Filtered By:
Condition: Translocation

This page shows you your search results in order of relevance. This is page number 14.

Order by Relevance | Date

Total 1410 results found since Jan 2013.

Qiliqiangxin inhibits angiotensin II‐induced transdifferentiation of rat cardiac fibroblasts through suppressing interleukin‐6
This study aimed to investigate the effects of QL on angiotensin II (AngII)‐induced CFs transdifferentiation. Study was performed on in vitro cultured CFs from Sprague–Dawley rats. CFs differentiation was induced by AngII, which was attenuated by QL through reducing transforming growth factor‐β1 (TGF‐β1) and α‐smooth muscle actin (α‐SMA). Our data showed that AngII‐induced IL‐6 mRNA as well as typeI and typeIII collagens were reduced by QL. IL‐6 deficiency could suppress TGF‐β1 and α‐SMA, and both IL‐6 siRNA and QL‐mediated such effect was reversed by foresed expression of recombined IL‐6....
Source: Journal of Cellular and Molecular Medicine - March 6, 2015 Category: Molecular Biology Authors: Jingmin Zhou, Kun Jiang, Xuefeng Ding, Mingqiang Fu, Shijun Wang, Lingti Zhu, Tao He, Jingfeng Wang, Aijun Sun, Kai Hu, Li Chen, Yunzeng Zou, Junbo Ge Tags: Original Article Source Type: research

Qiliqiangxin inhibits angiotensin II-induced transdifferentiation of rat cardiac fibroblasts through suppressing interleukin-6.
This study aimed to investigate the effects of QL on angiotensin II (AngII)-induced CFs transdifferentiation. Study was performed on in vitro cultured CFs from Sprague-Dawley rats. CFs differentiation was induced by AngII, which was attenuated by QL through reducing transforming growth factor-β1 (TGF-β1 ) and α-smooth muscle actin (α-SMA). Our data showed that AngII-induced IL-6 mRNA as well as typeI and typeIII collagens were reduced by QL. IL-6 deficiency could suppress TGF-β1 and α-SMA, and both IL-6 siRNA and QL-mediated such effect was reversed by foresed expression of recombined IL-6. Increase in actin stress f...
Source: J Cell Mol Med - March 6, 2015 Category: Molecular Biology Authors: Zhou J, Jiang K, Ding X, Fu M, Wang S, Zhu L, He T, Wang J, Sun A, Hu K, Chen L, Zou Y, Ge J Tags: J Cell Mol Med Source Type: research

Diallyl trisufide protects against oxygen glucose deprivation -induced apoptosis by scavenging free radicals via the PI3K/Akt -mediated Nrf2/HO-1 signaling pathway in B35 neural cells.
Abstract Oxidative stress contributes to development of ischemic brain damage. Many antioxidants have been proven effective in ameliorating cerebral ischemia injury by inhibiting oxidative stress. DATS, an organosulfuric component of garlic oil, exhibits antioxidative effects. In present study, we used OGD model to investigate the neuroprotective effects of DATS and the mechanisms related to these effects. B35 neural cells exposed to OGD caused a decrease in cell viability and increases in the percentage of apoptotic cells and the level of intracellular cleaved caspase-3, all of which were markedly attenuated by D...
Source: Brain Research - April 17, 2015 Category: Neurology Authors: Li Li G, Wang BA, Hua Xu X, Qin Y, Rong Bai S, Rong J, Deng T, Li Q Tags: Brain Res Source Type: research

PKC{varepsilon}-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis
Conclusions PKC activity in the vascular endothelium regulates HO-1 via a pathway requiring CREB1 and Nrf2. Given the potent protective actions of HO-1, we propose that this mechanism is an important contributor to the emerging role of PKC in the maintenance of endothelial homeostasis and resistance to injury.
Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Mylroie, H., Dumont, O., Bauer, A., Thornton, C. C., Mackey, J., Calay, D., Hamdulay, S. S., Choo, J. R., Boyle, J. J., Samarel, A. M., Randi, A. M., Evans, P. C., Mason, J. C. Tags: Vascular biology Source Type: research

The role of exportin 6 in cytoskeletal-mediated cell death and cell adhesion in human non-small-cell lung carcinoma cells following doxorubicin treatment.
In conclusion, we showed that downregulation of exportin 6 induced necrotic cell death. Moreover, the observed alterations of cell adhesion suggest the key role of cytoplasmic F-actin in maintaining intercellular junctional complexes and/or focal adhesion properties and the importance of the balance between nuclear and cytoplasmic F-actin pools. PMID: 25308735 [PubMed - in process]
Source: Folia Histochemica et Cytobiologica - June 3, 2015 Category: Cytology Tags: Folia Histochem Cytobiol Source Type: research

Topo II Inhibitors Induce CETP Expression and RCT Gene Regulation
In this study we determined if Topo II activity can influence cholesterol metabolism by regulating hepatic CETP expression. Inhibition of Topo II by etoposide, teniposide, or Topo II siRNA increased CETP expression in human hepatic cell line, HepG2 cells, which was associated with increased CETP secretion and mRNA expression. Meanwhile, inhibition of LXR expression by LXR siRNA attenuated induction of CETP expression by etoposide and teniposide. Etoposide and teniposide induced LXRα expression and LXRα/β nuclear translocation while inhibiting expression of receptor interacting protein 140 (RIP140), an LXR co-repressor. ...
Source: Journal of Biological Chemistry - June 4, 2015 Category: Chemistry Authors: Liu, M., Chen, Y., Zhang, L., Wang, Q., Ma, X., Li, X., Xiang, R., Zhu, Y., Qin, S., Yu, Y., Jiang, X.-c., Duan, Y., Han, J. Tags: Lipids Source Type: research

Visfatin promotes osteosarcoma cell migration and invasion via induction of epithelial-mesenchymal transition.
Authors: Cheng G, Liu C, Sun X, Zhang L, Liu L, Ouyang J, Li B Abstract Visfatin is considered to be a biomarker in various types of cancers. However, no evidence has been reported for the direct effect of visfatin on osteosarcoma cell metastasis. The aims of the present study were to investigate the influence of visfatin on the migration and invasion of osteosarcoma cells and clarify the underlying mechanism. The expression levels of epithelial-mesenchymal transition (EMT) markers, as well as the transcriptional factor Snail-1, were first detected at both the protein and mRNA levels in U2OS osteosarcoma cells afte...
Source: Oncology Reports - June 15, 2015 Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

PPAR-γ Ameliorates Neuronal Apoptosis and Ischemic Brain Injury via Suppressing NF-κB-Driven p22phox Transcription
Abstract Peroxisome proliferator-activated receptor-gamma (PPAR-γ), a stress-induced transcription factor, protects neurons against ischemic stroke insult by reducing oxidative stress. NADPH oxidase (NOX) activation, a major driving force in ROS generation in the setting of reoxygenation/reperfusion, constitutes an important pathogenetic mechanism of ischemic brain damage. In the present study, both transient in vitro oxygen-glucose deprivation and in vivo middle cerebral artery (MCA) occlusion-reperfusion experimental paradigms of ischemic neuronal death were used to investigate the interaction between PPAR-γ a...
Source: Molecular Neurobiology - June 24, 2015 Category: Neurology Source Type: research

Effect of Salusin-β on Peroxisome Proliferator-Activated Receptor Gamma Gene Expression in Vascular Smooth Muscle Cells and its Possible Mechanism
Conclusion: I#x03BA;Bα-HDAC3 pathway may contribute to salusin-β-induced inhibition of PPAR#x03B3; gene expression in VSMCs.Cell Physiol Biochem 2015;36:2466-2479
Source: Cellular Physiology and Biochemistry - August 9, 2015 Category: Cytology Source Type: research

Abstract 149: Overexpression of the long non-coding RNA PVT1 and its role in cervical carcinogenesis
Although it is becoming increasingly clear that long non-coding RNAs (lncRNAs) are intricately involved in numerous cancer types, the mechanisms by which they influence carcinogenesis remain poorly understood. The plasmacytoma variant translocation 1 gene (PVT1) is a lncRNA that has been designated as an oncogene due to its contribution to the phenotype of multiple cancers. Further, our lab has recently demonstrated that human papillomavirus (HPV) integration, a hallmark of invasive cervical cancer (ICC), into the PVT1 locus occurs in multiple cervical tumors. The present study was designed to investigate the role of PVT1 ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Iden, M., Fye, S., Ramchandran, R., Rader, J. S. Tags: Molecular and Cellular Biology Source Type: research

Abstract 479: Inhibition of the splicing of the EWS-FLI1 fusion transcript reverses EWS-FLI1 driven oncogenic expression in Ewing sarcoma
This study has implications for the treatment of ES through inhibition of proteins required for expression of the EWS-FLI1 transcript and identifies a candidate lead compound for further clinical development. Our findings may also open up strategies for treatment of other cancers driven by fusion oncogenes.Citation Format: Patrick J. Grohar, Suntae Kim, Sara Haddock, Guillermo Rangel Rivera, Matt Harlow, Nichole K. Maloney, Konrad Huppi, Kristen Gehlhaus, Magdalena Grandin, Carleen Klumpp-Thomas, Eugen Buehler, Lee J. Helman, Scott E. Martin, Natasha J. Caplen. Inhibition of the splicing of the EWS-FLI1 fusion transcript r...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Grohar, P. J., Kim, S., Haddock, S., Rangel Rivera, G., Harlow, M., Maloney, N. K., Huppi, K., Gehlhaus, K., Grandin, M., Klumpp-Thomas, C., Buehler, E., Helman, L. J., Martin, S. E., Caplen, N. J. Tags: Tumor Biology Source Type: research

Abstract 4678: A novel nuclear transporter for androgen receptor and AR-variant-7 in castration resistant prostate cancer: Ideal therapeutic target
Conclusions: We identified novel (i) transporter of AR and (ii) approach for treating CRPC in men.Citation Format: Aijaz Parray, Hifzur R. Siddique, Alyssa Langfald, Pooja Singh, Mikihiko Naito, Robert Matusik, Ingo Schmitz, Shahriar Koochekpour, Badrinath R. Konety, Mohammad Saleem. A novel nuclear transporter for androgen receptor and AR-variant-7 in castration resistant prostate cancer: Ideal therapeutic target. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 4678. ...
Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Parray, A., Siddique, H. R., Langfald, A., Singh, P., Naito, M., Matusik, R., Schmitz, I., Koochekpour, S., Konety, B. R., Saleem, M. Tags: Endocrinology Source Type: research

Anticancer activity of Ashwagandha against human head and neck cancer cell lines
ConclusionsThese suggest that MEAG and WA may be potential natural materials for the treatment of HNSCC.
Source: Journal of Oral Pathology and Medicine - August 1, 2015 Category: Pathology Authors: Haeng‐Eun Lee, Ji‐Ae Shin, Joseph H. Jeong, Jae‐Gyu Jeon, Min‐Ho Lee, Sung‐Dae Cho Tags: Original Article Source Type: research

Tetramethylpyrazine prevents ethanol-induced hepatocyte injury via activation of nuclear factor erythroid 2-related factor 2
Publication date: 15 November 2015 Source:Life Sciences, Volume 141 Author(s): Chunfeng Lu, Yuanyuan Jiang, Feng Zhang, Jiangjuan Shao, Li Wu, Xiafei Wu, Naqi Lian, Lianyun Chen, Huanhuan Jin, Qin Chen, Yin Lu, Shizhong Zheng Aims Inhibiting the major features of alcoholic liver disease (ALD) such as lipid accumulation and oxidative stress is a promising strategy of treating ALD. Tetramethylpyrazine (TMP) has curative effects on various diseases. However, the effects of TMP on ethanol-induced hepatocyte injury and the related mechanisms remain unclear. The aim of this study is to elucidate the effects of TMP ...
Source: Life Sciences - October 4, 2015 Category: Biology Source Type: research

CCL18/PITPNM3 enhances migration, invasion, and EMT through the NF-κB signaling pathway in hepatocellular carcinoma
Abstract Chemokine ligand 18 (CCL18) has been associated with hepatocellular carcinoma (HCC) metastasis. Here, we demonstrated a novel mechanism through which CCL18 enhances cell migration, invasion, and epithelial–mesenchymal transition (EMT) in HCC. (1) Using immunohistochemistry, we analyzed the expression of PITPNM3, a molecule that correlated with CCL18 signaling, in 149 HCC tissue specimens. The results showed that PITPNM3 expression is highly associated with tumor metastasis and differentiation; (2) in vitro experiments showed that CCL18 enhances cell migration, invasion, and EMT in PITPNM3(+) HCC cells b...
Source: Tumor Biology - October 8, 2015 Category: Cancer & Oncology Source Type: research