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Condition: Stroke
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Total 302 results found since Jan 2013.
Long non-coding RNA MIAT impairs neurological function in ischemic stroke via up-regulating microRNA-874-3p-targeted IL1B
CONCLUSION: Shortly, this study figures out that MIAT impairs neurological function in IS via up-regulating miR-874-3p-targeted IL1B.PMID:34265390 | DOI:10.1016/j.brainresbull.2021.07.005
Source: Brain Research Bulletin - July 15, 2021 Category: Neurology Authors: Shuai Zhang Yue Zhang Na Wang Yu Wang Huan Nie Yueyue Zhang Huiying Han Shan Wang Wenjuan Liu Chunrui Bo Source Type: research
Long noncoding RNA Meg3 mediates ferroptosis induced by oxygen and glucose deprivation combined with hyperglycemia in rat brain microvascular endothelial cells, through modulating the p53/GPX4 axis
In this study, rat brain microvascular endothelial cells (RBMVECs) were exposed to 6 h of oxygen and glucose deprivation (OGD), and subsequent reperfusionvia incubating cells with glucose of various high concentrations for 24 h to imitateinvitro diabetic brain ischemic injury. It was shown that the marker events of ferroptosis and increasedMeg3 expression occurred after the injury induced by OGD combined with hyperglycemia. However, all ferroptotic events were reversed with the treatment ofMeg3-siRNA. Moreover, in this in vitro model, p53 was also characterized as a downstream target ofMeg3. Furthermore, p53 knockdown prot...
Source: European Journal of Histochemistry - July 2, 2021 Category: Biomedical Science Authors: Cheng Chen, Yan Huang, Pingping Xia, Fan Zhang, Longyan Li, E Wang, Qulian Guo, Zhi Ye Source Type: research
Melatonin protects against focal cerebral ischemia-reperfusion injury in diabetic mice by ameliorating mitochondrial impairments: involvement of the Akt-SIRT3-SOD2 signaling pathway
Aging (Albany NY). 2021 Jun 11;13. doi: 10.18632/aging.203137. Online ahead of print.ABSTRACTDiabetic patients are more vulnerable to cerebral ischemia-reperfusion (CIR) injury and have a worse prognosis and higher mortality after ischemic stroke than non-diabetic counterparts. Melatonin can exert neuroprotective effects against CIR injury in nondiabetic animal models. However, its effects on diabetic CIR injury and the underlying mechanisms remain unclarified. Herein, we found that melatonin administration improved neurological deficit, cerebral infarct volume, brain edema, and cell viability, reduced mitochondrial swelli...
Source: Aging - June 12, 2021 Category: Biomedical Science Authors: Lian Liu Quan Cao Wenwei Gao Bingyu Li Zhongyuan Xia Bo Zhao Source Type: research
SIRT1/PGC-1 α signaling activation by mangiferin attenuates cerebral hypoxia/reoxygenation injury in neuroblastoma cells
This study is designed to investigate the protective effect of MGF treatment in the setting of cerebral IRI and to elucidate the potential mechanisms. We first evaluated the toxicity of MGF and chose the safe concentrations for the following experiments. MGF exerted obvious neuroprotection against hypoxia/reoxygenation (HR)-induced injury, indicated by restored cell viability and cell morphology, decreased lactate dehydrogenase (LDH) release and reactive oxygen species generation. MGF also restored the protein expressions of SIRT1, PGC-1α, Nrf2, NQO1, HO-1, NRF1, UCP2, and Bcl2 down-regulated by HR treatment. However, SIR...
Source: European Journal of Pharmacology - June 11, 2021 Category: Drugs & Pharmacology Authors: Mengfan Chen Zheng Wang Wenying Zhou Chenxi Lu Ting Ji Wenwen Yang Zhenxiao Jin Ye Tian Wangrui Lei Songdi Wu Qi Fu Zhen Wu Xue Wu Mengzhen Han Minfeng Fang Yang Yang Source Type: research
Galectin-1 Contributes to Vascular Remodeling and Blood Flow Recovery After Cerebral Ischemia in Mice
AbstractGalectin-1 is found in the vasculature and has been confirmed to promote angiogenesis in several cancer models. Furthermore, galectin-1 has been demonstrated to improve the recovery of cerebral ischemia. However, whether vascular remodeling contributes to this improvement is still unknown. In the present study, photochemical cerebral ischemia was induced in both galectin-1-treated (2 μg/day,i.c.v, 3 days) and galectin-1 knockout mice. Laser speckle imaging and immunofluorescent staining demonstrated that circulation and vascular remodeling in the ischemic cortex were improved by galectin-1 treatment but disrup...
Source: Translational Stroke Research - May 10, 2021 Category: Neurology Source Type: research
BYHWD Alleviates Inflammatory Response by NIK-Mediated Repression of the Noncanonical NF- κB Pathway During ICH Recovery
Intracerebral hemorrhage (ICH) is a life-threatening type of stroke that lacks effective treatments. The inflammatory response following ICH is a vital response that affects brain repair and organism recovery. The nuclear factor κB (NF-κB) signaling pathway is considered one of the most important inflammatory response pathways and one of its response pathways, the noncanonical NF-κB signaling pathway, is known to be associated with persistent effect and chronic inflammation. NF-κB–inducing kinase (NIK) via the noncanonical NF-κB signaling plays a key role in controlling inflammation. Here, we investigated potential ...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research
NmFGF1-Regulated Glucolipid Metabolism and Angiogenesis Improves Functional Recovery in a Mouse Model of Diabetic Stroke and Acts via the AMPK Signaling Pathway
Diabetes increases the risk of stroke, exacerbates neurological deficits, and increases mortality. Non-mitogenic fibroblast growth factor 1 (nmFGF1) is a powerful neuroprotective factor that is also regarded as a metabolic regulator. The present study aimed to investigate the effect of nmFGF1 on the improvement of functional recovery in a mouse model of type 2 diabetic (T2D) stroke. We established a mouse model of T2D stroke by photothrombosis in mice that were fed a high-fat diet and injected with streptozotocin (STZ). We found that nmFGF1 reduced the size of the infarct and attenuated neurobehavioral deficits in our mous...
Source: Frontiers in Pharmacology - May 7, 2021 Category: Drugs & Pharmacology Source Type: research
Transforming growth factor ‑β1 functions as a competitive endogenous RNA that ameliorates intracranial hemorrhage injury by sponging microRNA‑93‑5p
Mol Med Rep. 2021 Jul;24(1):499. doi: 10.3892/mmr.2021.12138. Epub 2021 May 6.ABSTRACTIntracerebral hemorrhage (ICH) has the highest mortality rate of all stroke subtypes but an effective treatment has yet to be clinically implemented. Transforming growth factor‑β1 (TGF‑β1) has been reported to modulate microglia‑mediated neuroinflammation after ICH and promote functional recovery; however, the underlying mechanisms remain unclear. Non‑coding RNAs such as microRNAs (miRNAs) and competitive endogenous RNAs (ceRNAs) have surfaced as critical regulators in human disease. A known miR‑93 target, nuclear factor eryth...
Source: Molecular Medicine - May 6, 2021 Category: Molecular Biology Authors: Han Wang Xianming Cao Xiaoqing Wen Dongling Li Yetong Ouyang Bing Bao Yuqin Zhong Zhengfang Qin Min Yin Zhiying Chen Xiaoping Yin Source Type: research
