18632/aging.202829. Online ahead of print.ABSTRACTSubstantial evidence suggests that the effects of smoking in atherosclerosis are associated with inflammation mediated by endothelial cells. However, the mechanisms and potential drug therapies for smoking-induced atherosclerosis remain to be clarified. Considering that melatonin exerts beneficial effects in cardiovascular diseases, we examined its effects on cigarette smoke-induced vascular injury. We found that cigarette smoke extract (CSE) treatment induced NLRP3-related pyroptosis in human aortic endothelial cells (HAECs). CSE a...
Source: Aging - April 11, 2021 Category: Biomedical Science Authors: Zhewei Zhao Xuebin Wang Rui Zhang Baitao Ma Shuai Niu Xiao Di Leng Ni Changwei Liu Source Type: research

Melatonin Inhibits the Progression of Oral Squamous Cell Carcinoma via Inducing miR-25-5p Expression by Directly Targeting NEDD9
Melatonin exerts anti-cancer roles in various types of cancers. However, to the best of our knowledge, its role in oral squamous cell carcinoma (OSCC) is unknown. The present study aimed to investigate the role of melatonin and its underlying mechanism in OSCC. MTT, colony formation, wound healing, and transwell invasion assays proved that melatonin played anti-tumor effects in OSCC cells by inhibiting cell viability, proliferation, migration, and invasion in a concentration-dependent manner. The RT-qPCR analysis showed that miR-25-5p was significantly upregulated after melatonin treatment. Further, miR-25-5p might be invo...
Source: Frontiers in Oncology - December 2, 2020 Category: Cancer & Oncology Source Type: research

Role of BMAL1 and CLOCK in regulating the secretion of melatonin in chick retina under monochromatic green light.
Abstract As the circadian pacemaker of birds, the retina possesses the ability to receive light information, generate circadian oscillation, and secrete melatonin. Previous studies have confirmed that monochromatic green light can accelerate the circadian rhythmic expression of clock genes in the chick retina, thereby increasing cAanat mRNA level and melatonin secretion. However, as the core components of the transcriptional-translational negative feedback loop, the role that cBmal1 and cClock plays in the regulation of the retinal molecular clock system and melatonin secretion under monochromatic green light is u...
Source: Chronobiology International - October 28, 2020 Category: Biology Authors: Bian J, Wang Z, Dong Y, Cao J, Chen Y Tags: Chronobiol Int Source Type: research

Melatonin ‑induced miR‑181c‑5p enhances osteogenic differentiation and mineralization of human jawbone‑derived osteoblastic cells.
In conclusion, MEL‑induced expression of miR‑181c‑5p enhanced osteogenic differentiation and calcification of hOB cells. PMID: 32945514 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - September 20, 2020 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Melatonin promotes cardiomyocyte proliferation and heart repair in mice with myocardial infarction via miR-143-3p/Yap/Ctnnd1 signaling pathway.
In this study, we investigated whether melatonin regulated cardiomyocyte proliferation and promoted cardiac repair in mice with myocardial infarction (MI), which was induced by ligation of the left anterior descending coronary artery. We showed that melatonin administration significantly improved the cardiac functions accompanied by markedly enhanced cardiomyocyte proliferation in MI mice. In neonatal mouse cardiomyocytes, treatment with melatonin (1 μM) greatly suppressed miR-143-3p levels. Silencing of miR-143-3p stimulated cardiomyocytes to re-enter the cell cycle. On the contrary, overexpression of miR-143-3p inhibi...
Source: Acta Pharmacologica Sinica - August 23, 2020 Category: Drugs & Pharmacology Authors: Ma WY, Song RJ, Xu BB, Xu Y, Wang XX, Sun HY, Li SN, Liu SZ, Yu MX, Yang F, Ye DY, Gong R, Han ZB, Yu Y, Bamba D, Wang N, Pan ZW, Cai BZ Tags: Acta Pharmacol Sin Source Type: research

Melatonin suppresses Ti-particle-induced inflammatory osteolysis via activation of the Nrf2/Catalase signaling pathway.
Abstract Aseptic loosening induced by osteolysis is recognized as a late complication of joint replacement. Osteoclasts stimulated by Titanium (Ti) nanoparticles play a critical role in periprosthetic osteolysis. Emerging evidence indicates that melatonin, a hormone primarily synthesized by the pineal gland, has been shown an inhibitory effect on osteoclast formation. However, it is unclear whether melatonin could suppress Ti-particle-induced osteoclastogenesis and what the underlying mechanisms were involved in. Herein, we aimed to investigate the effect of melatonin on osteoclast differentiation and osteolysis s...
Source: International Immunopharmacology - August 5, 2020 Category: Allergy & Immunology Authors: Zhu X, Zhang Y, Yang H, He F, Lin J Tags: Int Immunopharmacol Source Type: research

Melatonin ameliorates excessive PINK1/Parkin-mediated mitophagy by enhancing SIRT1 expression in granulosa cells of PCOS.
In conclusion, melatonin protects against mitochondrial injury in granulosa cells of PCOS by enhancing SIRT1 expression to inhibit excessive PINK1/Parkin-mediated mitophagy. PMID: 32343612 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Endocrinology and Metabolism - April 27, 2020 Category: Physiology Authors: Yi S, Zheng B, Zhu Y, Cai Y, Sun H, Zhou J Tags: Am J Physiol Endocrinol Metab Source Type: research

Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway
This study aimed to determine the mechanism by which melatonin inhibits the proliferation of osteoblasts.Main methodsCell viability experiment, DNA fragment detection and alkaline phosphatase (ALP) activity assays were performed to determine the effects of melatonin on the proliferation, apoptosis and differentiation of osteoblasts. We used immunofluorescence to detect the expression of STIM1 in melatonin-treated osteoblasts. STIM1 interference was achieved using a specific siRNA, and a TRPC inhibitor was used to block the influx of Ca2+. The mRNA expression was determined by RT-qPCR, and protein levels were measured by We...
Source: Life Sciences - February 21, 2020 Category: Biology Source Type: research

Melatonin attenuates doxorubicin-induced cardiotoxicity through preservation of YAP expression.
In this study, we examined the possible protective effects of melatonin on doxorubicin-induced cardiotoxicity and explored the underlying mechanisms related to this process. We found that in vitro doxorubicin treatment significantly decreased H9c2 cell viability and induced apoptosis as manifested by increased TUNEL-positive cells, down-regulation of anti-apoptotic protein Bcl-2, as well as up-regulation of pro-apoptotic protein Bax. This was associated with increased reactive oxygen species (ROS) levels and decreased mitochondrial membrane potentials (MMP). In vivo, five weeks of doxorubicin treatment significantly decrea...
Source: J Cell Mol Med - February 17, 2020 Category: Molecular Biology Authors: Li HR, Wang C, Sun P, Liu DD, Du GQ, Tian JW Tags: J Cell Mol Med Source Type: research

GSE142476 The role of Lhx4 and Bsx homeobox genes in the rat adult pineal gland
Contributors : Henrik Hertz ; Martin F Rath ; David C Klein ; Steven L CoonSeries Type : Expression profiling by high throughput sequencingOrganism : Rattus norvegicusHomeobox genes generally encode transcription factors involved in regulating developmental processes. In the pineal gland, a brain structure devoted to nocturnal melatonin synthesis, a number of homeobox genes are also expressed postnatally; among these are the LIM homeobox 4 gene (Lhx4) and the brain ‐specific homeobox gene (Bsx). As part of a larger study, we used of siRNA technology to knock down Lhx4 or Bsx expression in cultured adult rat pinealocytes....
Source: GEO: Gene Expression Omnibus - December 21, 2019 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Rattus norvegicus Source Type: research

Melatonin reverses the oxidative stress and mitochondrial dysfunction caused by LETM1 silencing.
This article is protected by copyright. All rights reserved. PMID: 31777134 [PubMed - as supplied by publisher]
Source: Cell Biology International - November 26, 2019 Category: Cytology Authors: Aral C, Demirkesen S, Bircan R, Yasar Sirin D Tags: Cell Biol Int Source Type: research

Melatonin induces progesterone production in human granulosa-lutein cells through upregulation of StAR expression.
Abstract Steroidogenic acute regulatory protein (StAR) mediates the rate-limiting step in ovarian steroidogenesis and progesterone (P4) synthesis. Melatonin and its receptors are expressed in human granulosa cells, and have been shown to influence basal P4 production. However, previous studies addressing the regulation of StAR expression by melatonin and its impact on P4 secretion yielded contradictory results. Here, we demonstrate that melatonin upregulates StAR expression in primary cultures of human granulosa-lutein (hGL) cells obtained from women undergoing in vitro fertilization (IVF). Using pharmacological i...
Source: Aging - October 15, 2019 Category: Biomedical Science Authors: Fang L, Li Y, Wang S, Yu Y, Li Y, Guo Y, Yan Y, Sun YP Tags: Aging (Albany NY) Source Type: research