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Drug: Melatonin

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Total 136 results found since Jan 2013.

Reduced silent information regulator 1 signaling exacerbates myocardial ischemia–reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
In this study, we developed high‐fat diet‐fed streptozotocin (HFD‐STZ) rat, a well‐known type 2 diabetic model, to evaluate the effect of melatonin on MI/R injury with a focus on silent information regulator 1 (SIRT1) signaling, oxidative stress, and PERK/eIF2α/ATF4‐mediated ER stress. HFD‐STZ treated rats were exposed to melatonin treatment in the presence or the absence of sirtinol (a SIRT1 inhibitor) and subjected to MI/R surgery. Compared with nondiabetic animals, type 2 diabetic rats exhibited significantly decreased myocardial SIRT1 signaling, increased apoptosis, enhanced oxidative stress, and ER stress...
Source: Journal of Pineal Research - September 11, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research

Involvement of nuclear receptor RZR/RORγ in melatonin-induced HIF-1α inactivation in SGC-7901 human gastric cancer cells.
Authors: Wang RX, Liu H, Xu L, Zhang H, Zhou RX Abstract The melatonin nuclear receptor is an orphan member of the nuclear receptor superfamily RZR/ROR, which consists of three subtypes (α, β and γ), suggesting that immunomodulatory and antitumor effects through the intracellular action of melatonin depend on nuclear signaling. In the present study, the biological mechanisms of melatonin were elucidated in association with the RZR/RORγ pathway in SGC-7901 human gastric cancer cells under hypoxia. Melatonin suppressed the activity of RZR/RORγ and SUMO-specific protease 1 (SENP1) signaling pathway, which is esse...
Source: Oncology Reports - September 6, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

Membrane receptor‐dependent Notch1/Hes1 activation by melatonin protects against myocardial ischemia reperfusion injury: in vivo and in vitro studies
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 26, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Zhihong Lu, Guolong Zhao, Mengen Zhai, Yang Yang, Jian Yang, Dinghua Yi, Wensheng Chen, Xiaowu Wang, Weixun Duan, Zhenxiao Jin, Shiqiang Yu Tags: Original Article Source Type: research

Reduced SIRT1 signaling exacerbates myocardial ischemia reperfusion injury in type 2 diabetic rats and the protective effect of melatonin
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - August 20, 2015 Category: Research Authors: Liming Yu, Hongliang Liang, Xiaochao Dong, Guolong Zhao, Zhenxiao Jin, Mengen Zhai, Yang Yang, Wensheng Chen, Jincheng Liu, Wei Yi, Jian Yang, Dinghua Yi, Weixun Duan, Shiqiang Yu Tags: Original Article Source Type: research

Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line.
In this study, we investigated the effect of methamphetamine on TNFα expression and NFκB activation in the neuroblastoma cell line SH-SY5Y. We demonstrated the time-dependent effect of methamphetamine on the induction of TNFα expression as well as IκB degradation and NFκB nuclear translocation. Furthermore, we investigated the effect of melatonin on methamphetamine-induced TNFα overexpression and NFκB activation. The results showed that pretreatment with 100nM melatonin could prevent the TNFα overexpression caused by methamphetamine exposure. This attenuating effect was prevented by pre-incubation with luzindole, a...
Source: Neurotoxicology - August 14, 2015 Category: Neurology Authors: Wongprayoon P, Govitrapong P Tags: Neurotoxicology Source Type: research

Abstract 3573: Novel G protein-coupled receptor targets in HER2+ breast cancer
Conclusion: In summary, functional knockdown screening and differential gene expression of GPCRs is a powerful tool for identifying GPCRs as candidate targets in BC. Using the combination of these two approaches, we have discovered that melatonin MT1 receptor as a potential drug target in HER2+ BC cells. The place in therapy for MT1 receptor antagonists, however, still remains to be determined.Citation Format: Raksha Bhat, Puja Yadav, Pavel Christiny, Rachel Schiff, Meghana V. Trivedi. Novel G protein-coupled receptor targets in HER2+ breast cancer. [abstract]. In: Proceedings of the 106th Annual Meeting of the American As...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Bhat, R., Yadav, P., Christiny, P., Schiff, R., Trivedi, M. V. Tags: Experimental and Molecular Therapeutics Source Type: research

HDAC1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - July 17, 2015 Category: Research Authors: Chongxi Fan, Yunhu Pan, Yang Yang, Shouyin Di, Shuai Jiang, Zhiqiang Ma, Tian Li, Zhipei Zhang, Weimiao Li, Xiaofei Li, Russel J. Reiter, Xiaolong Yan Tags: Original Article Source Type: research

Involvement of ROS-alpha v beta 3 integrin-FAK/Pyk2 in the inhibitory effect of melatonin on U251 glioma cell migration and invasion under hypoxia
Conclusions: These results suggest that melatonin exerts anti-migratory and anti-invasive effects on glioma cells in response to hypoxia via ROS-αvβ3 integrin-FAK/Pyk2 signaling pathways. This provides evidence that melatonin may be a potential therapeutic molecule targeting the hypoxic microenvironment of glioma.
Source: Epidemiologic Perspectives and Innovations - March 20, 2015 Category: Epidemiology Authors: Cheng-Shi XuZe-Fen WangXiao-Dong HuangLi-Ming DaiChang-Jun CaoZhi-Qiang Li Source Type: research

Melatonin induces apoptosis of colorectal cancer cells through HDAC4 nuclear import mediated by CaMKII inactivation
In conclusion, the present study provides evidence that melatonin‐induced apoptosis in colorectal cancer LoVo cells largely depend on the nuclear import of HDAC4 and subsequent H3 deacetylation via the inactivation of CaMKIIα. This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - March 1, 2015 Category: Research Authors: Jia‐Yi Wei, Wan‐Ming Li, Lin‐Lin Zhou, Qiu‐Nan Lu, Wei He Tags: Original Article Source Type: research

Melatonin compensates silencing of heat shock protein 70 and suppresses ultraviolet radiation‐induced inflammation in human skin ex vivo and cultured keratinocytes
Abstract Melatonin, a lipophilic compound synthesized and released from the pineal gland, effectively acts against ultraviolet radiation (UVR), one of the main inducers of epidermal damage, skin cancer, inflammation, and DNA photo damage. One of the common known stress protein induced by UVR is heat shock protein 70 (Hsp70), highly expressed in human keratinocytes, providing cellular resistance to such stressors. Here, using human full‐thickness skin and normal human epidermal keratinocytes (NHEK), we investigated the interaction of melatonin and Hsp70 toward UVR‐induced inflammatory and apoptotic responses. The follow...
Source: Journal of Pineal Research - December 9, 2014 Category: Research Authors: Konrad Kleszczyński, Stephanie Zwicker, Stefan Tukaj, Michael Kasperkiewicz, Detlef Zillikens, Ronald Wolf, Tobias W. Fischer Tags: Original Article Source Type: research

Melatonin Improves Mitochondrial Function by Promoting MT1/SIRT1/PGC-1 Alpha-Dependent Mitochondrial Biogenesis in Cadmium-Induced Hepatotoxicity In Vitro
This study investigates the protective effects of melatonin pretreatment on cadmium-induced hepatotoxicity and elucidates the potential mechanism of melatonin-mediated protection. We exposed HepG2 cells to different concentrations of cadmium chloride (2.5, 5, and 10μM) for 12 h. We found that Cd stimulated cytotoxicity, disrupted the mitochondrial membrane potential, increased reactive oxygen species production, and decreased mitochondrial mass and mitochondrial DNA content. Consistent with this finding, Cd exposure was associated with decreased Sirtuin 1 (SIRT1) protein expression and activity, thus promoted acetylatio...
Source: Toxicological Sciences - November 10, 2014 Category: Toxicology Authors: Guo, P., Pi, H., Xu, S., Zhang, L., Li, Y., Li, M., Cao, Z., Tian, L., Xie, J., Li, R., He, M., Lu, Y., Liu, C., Duan, W., Yu, Z., Zhou, Z. Tags: Metals Source Type: research

Melatonin compensates silencing of heat shock protein 70 and suppresses UVR‐induced inflammation in human skin ex vivo and cultured keratinocytes
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - November 1, 2014 Category: Research Authors: Konrad Kleszczyński, Stephanie Zwicker, Stefan Tukaj, Michael Kasperkiewicz, Detlef Zillikens, Ronald Wolf, Tobias W. Fischer Tags: Original Article Source Type: research

Melatonin prevents mitochondrial dysfunction and insulin resistance in rat skeletal muscle
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - May 1, 2014 Category: Research Authors: Bruno G. Teodoro, Flavia G. Baraldi, Igor H. Sampaio, Lucas H. M. Bomfim, André L. Queiroz, Madla A. Passos, Everardo M. Carneiro, Luciane C. Alberici, Ramon Gomis, Fernanda G. Amaral, José Cipolla‐Neto, Michel B Araújo, Tanes Lima, Sérgio Akira Uye Tags: Original Article Source Type: research

Transcriptional and post‐translational regulation of Bim controls apoptosis in melatonin‐treated human renal cancer Caki cells
This article is protected by copyright. All rights reserved.
Source: Journal of Pineal Research - October 14, 2013 Category: Research Authors: Eun Jung Park, Seon Min Woo, Kyoung‐jin Min, Taeg Kyu Kwon Tags: Original Article Source Type: research

SIRT1 inhibition by melatonin exerts antitumor activity in human osteosarcoma cells.
In this study, we assessed the antitumor activity of melatonin against human osteosarcoma cells (9607 cell line) and explored the role of SIRT1 in the activity of melatonin. melatonin treatment resulted in strong antitumor activity, as evidenced not only by reductions in tumor cell vitality, adhesion ability, migration ability and glutathione (GSH) levels but also by increases in the apoptotic index and reactive oxygen species. Additionally, melatonin treatment down-regulated SIRT1 and up-regulated acetylated-p53. Sirtinol (a known SIRT1 inhibitor) and SIRT1 siRNA further enhanced the antitumor activity of melatonin, while...
Source: European Journal of Pharmacology - May 29, 2013 Category: Drugs & Pharmacology Authors: Cheng Y, Cai L, Jiang P, Wang J, Gao C, Feng H, Wang C, Pan H, Yang Y Tags: Eur J Pharmacol Source Type: research