PKC{varepsilon}-CREB-Nrf2 signalling induces HO-1 in the vascular endothelium and enhances resistance to inflammation and apoptosis

Conclusions
PKC activity in the vascular endothelium regulates HO-1 via a pathway requiring CREB1 and Nrf2. Given the potent protective actions of HO-1, we propose that this mechanism is an important contributor to the emerging role of PKC in the maintenance of endothelial homeostasis and resistance to injury.

Source: Cardiovascular Research - May 14, 2015 Category: Cardiology Authors: Mylroie, H., Dumont, O., Bauer, A., Thornton, C. C., Mackey, J., Calay, D., Hamdulay, S. S., Choo, J. R., Boyle, J. J., Samarel, A. M., Randi, A. M., Evans, P. C., Mason, J. C. Tags: Vascular biology Source Type: research