Filtered By:
Drug: Melatonin
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 136 results found since Jan 2013.
Melatonin Inhibits OGD/R-Induced H9c2 Cardiomyocyte Pyroptosis via Regulation of MT2/miR-155/FOXO3a/ARC Axis
Int Heart J. 2022;63(2):327-337. doi: 10.1536/ihj.21-571.ABSTRACTEmerging literature suggests that pyroptosis plays a critical role in ischemia/hypoxia (I/R) -induced myocardial injury. Melatonin has been implicated in attenuating I/R-induced injury of cardiomyocytes. Nevertheless, whether melatonin inhibits I/R-induced pyroptosis of cardiomyocytes and the underlying molecular mechanisms remain unexploited.H9c2 cardiomyocytes were cultured under oxygen-glucose deprivation/reperfusion (OGD/R) condition to establish a myocardial pyroptosis model in vitro. OGD/R-induced pyroptosis was evaluated by CCK-8 assay, IL-1β and IL-1...
Source: International Heart Journal - March 31, 2022 Category: Cardiology Authors: Rui Chen Min Yang Source Type: research
Copolymer micelle-administered melatonin ameliorates hyperosmolarity-induced ocular surface damage through regulating PINK1 mediated mitophagy
CONCLUSIONS: Our findings demonstrated that Mel-Mic ameliorates hyperosmolarity induced ocular surface damage via PINK1 mediated mitophagy and may represent an effective treatment for DED possibly through acting MT1 receptor.PMID:35179400 | DOI:10.1080/02713683.2021.2022163
Source: Current Eye Research - February 18, 2022 Category: Opthalmology Authors: Jing Xu Peng Chen Guangfen Zhao Susu Wei Qiqi Li Chuanlong Guo Qilong Cao Xianggen Wu Guohu Di Source Type: research
Melatonin alleviates doxorubicin-induced mitochondrial oxidative damage and ferroptosis in cardiomyocytes by regulating YAP expression
In this study, we established a Dox-induced cardiotoxicity model in H9c2 cardiomyocytes, zebrafish, and SD rats to explore the mechanism by which Mel alleviates Dox-induced cardiotoxicity. In vivo and in vitro experiments showed that Dox significantly decreased the viability of H9c2 cells, induced apoptosis, myocardial injury, and effectively up-regulated the expression of p-YAP but down-regulated the expression of YAP. Furthermore, we found that Dox significantly up-regulated the expression of ferroptosis-associated protein ACSL4 and down-regulated expression of GPX4. Interestingly, these effects of Dox were reversed foll...
Source: Toxicology and Applied Pharmacology - January 30, 2022 Category: Toxicology Authors: Xiao Sun Ping Sun Dong Zhen Xiangli Xu Li Yang Danni Fu Chengxi Wei Xiaofeng Niu Jiawei Tian Hairu Li Source Type: research
