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Drug: Melatonin

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Total 136 results found since Jan 2013.

Inhibiting MT2 ‐TFE3‐dependent autophagy enhances melatonin‐induced apoptosis in tongue squamous cell carcinoma
Abstract Autophagy modulation is a potential therapeutic strategy for tongue squamous cell carcinoma (TSCC). Melatonin possesses significant anticarcinogenic activity. However, whether melatonin induces autophagy and its roles in cell death in TSCC are unclear. Herein, we show that melatonin induced significant apoptosis in the TSCC cell line Cal27. Apart from the induction of apoptosis, we demonstrated that melatonin‐induced autophagic flux in Cal27 cells as evidenced by the formation of GFP‐LC3 puncta, and the upregulation of LC3‐II and downregulation of SQSTM1/P62. Moreover, pharmacological or genetic blockage of ...
Source: Journal of Pineal Research - January 11, 2018 Category: Research Authors: Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He, Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou Tags: ORIGINAL ARTICLE Source Type: research

Melatonin protects diabetic heart against ischemia-reperfusion injury, role of membrane receptor-dependent cGMP-PKG activation
This study was designed to determine the role of melatonin membrane receptors in melatonin's cardioprotective actions against diabetic MI/R injury with a focus on cGMP and its downstream effector PKG. Streptozotocin-induced diabetic Sprague-Dawley rats and high-glucose medium-incubated H9c2 cardiomyoblasts were utilized to determine the effects of melatonin against MI/R injury. Melatonin treatment preserved cardiac function and reduced oxidative damage and apoptosis. Additionally, melatonin increased intracellular cGMP level, PKGIα expression, p-VASP/VASP ratio and further modulated myocardial Nrf-2-HO-1 and MAPK signalin...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - December 6, 2017 Category: Molecular Biology Source Type: research

Inhibiting MT2 ‐TFE3‐dependent autophagy enhances melatonin–induced apoptosis in tongue squamous cell carcinoma
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - November 17, 2017 Category: Research Authors: Tengfei Fan, Huifeng Pi, Min Li, Zhenhu Ren, Zhijing He, Feiya Zhu, Li Tian, Manyu Tu, Jia Xie, Mengyu Liu, Yuming Li, Miduo Tan, Gaoming Li, Weijia Qing, Russel J. Reiter, Zhengping Yu, Hanjiang Wu, Zhou Zhou Tags: Original Article Source Type: research

Melatonin protects chondrocytes from impairment induced by glucocorticoids via NAD+-dependent SIRT1
Publication date: Available online 10 August 2017 Source:Steroids Author(s): Wei Yang, Xiaomin Kang, Na Qin, Feng Li, Xinxin Jin, Zhengmin Ma, Zhuang Qian, Shufang Wu Intra-articular injection of glucocorticoids is used to relieve pain and inflammation in osteoarthritis patients, which is occasionally accompanied with the serious side effects of glucocorticoids in collagen-producing tissue. Melatonin is the major hormone released from the pineal gland and its beneficial effects on cartilage has been suggested. In the present study, we investigated the protective role of melatonin on matrix degeneration in chondrocytes ind...
Source: Steroids - August 10, 2017 Category: Drugs & Pharmacology Source Type: research

Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation.
In conclusion, the activation of calmodulin and calmodulin-dependent protein kinase II was confirmed, as shown by the cascade seen in AANAT phosphorylation (***p < 0.001, n = 4). This mechanism was also established by measuring N-acetyl serotonin and melatonin levels. In conclusion, the activation of a TRPV4 present in human ciliary body epithelial cells produced an increase in AANAT phosphorylation and a further melatonin increase by a mechanism in which Ca-calmodulin and the calmodulin-dependent protein kinase II are involved. PMID: 28655604 [PubMed - as supplied by publisher]
Source: Experimental Eye Research - June 24, 2017 Category: Opthalmology Authors: Alkozi HA, Perez de Lara MJ, Pintor J Tags: Exp Eye Res Source Type: research

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3 ‐dependent regulation of oxidative stress and apoptosis
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - May 13, 2017 Category: Research Authors: Mengen Zhai, Buying Li, Weixun Duan, Lin Jing, Bin Zhang, Meng Zhang, Liming Yu, Zhenhua Liu, Bo Yu, Kai Ren, Erhe Gao, Yang Yang, Hongliang Liang, Zhenxiao Jin, Shiqiang Yu Tags: Original Article Source Type: research

Melatonin, a novel selective ATF-6 inhibitor, induces human hepatoma cell apoptosis through COX-2 downregulation.
CONCLUSION: These findings indicate that melatonin as a novel selective ATF-6 inhibitor can sensitize human hepatoma cells to ER stress inducing apoptosis. PMID: 28246472 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - February 13, 2017 Category: Gastroenterology Authors: Bu LJ, Yu HQ, Fan LL, Li XQ, Wang F, Liu JT, Zhong F, Zhang CJ, Wei W, Wang H, Sun GP Tags: World J Gastroenterol Source Type: research

Melatonin alleviates cadmium ‐induced liver injury by inhibiting the TXNIP‐NLRP3 inflammasome
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - January 17, 2017 Category: Research Authors: Zhengwang Cao, Yiliang Fang, Yonghui Lu, Dunxian Tan, Changhong Du, Yuming Li, Qinlong Ma, Junmei Yu, Mengyan Chen, Chao Zhou, Liping Pei, Lei Zhang, Haiying Ran, Mindi He, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research

Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB‐dependent autophagy–lysosome machinery in mouse neuroblastoma cells
Abstract Cadmium (Cd), a highly ubiquitous heavy metal, induces neurotoxicity. Melatonin, a major secretory product of the pineal gland, protects against Cd‐induced neurotoxicity. However, the mechanism that accounts for this protection remains to be elucidated. Herein, we exposed mouse neuroblastoma cells (Neuro‐2a cells) to different concentrations of cadmium chloride (CdCl2) (12.5, 25, and 50 μ mol L−1) for 24 hours. We showed that Cd inhibits autophagosome–lysosome fusion and impairs lysosomal function, subsequently leading to nerve cell death. In addition, Cd decreases the level of transcription factor EB...
Source: Journal of Pineal Research - August 2, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Min Yang, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research

Melatonin ‐induced increase in sensitivity of human hepatocellular carcinoma cells to sorafenib is associated with reactive oxygen species production and mitophagy
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 1, 2016 Category: Research Authors: N éstor Prieto‐Domínguez, Raquel Ordóñez, Anna Fernández, Carolina Méndez‐Blanco, Anna Baulies, Carmen Garcia‐Ruiz, José C. Fernández‐Checa, José L. Mauriz, Javier González‐Gallego Tags: Original Article Source Type: research

Melatonin antagonizes cadmium‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - July 11, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research

Melatonin antagonizes cadmium ‐induced neurotoxicity by activating the transcription factor EB ‐dependent autophagy‐lysosome machinery in mouse neuroblastoma cells
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - July 9, 2016 Category: Research Authors: Min Li, Huifeng Pi, Zhiqi Yang, Russel J. Reiter, Shangcheng Xu, Xiaowei Chen, Chunhai Chen, Lei Zhang, Yang Min, Yuming Li, Pan Guo, Gaoming Li, Manyu Tu, Li Tian, Jia Xie, Mindi He, Yonghui Lu, Min Zhong, Yanwen Zhang, Zhengping Yu, Zhou Zhou Tags: Original Article Source Type: research

Melatonin protects hepatocytes against bile acid-induced mitochondrial oxidative stress via the AMPK-SIRT3-SOD2 pathway.
This study investigates the protective effects of melatonin pretreatment on glycochenodeoxycholic acid (GCDCA)-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. Melatonin markedly decreased mitochondrial ROS (mROS) production in L02 cells treated with 100 μM GCDCA, and inhibited GCDCA-stimulated cytotoxicity. Notably, melatonin exerted its hepatoprotective effects by upregulating sirtuin 3 (SIRT3) activity and its expression level, thus regulating superoxide dismutase 2 (SOD2) acetylation and inhibiting the production of mROS induced by GCDCA. Moreover, siRNA targeting SIRT3 b...
Source: Free Radical Research - February 18, 2016 Category: Research Tags: Free Radic Res Source Type: research

Melatonin Attenuates Early Brain Injury via the Melatonin Receptor/Sirt1/NF-κB Signaling Pathway Following Subarachnoid Hemorrhage in Mice
In conclusion, our results demonstrate that Mel attenuates EBI following SAH via the MR/Sirt1/NF-κB signaling pathway.
Source: Molecular Neurobiology - February 11, 2016 Category: Neurology Source Type: research

Melatonin enhances arsenic trioxide-induced cell death via sustained upregulation of Redd1 expression in breast cancer cells
Publication date: Available online 27 November 2015 Source:Molecular and Cellular Endocrinology Author(s): Sun-Mi Yun, Sang Hyeok Woo, Sang Taek Oh, Sung-Eun Hong, Tae-Boo Choe, Sang-Kyu Ye, Eun-Kyu Kim, Min Ki Seong, Hyun-A Kim, Woo Chul Noh, Jin Kyung Lee, Hyeon-Ok Jin, Yun-Han Lee, In-Chul Park Melatonin is implicated in various physiological functions, including anticancer activity. However, the mechanism(s) of its anticancer activity is not well understood. In the present study, we investigated the combined effects of melatonin and arsenic trioxide (ATO) on cell death in human breast cancer cells. Mela...
Source: Molecular and Cellular Endocrinology - November 27, 2015 Category: Endocrinology Source Type: research