Filtered By:
Condition: Stroke

This page shows you your search results in order of date. This is page number 20.

Order by Relevance | Date

Total 302 results found since Jan 2013.

LRRC8A protein is indispensable for swelling-activated and the ATP-induced release of excitatory amino acids in rat astrocytes.
This article is protected by copyright. All rights reserved. PMID: 25172945 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - August 28, 2014 Category: Physiology Authors: Hyzinski-García MC, Rudkouskaya A, Mongin AA Tags: J Physiol Source Type: research

Upregulation of Hsp72 mediates anoxia/reoxygention neuroprotection in the freshwater turtle via modulation of ROS.
Abstract The neuroprotective role of Hsp72 has been demonstrated in several ischemic/stroke models to occur primarily through mediation of apoptotic pathways, and a number of heat shock proteins are upregulated in animal models capable of extended anoxic survival. In the present study, we investigated the role of Hsp72 on cell death and apoptotic regulators in one anoxia tolerant model system, the freshwater turtle Trachemys scripta. Since Hsp72 is known to regulate apoptosis through interactions with Bcl-2, we manipulated the levels of Hsp72 and Bcl-2 with siRNA in neuronally enriched primary cell cultures and ex...
Source: Brain Research - August 5, 2014 Category: Neurology Authors: Kesaraju S, Nayak G, Prentice HM, Milton SL Tags: Brain Res Source Type: research

Activation of T‐LAK‐cell‐originated protein kinase‐mediated antioxidation protects against focal cerebral ischemia‐reperfusion injury
Conclusions: These data reveal that activating TOPK confers neuroprotection against focal cerebral ischemia‐reperfusion injury by anti‐oxidative function, in part through activation of the ERK pathway. This article is protected by copyright. All rights reserved.
Source: FEBS Journal - July 26, 2014 Category: Research Authors: Haiping Zhao, Rongliang Wang, Zhen Tao, Feng Yan, Li Gao, Xiangrong Liu, Ningqun Wang, Lianqiu Min, Yujie Jia, Yongmei Zhao, Xunming Ji, Yumin Luo Tags: Original Article Source Type: research

Integrin β3 mediates cerebrovascular remodelling through Src/ClC‐3 volume‐regulated Cl− channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediates cerebrovascular remodelling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - June 10, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: RESEARCH PAPER Source Type: research

IL-8 enhances angiogenesis of human bone marrow mesenchymal stem cells by increasing vascular endothelial growth factor.
In conclusion, IL-8 stimulates VEGF production in hBM-MSCs in part via the PI3K/Akt and MAPK/ERK signal transduction pathways and that administration of IL-8-treated hBM-MSCs increases angiogenesis after stroke. This approach may be used to optimize MSC-based therapies for numerous diseases including stroke, myocardial ischemia, and spinal cord injury. PMID: 24797366 [PubMed - as supplied by publisher]
Source: Cell Biology International - May 5, 2014 Category: Cytology Authors: Hou Y, Ryu CH, Jun JA, Kim SM, Jeong CH, Jeun SS Tags: Cell Biol Int Source Type: research

Down-Regulation of miRNA-30a Alleviates Cerebral Ischemic Injury Through Enhancing Beclin 1-Mediated Autophagy.
In this study, the effects of miRNA-30a on ischemic injury in N2A cells and cultured cortical neurons after oxygen glucose deprivation (OGD), and mouse brain with MCAO-induced ischemic stroke were evaluated. The results showed that miRNA-30a expression levels were up regulated in the brain of mice after 6 h MCAO without reperfusion, but significantly down regulated in the peri-infarct region of mice with 1 h MCAO/24 h reperfusion and in N2A cells after 1 h OGD/6-48 h reoxygenation. Both the conversion ratio of microtubule-associated protein 1 light chain 3 (LC3)-II/LC3-I and Beclin 1 protein level increased in N2A cel...
Source: Neurochemical Research - April 26, 2014 Category: Neuroscience Authors: Wang P, Liang J, Li Y, Li J, Yang X, Zhang X, Han S, Li S, Li J Tags: Neurochem Res Source Type: research

Integrin β3 mediated cerebrovascular remodeling through Src/ClC‐3 volume regulated Cl‐ channel signalling pathway
Conclusions and ImplicationsIntegrin β3 mediated cerebrovascular remodeling during hypertension via Src/ClC‐3 signalling pathway.
Source: British Journal of Pharmacology - February 25, 2014 Category: Drugs & Pharmacology Authors: Jia‐Wei Zeng, Xiao‐Guang Wang, Ming‐Ming Ma, Xiao‐Fei Lv, Jie Liu, Jia‐Guo Zhou, Yong‐Yuan Guan Tags: Research Paper Source Type: research

Stat3 mediates LIF‐induced protection of astrocytes against toxic ROS by upregulating the UPC2 mRNA pool
Reactive oxygen species (ROS) have been implicated in various types of CNS damage, including stroke. We used a cultured astrocyte model to explore mechanisms of survival of CNS cells following ROS damage. We found that pretreatment with leukemia inhibitory factor (LIF) preserves astrocytes exposed to toxic levels of t‐BHP by inhibiting an increase in intracellular ROS following t‐BHP treatment. Astrocytes lacking functional Stat3 did not benefit from the pro‐survival or antioxidant effects of LIF. Inhibition of mitochondrial uncoupling protein 2 (UCP2) using a chemical inhibitor or siRNA abrogates the prosurvival eff...
Source: Glia - December 5, 2013 Category: Neurology Authors: Daniel W. Lapp, Samuel S. Zhang, Colin J. Barnstable Tags: Research Article Source Type: research

Ischemic neurons activate astrocytes to disrupt endothelial barrier via increasing VEGF expression
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - November 20, 2013 Category: Neurology Authors: Ying‐Na Li, Rong Pan, Xu‐Jun Qin, Wei‐Lin Yang, Zhifeng Qi, Wenlan Liu, Ke Jian Liu Tags: Original Article Source Type: research

TRPM4 inhibition promotes angiogenesis after ischemic stroke.
Abstract Transient receptor potential melastatin 4 (TRPM4) is a voltage-dependent, nonselective cation channel. Under pathological conditions, sustained activation of TRPM4 leads to oncotic cell death. Here, we report the upregulation of TRPM4 in vascular endothelium following hypoxia/ischemia in vitro and in vivo. In human umbilical vein endothelial cells, TRPM4 expression was increased at both the mRNA and protein levels following oxygen-glucose deprivation. Blocking TRPM4 with 9-phenanthrol greatly enhanced tube formation on Matrigel. In a rat permanent middle cerebral artery occlusion model, TRPM4 was upregula...
Source: Pflugers Archiv : European Journal of Physiology - September 17, 2013 Category: Physiology Authors: Loh KP, Ng G, Yu CY, Fhu CK, Yu D, Vennekens R, Nilius B, Soong TW, Liao P Tags: Pflugers Arch Source Type: research

Ion transporters in brain endothelial cells that contribute to formation of brain interstitial fluid.
Abstract Ions and water transported across the endothelium lining the blood-brain barrier contribute to the fluid secreted into the brain and are important in maintaining appropriate volume and ionic composition of brain interstitial fluid. Changes in this secretion process may occur after stroke. The present study identifies at transcript and protein level ion transporters involved in the movement of key ions and examines how levels of certain of these alter following oxidative stress. Immunohistochemistry provides evidence for Cl(-)/HCO3 (-) exchanger, AE2, and Na(+), HCO3 (-) cotransporters, NBCe1 and NBCn1, on...
Source: Pflugers Archiv : European Journal of Physiology - September 11, 2013 Category: Physiology Authors: Mokgokong R, Wang S, Taylor CJ, Barrand MA, Hladky SB Tags: Pflugers Arch Source Type: research

Genes, Vol. 4, Pages 435-456: siRNA Treatment: “A Sword-in-the-Stone” for Acute Brain Injuries
Ever since the discovery of small interfering ribonucleic acid (siRNA) a little over a decade ago, it has been highly sought after for its potential as a therapeutic agent for many diseases. In this review, we discuss the promising possibility of siRNA to be used as a drug to treat acute brain injuries such as stroke and traumatic brain injury. First, we will give a brief and basic overview of the principle of RNA interference as an effective mechanism to decrease specific protein expression. Then, we will review recent in vivo studies describing siRNA research experiments/treatment options for acute brain diseases. Lastly...
Source: Genes - September 5, 2013 Category: Genetics & Stem Cells Authors: Andrew FukudaJerome Badaut Tags: Review Source Type: research

Activation of STAT3 is involved in neuroprotection by electroacupuncture pretreatment via cannabinoid CB1 receptors in rats.
In conclusion, EA pretreatment enhances STAT3 activation via CB1R to protect against cerebral ischemia, suggesting that STAT3 activation may be a novel target for stroke intervention. PMID: 23880371 [PubMed - as supplied by publisher]
Source: Brain Research - July 20, 2013 Category: Neurology Authors: Zhou H, Zhang Z, Wei H, Wang F, Guo F, Gao Z, Marsicano G, Wang Q, Xiong L Tags: Brain Res Source Type: research

The Involvement of Programmed Cell Death 5 (PDCD5) in the Regulation of Apoptosis in Cerebral Ischemia/Reperfusion Injury.
CONCLUSIONS: PDCD5-induced apoptosis and over-expression of PDCD5 are harmful to the ischemic neurons in vivo. Meanwhile, the inhibition of PDCD5 may be protective via reducing the apoptotic-related protein such as p53, Bax, and caspase-3. This observation may have potential for the treatment of ischemic cerebral stroke. PMID: 23638963 [PubMed - as supplied by publisher]
Source: CNS Neuroscience and Therapeutics - May 3, 2013 Category: Neuroscience Authors: Chen CH, Jiang Z, Yan JH, Yang L, Wang K, Chen YY, Han JY, Zhang JH, Zhou CM Tags: CNS Neurosci Ther Source Type: research

A dietary polyphenol resveratrol acts to provide neuroprotection in recurrent stroke models by regulating AMPK and SIRT1 signaling, thereby reducing energy requirements during ischemia
In this study, elderly male Wistar rats received a combination of two mild transient middle cerebral artery occlusions (tMCAOs) as an in vivo recurrent ischemic model. Primary cultured cortical neuronal cells subjected to combined oxygen–glucose deprivation (OGD) were used as an in vitro recurrent ischemic model. RSV administration significantly reduced infarct volumes, improved behavioral deficits and protected neuronal cells from cell death in recurrent ischemic stroke models in vivo and in vitro. RSV treatments significantly increased the intracellular NAD+/NADH ratio, AMPK and SIRT1 activities, decreased energy assum...
Source: European Journal of Neuroscience - March 5, 2013 Category: Neuroscience Authors: Li‐Mei Wang, Yong‐Jiu Wang, Min Cui, Wen‐Juan Luo, Xiao‐Ji Wang, Philip A. Barber, Zhe‐Yu Chen Tags: Research Report Source Type: research