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Condition: Stroke

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Total 302 results found since Jan 2013.

17{beta}-Estradiol Attenuates Hematoma Expansion Through Estrogen Receptor {alpha}/Silent Information Regulator 1/Nuclear Factor-kappa B Pathway in Hyperglycemic Intracerebral Hemorrhage Mice Basic Sciences
Conclusions— E2 treatment prevented hyperglycemia-enhanced HE and improved neurological deficits in ICH mice mediated by ERα/Sirt1/nuclear factor-kappa B pathway. E2 may serve as an alternative treatment to decrease early HE after ICH.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Zheng, Y., Hu, Q., Manaenko, A., Zhang, Y., Peng, Y., Xu, L., Tang, J., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Neuroprotectors Basic Sciences Source Type: research

MicroRNA-424 Protects Against Focal Cerebral Ischemia and Reperfusion Injury in Mice by Suppressing Oxidative Stress Basic Sciences
Conclusions— MiR-424 protects against transient cerebral ischemia/reperfusion injury by inhibiting oxidative stress.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Liu, P., Zhao, H., Wang, R., Wang, P., Tao, Z., Gao, L., Yan, F., Liu, X., Yu, S., Ji, X., Luo, Y. Tags: Acute Cerebral Infarction Basic Sciences Source Type: research

SIRT3 protects cells from hypoxia via PGC-1α- and MnSOD-dependent pathways
Publication date: 12 February 2015 Source:Neuroscience, Volume 286 Author(s): Q. Wang , L. Li , C.Y. Li , Z. Pei , M. Zhou , N. Li Reports suggest that silent information regulation 2 homolog 3 (SIRT3) protects cardiomyocytes from oxidative stress-mediated death. SIRT3, a mitochondrial protein, is an essential regulator of mitochondrial function, and this regulation is important in many cerebrovascular diseases, especially stroke. Here, we investigated the role of SIRT3 in ischemia-induced neuronal death due to oxygen-glucose deprivation (OGD) using an in vitro model of cerebral ischemia. We found that exposure of differ...
Source: Neuroscience - December 25, 2014 Category: Neuroscience Source Type: research

Inhibition of thioredoxin-1 with siRNA exacerbates apoptosis by activating the ASK1-JNK/p38 pathway in brain of a stroke model rats.
Abstract Apoptosis is critical for the development of cerebral ischemia/reperfusion injury. Thioredoxin-1(Trx-1) protein has been reported to have anti-apoptotic effects in a variety of cell types, and it has been implicated in brain injury after middle cerebral artery occlusion (MCAO). Thus, we studied the effects of Trx1 silencing after MCAO in rats and examined whether inhibition of endogenous Trx1 could increase tissue levels of apoptosis. Male Sprague-Dawley rats (N=170) were subjected to 1h of middle cerebral arterial occlusion followed by 24h of reperfusion. Trx1 siRNAs were injected into rat brains 24h pri...
Source: Brain Research - December 22, 2014 Category: Neurology Authors: Wu X, Li L, Zhang L, Wu J, Zhou Y, Zhou Y, Zhao Y, Zhao J Tags: Brain Res Source Type: research

Cofilin Inhibition Restores Neuronal Cell Death in Oxygen–Glucose Deprivation Model of Ischemia
Abstract Ischemia is a condition associated with decreased blood supply to the brain, eventually leading to death of neurons. It is associated with a diverse cascade of responses involving both degenerative and regenerative mechanisms. At the cellular level, the changes are initiated prominently in the neuronal cytoskeleton. Cofilin, a cytoskeletal actin severing protein, is known to be involved in the early stages of apoptotic cell death. Evidence supports its intervention in the progression of disease states like Alzheimer’s and ischemic kidney disease. In the present study, we have hypothesized the possible i...
Source: Molecular Neurobiology - December 20, 2014 Category: Neurology Source Type: research

Critical role of extracellularly secreted neuronal pentraxin 1 in ischemic neuronal death
Conclusions: Collectively, our results demonstrate that extracellular release of NP1 promote hypoxic-ischemic neuronal death possible via surface clustering with GluR1 at synaptic sites and that NP1, not its family member NP2, is involved in the neuronal death mechanisms.
Source: BMC Neuroscience - December 20, 2014 Category: Neuroscience Authors: Shabarish ThatipamulaMir Hossain Source Type: research

Candesartan stimulates reparative angiogenesis in ischemic retinopathy model: role of hemeoxygenase-1 (HO-1)
Abstract Ischemic diseases such as stroke and proliferative retinopathy are characterized by hypoxia-driven release of angiogenic factors such as vascular endothelial growth factor (VEGF). However, revascularization of the ischemic areas is inadequate, resulting in impaired neuro-vascular function. We aim to examine the vascular protective effects of candesartan, an angiotensin receptor blocker, in an ischemic retinopathy mouse model. Vascular density, number of tip cells, and perfusions of capillaries were assessed. Activation of Muller glial cells and levels of peroxynitrite, VEGF, VEGFR2, inducible nitric o...
Source: Angiogenesis - November 25, 2014 Category: Molecular Biology Source Type: research

Recombinant Milk Fat Globule-EGF Factor-8 Reduces Oxidative Stress via Integrin {beta}3/Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase Pathway in Subarachnoid Hemorrhage Rats Basic Sciences
Conclusions— Recombinant MFGE8 attenuated oxidative stress that may be mediated by integrin β3/nuclear factor erythroid 2–related factor 2/HO pathway after SAH. Recombinant MFGE8 may serve as an alternative treatment to ameliorate early brain injury for SAH patients.
Source: Stroke - November 24, 2014 Category: Neurology Authors: Liu, F., Hu, Q., Li, B., Manaenko, A., Chen, Y., Tang, J., Guo, Z., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage Basic Sciences Source Type: research

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism
Publication date: Available online 4 November 2014 Source:Neurochemistry International Author(s): Meiling Sun , Mei Li , Qiao Huang , Feng Han , Jin-hua Gu , Jiaming Xie , Rong Han , Zheng-Hong Qin , Zhipeng Zhou We previously found that TIGAR (TP53-induced glycolysis and apoptosis regulator) was upregulated in response to ischemia/reperfusion insult in a TP53-independent manner. The present study sought to investigate the regulatory mechanisms of TIGAR upregulation in animal and cellular models of stroke. The animal and cellular models of ischemia/reperfusion were produced by transient middle cerebral artery occlusion a...
Source: Neurochemistry International - November 4, 2014 Category: Neuroscience Source Type: research

Remote Ischemic Postconditioning Alleviates Cerebral Ischemic Injury by Attenuating Endoplasmic Reticulum Stress-Mediated Apoptosis
Abstract Remote ischemic postconditioning (RIPostC) has been proved to protect the brain from stroke, but the precise mechanism remains not fully understood. In the present study, we aimed to investigate whether RIPostC attenuates cerebral ischemia-reperfusion injury by abating endoplasmic reticulum (ER) stress response. CHOP, a multifunctional transcription factor in ER stress, regulates the expression of genes related to apoptosis, such as Bim and Bcl-2. Male SD rats were subjected to right middle cerebral artery occlusion (MCAO) for 2 h followed by reperfusion, and RIPostC was induced by three cycles of 10 m...
Source: Translational Stroke Research - October 30, 2014 Category: Neurology Source Type: research

Isoflurane but Not Sevoflurane or Desflurane Aggravates Injury to Neurons In Vitro and In Vivo via p75NTR-NF-ĸB Activation.
CONCLUSIONS:: Isoflurane but not sevoflurane or desflurane postexposure aggravates neurotoxicity in preinjured neurons via activation of p75 and NF-κB. These findings may have implications for the choice of volatile anesthetic being used in patients with or at risk for neuronal injury, specifically in patients with a stroke or history of stroke and in surgical procedures in which neuronal injury is likely to occur, such as cardiac surgery and neurovascular interventions. PMID: 25329094 [PubMed - as supplied by publisher]
Source: Anesthesia and Analgesia - October 17, 2014 Category: Anesthesiology Authors: Schallner N, Ulbrich F, Engelstaedter H, Biermann J, Auwaerter V, Loop T, Goebel U Tags: Anesth Analg Source Type: research

17-beta estradiol inhibits oxidative stress-induced accumulation of AIF into nucleolus and PARP1-dependent cell death via estrogen receptor alpha.
Abstract Oxidative stress-induced DNA damage results in over-activation of poly(ADP-ribose) polymerase 1 (PARP1), leading to parthanatos, a newly discovered cell elimination pathway. Inhibition of PARP1-dependent cell death has shown to improve the outcome of diseases, including stroke, heart ischemia, and neurodegenerative diseases. In the present study we aimed to detect whether estrogen plays a protective role in inhibiting parthanatos. We utilized human mammary adenocarcinoma cells (MCF7) that abundantly express the estrogen receptor alpha and beta (ERα and ERβ). Parthanatos was induced by challenging the ce...
Source: Toxicology Letters - September 30, 2014 Category: Toxicology Authors: Batnasan E, Wang R, Wen J, Ke Y, Li X, Bohio AA, Zeng X, Huo H, Han L, Boldogh I, Ba X Tags: Toxicol Lett Source Type: research

Follistatin-Like 1 Attenuates Apoptosis via Disco-Interacting Protein 2 Homolog A/Akt Pathway After Middle Cerebral Artery Occlusion in Rats Basic Sciences
Conclusions— Recombinant FSTL1 decreases neuronal apoptosis and improves neurological deficits through phosphorylation of Akt by activation of its receptor DIP2A after MCAO in rats. Thus, FSTL1 may have potentials as a treatment for patients with ischemic stroke.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Liang, X., Hu, Q., Li, B., McBride, D., Bian, H., Spagnoli, P., Chen, D., Tang, J., Zhang, J. H. Tags: Animal models of human disease, Apoptosis, Neuroprotectors Basic Sciences Source Type: research

Equol is neuroprotective during focal cerebral ischemia and reperfusion that involves p-Src and gp91phox.
Abstract Both of gp91(phox) (an isoform of nicotinamide adenine dinucleotide phosphate reduced oxidases) and Src (a non-receptor protein tyrosine kinase) are abundantly expressed in the brain and play a prominent role in mediating ischemic alteration in neurons. The inhibitory strategy of them is believed to be the promising treatment of stroke. The present study was designed to investigate the effect of equol (0.625-2.5 mg•kg(-1), i.g. for 3 days), a predominant active metabolite of daidzein, on neuroprotection against cerebral ischemia/reperfusion injury in rats and the underlying mechanisms. We found that equ...
Source: Current Neurovascular Research - September 7, 2014 Category: Neurology Authors: Wei YU, Wang Y, Zhou DX, Zhao LM, Li GR, Deng XL Tags: Curr Neurovasc Res Source Type: research