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Condition: Dermatitis

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Total 92 results found since Jan 2013.

Anti-RelA siRNA-Encapsulated Flexible Liposome with Tight Junction-Opening Peptide as a Non-invasive Topical Therapeutic for Atopic Dermatitis.
Abstract Small interfering RNA (siRNA) has been proposed as a novel treatment for atopic dermatitis (AD) because it suppresses sequence-specific mRNA expression. Indeed siRNA-based therapy achieves an almost complete cure with fewer side effects than currently available treatments. However, the tight junctions in the granular layer of the epidermis in the atopic skin are barriers to siRNA delivery. We previously reported the potential clinical utility of AT1002, a peptide that opens tight junctions. In the present study, we evaluated a topical siRNA-based therapy for AD using AT1002 in combination with a flexible ...
Source: Biological and Pharmaceutical Bulletin - July 3, 2019 Category: Drugs & Pharmacology Authors: Ibaraki H, Kanazawa T, Kurano T, Oogi C, Takashima Y, Seta Y Tags: Biol Pharm Bull Source Type: research

Contact allergen (PPD and DNCB)-induced keratinocyte sensitization is partly mediated through a low molecular weight hyaluronan (LMWHA)/TLR4/NF- κB signaling axis.
In conclusion, keratinocyte contact allergen-dependent sensitization is partly mediated through a LMWHA/TLR4/ NF-κB signaling axis. PMID: 31226360 [PubMed - as supplied by publisher]
Source: Toxicology and Applied Pharmacology - June 17, 2019 Category: Toxicology Authors: Kavasi RM, Berdiaki A, Spyridaki I, Papoutsidakis A, Corsini E, Tsatsakis A, Tzanakakis G, Dragana N Tags: Toxicol Appl Pharmacol Source Type: research

Involvement of α-Melanocyte-Stimulating Hormone-Thromboxane A2 System on Itching in Atopic Dermatitis.
Abstract α-Melanocyte-stimulating hormone (α-MSH) is an endogenous peptide hormone involved in cutaneous pigmentation in atopic dermatitis (AD) with severe itching. α-MSH elicits itch-related responses in mice. We therefore investigated whether α-MSH was involved in itching in AD. In the skin of AD patients and mice with atopy-like dermatitis, α-MSH and the prohormone convertase 2, which is the key processing enzyme for the production of α-MSH, were distributed mainly in keratinocytes. In the skin of mice with dermatitis, α-MSH receptors (MC1R and MC5R) were expressed at the mRNA level and were distributed ...
Source: The American Journal of Pathology - June 16, 2019 Category: Pathology Authors: Andoh T, Akasaka C, Shimizu K, Lee JB, Yoshihisa Y, Shimizu T Tags: Am J Pathol Source Type: research

Current non-viral siRNA delivery systems as a promissing treatment of skin diseases.
CONCLUSION: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin. PMID: 30084329 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 7, 2018 Category: Drugs & Pharmacology Authors: Rosa J, Suzuki I, Kravicz M, Caron A, Pupo AV, Praca FG, Bentley MVLB Tags: Curr Pharm Des Source Type: research

894 Poly(I:C) and GAG inhibit exogenous HSV1 infection in the barrier dysfunctional 3D epidermal model
Skin barrier dysfunction often induces severe herpes simplex virus (HSV) infection that is known as Kaposi's varicelliform eruption (KVE). KVE often occurs on patients with atopic dermatitis or genetic skin disease such as Dariers disease (DD). The mechanism of KVE has not been clearly proved, and the preventive methods have not been found. We previously established a skin barrier dysfunctional 3D model using siRNA of ATP2A2 of which gene mutation is confirmed in DD. This 3D model has dyskeratosis and TEM observation clearly revealed epidermal cleft that is caused by the absence of desmosome at intercellular space in ATP2A...
Source: Journal of Investigative Dermatology - April 27, 2018 Category: Dermatology Authors: E. Sato, K. Hiromatsu, K. Murata, S. Imafuku Tags: Innate Immunity, Microbiology, Inflammation Source Type: research

Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models
ConclusionsThe fractional laser was valid for ameliorating macromolecule permeation into barrier-disrupted skin although the enhancement level was lower than that of normal skin.
Source: Pharmaceutical Research - April 26, 2018 Category: Drugs & Pharmacology Source Type: research

894 Poly(I:C) and GAG inhibit exogenous HSV1 infection in the barrier dysfunctional 3D epidermal model
Skin barrier dysfunction often induces severe herpes simplex virus (HSV) infection that is known as Kaposi's varicelliform eruption (KVE). KVE often occurs on patients with atopic dermatitis or genetic skin disease such as Dariers disease (DD). The mechanism of KVE has not been clearly proved, and the preventive methods have not been found. We previously established a skin barrier dysfunctional 3D model using siRNA of ATP2A2 of which gene mutation is confirmed in DD. This 3D model has dyskeratosis and TEM observation clearly revealed epidermal cleft that is caused by the absence of desmosome at intercellular space in ATP2A...
Source: Journal of Investigative Dermatology - April 19, 2018 Category: Dermatology Authors: E. Sato, K. Hiromatsu, K. Murata, S. Imafuku Tags: Innate Immunity, Microbiology, Inflammation Source Type: research

PCV2 infection aggravates ochratoxin A-induced nephrotoxicity via autophagy involving p38 signaling pathway in  vivo and in vitro.
PCV2 infection aggravates ochratoxin A-induced nephrotoxicity via autophagy involving p38 signaling pathway in vivo and in vitro. Environ Pollut. 2018 Mar 31;238:656-662 Authors: Gan F, Zhou Y, Qian G, Huang D, Hou L, Liu D, Chen X, Wang T, Jiang P, Lei X, Huang K Abstract Ochratoxin A (OTA) is reported to induce nephrotoxicity in animals and humans. Porcine circovirus type 2 (PCV2) could induce porcine dermatitis and nephropathy syndrome. To date, little is known whether virus infection aggravates mycotoxin-induced toxicity. This work aimed to study the effects of PCV2 infection on OTA-induced neph...
Source: Environmental Pollution - March 31, 2018 Category: Environmental Health Authors: Gan F, Zhou Y, Qian G, Huang D, Hou L, Liu D, Chen X, Wang T, Jiang P, Lei X, Huang K Tags: Environ Pollut Source Type: research

Transdermal anti-nuclear kappaB siRNA therapy for atopic dermatitis using a combination of two kinds of functional oligopeptide
Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1–2 Author(s): Hisako Ibaraki, Takanori Kanazawa, Yuuki Takashima, Hiroaki Okada, Yasuo Seta Nucleic acid-based targeting of nuclear factor kappaB (NF-κB) is gaining attention as a treatment option for skin diseases like atopic dermatitis (AD). Transdermal administration improves patient quality of life because of non-invasive; however, siRNA delivery into the skin can be challenging owing to the barrier of tight junctions in the granular layer. Therefore, we aimed to develop a delivery system of siRNA for topical skin applic...
Source: International Journal of Pharmaceutics - March 23, 2018 Category: Drugs & Pharmacology Source Type: research

IL ‐26 in allergic contact dermatitis: resource in a state of readiness
In conclusion, our findings support the idea that this emergent cytokine, IL‐26, is implicated in the killing mechanisms of KC observed during ACD. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - March 2, 2018 Category: Dermatology Authors: Giuseppina Caiazzo, Roberta Di Caprio, Serena Lembo, Annunziata Raimondo, Emanuele Scala, Cataldo Patruno, Anna Balato Tags: Methods Letter to the Editors Source Type: research

Intra-articular Retention and Anti-arthritic Effects in Collagen-Induced Arthritis Model Mice by Injectable Small Interfering RNA Containing Hydrogel.
In this study, to develop an intra-articular injectable gel formulation against RA, we prepared a hydrogel that contains anti-RelA siRNA, and determined the in vitro release profile (%) and in vivo intra-articular retention of fluorescence-labeled model siRNA, and the anti-arthritic effects of the anti-RelA siRelA containing hydrogel in RA model mice. We selected the silk protein, sericin (SC), as an aqueous gel base, as it is a biocompatible and useful for forming hydrogels without a cross-linker. We showed that fluorescence-labeled model siRNA was continuously released from SC hydrogel in vitro, and retained in the knee ...
Source: Biological and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Kanazawa T, Tamano K, Sogabe K, Endo T, Ibaraki H, Takashima Y, Seta Y Tags: Biol Pharm Bull Source Type: research

Regulation of claudin ‐4 via p63 in human epithelial cells
P63 is a regulator of cell–cell junction complexes in the epidermis. Claudin‐4 is regulated via various factors in normal epithelial cells and diseases. We found that claudin‐4 was directly regulated via p63 (TAp63 and ΔNp63) in human keratinocytes and nasal epithelial cells. In the epidermis of atopic dermatitis (AD), which contains ΔNp63‐deficient keratinocytes, high expression of claudin‐4 was observed. In primary keratinocytes, downregulation of ΔNp63 by treatment with short interfering RNA (siRNA)‐p63 induced claudin‐4 expression. In nasal epithelial cells in the context of rhinitis or nasal polyps, u...
Source: Annals of the New York Academy of Sciences - July 1, 2017 Category: Science Authors: Takashi Kojima, Takayuki Kohno, Terufumi Kubo, Yakuto Kaneko, Takuya Kakuki, Akito Kakiuchi, Makoto Kurose, Ken ‐ichi Takano, Noriko Ogasawara, Kazufumi Obata, Kazuaki Nomura, Ryo Miyata, Takumi Konno, Shingo Ichimiya, Tetsuo Himi Tags: REVIEW Source Type: research

Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions
This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation. Mice were sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. The initial stage of AD model, in which mice were just sensitized with FITC, was established in vivo and immortalized human epidermal (HaCaT) cells were utilized in vitro. Initiative key cytokines, TSLP and IL‐33, were measured by ELISA, the junctions in ECs were observed by electron microscopy and TJs (CLDN‐1, occludin and CLDND1) were assessed by Western blot, immunohistochemistry and immunofluorescence. The results show...
Source: Journal of Cellular and Molecular Medicine - June 9, 2017 Category: Molecular Biology Authors: Xiaoyu Wang, Xiaoyan Jiang, Xi Yu, Hailiang Liu, Yu Tao, Guorong Jiang, Min Hong Tags: Original Article Source Type: research

Cimifugin suppresses allergic inflammation by reducing epithelial derived initiative key factors via regulating tight junctions.
This study aims to determine the mechanism of cimifugin on epithelial cells in allergic inflammation. Mice were sensitized and challenged with FITC to establish type 2 atopic dermatitis (AD) model. The initial stage of AD model, in which mice were just sensitized with FITC, was established in vivo and immortalized human epidermal (HaCaT) cells were utilized in vitro. Initiative key cytokines, TSLP and IL-33, were measured by ELISA, the junctions in ECs were observed by electron microscopy and TJs (CLDN-1, occludin and CLDND1) were assessed by Western blot, immunohistochemistry and immunofluorescence. The results showed t...
Source: J Cell Mol Med - June 9, 2017 Category: Molecular Biology Authors: Wang X, Jiang X, Yu X, Liu H, Tao Y, Jiang G, Hong M Tags: J Cell Mol Med Source Type: research

Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease < i > In Vivo < /i >
ConclusionsOur findings may point to a novel role for filaggrin in early antiviral responses in skin. In wounded skin with underlying barrier defects, chronically elevated activin A levels may contribute to skin remodeling and cutaneous pathogen persistence. Inhibition of ALK5/TGF βR1 signaling may provide a novel co-therapeutic approach, together with VIG, to limit cutaneous spread of vaccinia.
Source: PLoS One - January 11, 2017 Category: Biomedical Science Authors: Yong He Source Type: research