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Total 1410 results found since Jan 2013.
Extracellular sulfatase-2 is overexpressed in rheumatoid arthritis and mediates the TNF- α-induced inflammatory activation of synovial fibroblasts
This study identified a novel role of Sulf-2 in TNF-α signaling and the activation of RA synoviocytes, providing the rationale for evaluating the therapeutic targeting of Sulf-2 in preclinical models of RA.PMID:36068294 | DOI:10.1038/s41423-022-00913-x
Source: Cellular and Molecular Immunology - September 6, 2022 Category: Molecular Biology Authors: Ruby J Siegel Anil K Singh Paul M Panipinto Farheen S Shaikh Judy Vinh Sang U Han H Mark Kenney Edward M Schwarz Cynthia S Crowson Sadik A Khuder Basil S Khuder David A Fox Salahuddin Ahmed Source Type: research
P2X7 Receptor-Induced Bone Cancer Pain by Regulating Microglial Activity via NLRP3/IL-1beta Signaling
CONCLUSION: These findings suggest that targeting the microglial P2X7R activated NLRP3/IL-1beta signaling pathway could serve as a potential strategy for BCP treatment.PMID:36375190
Source: Pain Physician - November 14, 2022 Category: Anesthesiology Authors: Ping Wu Xiaoqi Wu Guohua Zhou Yin Wang Xiaojun Liu Run Lv YanSong Liu Qingping Wen Source Type: research
AMPK boosts ADAM10 shedding activity in human aortic endothelial cells by promoting Rab14-dependent ADAM10 cell surface translocation
In conclusion, AMPK activation is an obvious inducer of ADAM10 shedding activity. Our findings suggest that AMPK boosts ADAM10 shedding activity in HAECs by promoting Rab14-dependent ADAM10 cell surface translocation.PMID:37451218 | DOI:10.1016/j.bbrc.2023.07.010
Source: Biochemical and Biophysical Research communications - July 14, 2023 Category: Biochemistry Authors: Chung Hee Baek Hyosang Kim Soo Young Moon Won Seok Yang Source Type: research
Fine particulate matter promotes airway inflammation and mucin production by activating endoplasmic reticulum stress and the IRE1 α/NOD1/NF‑κB pathway
Int J Mol Med. 2023 Oct;52(4):96. doi: 10.3892/ijmm.2023.5299. Epub 2023 Sep 1.ABSTRACTFine particulate matter (PM2.5) is a type of small particle that is <2.5 µm in diameter that may cause airway inflammation. Thus, the present study aimed to explore the effects of PM2.5 on endoplasmic reticulum (ER) stress and airway inflammation in human airway epithelial cells. For this purpose, HBE135‑E6E7 airway epithelial cells were cultured and exposed to specific concentrations of PM2.5 for various periods of time, and cell viability was determined using a Cell Counting Kit‑8 assay. The results of the present study demonst...
Source: International Journal of Molecular Medicine - September 1, 2023 Category: Molecular Biology Authors: Lihua Hu Chaoqun Xu Xiang Tang Shanjun Yu Lijun Wang Qi Li Xiangdong Zhou Source Type: research
Nicotine Induced Epithelial-Mesenchymal Transition via Wnt/β-catenin Signaling in Human Airway Epithelial Cells.
Conclusion: These results suggest that HBECs are able to undergo EMT in vitro upon nicotine stimulation via the Wnt3a/β-catenin signaling pathway.
PMID: 23204070 [PubMed - as supplied by publisher]
Source: American Journal of Physiology. Lung Cellular and Molecular Physiology - November 30, 2012 Category: Cytology Authors: Zou W, Zou Y, Zhao Z, Li B, Ran P Tags: Am J Physiol Lung Cell Mol Physiol Source Type: research
Apoptotic effect of dibenzylideneacetone on oral cancer cells via modulation of specificity protein 1 and Bax
ConclusionThese findings suggest that DBA may be a potential anticancer drug candidate to induce apoptosis through down‐regulation of Sp1 in human oral cancer.
Source: Oral Diseases - January 11, 2013 Category: ENT & OMF Authors: H‐J Yu, J‐A Shin, J‐S Nam, B S Kang, S‐D Cho Tags: Original Article Source Type: research
Klebsiella pneumoniae targets an EGF receptor‐dependent pathway to subvert inflammation.
Abstract
The NF‐κB transcriptional factor plays a key role governing the activation of immune responses. Klebsiella pneumoniae is an important cause of community‐acquired and nosocomial pneumonia. Evidence indicates that K. pneumoniae infections are characterized by lacking an early inflammatory response. Recently, we have demonstrated that Klebsiella antagonizes the activation of NF‐κB via the deubiquitinase CYLD. In this work, by applying a high‐throughput siRNA gain‐on‐function screen interrogating the human kinome, we identified 17 kinases that when targeted by siRNA restored IL‐1β‐dependent NF‐κB...
Source: Cellular Microbiology - January 25, 2013 Category: Microbiology Authors: Christian G. Frank, Verónica Reguerio, Marion Rother, David Moranta, André P. Maeurer, Junkal Garmendia, Thomas F. Meyer, José A. Bengoechea Tags: Research Article Source Type: research
