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Condition: Dermatitis

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Total 92 results found since Jan 2013.

Srb1 as a new redox target of cigarette smoke in human sebocytes.
In conclusion, exposure to CS, induced SRB1 post-translational modifications in sebocytes and this might affect sebocytes/skin functionality. PMID: 27865981 [PubMed - as supplied by publisher]
Source: Free Radical Biology and Medicine - November 15, 2016 Category: Biology Authors: Crivellari I, Sticozzi C, Belmonte G, Muresan XM, Cervellati F, Pecorelli A, Cavicchio C, Maioli E, Zouboulis CC, Benedusi M, Cervellati C, Valacchi G Tags: Free Radic Biol Med Source Type: research

Molecules, Vol. 21, Pages 1279: Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide
In this study, we examined intradermal siRNA permeability in the tape-stripped (20 times) back skin of mice or AD-like skin of auricles treated with 6-carboxyfluorescein-aminohexyl phosphoramidite (F AM)-labeled siRNA, the tight junction modulator AT1002, and the functional cytoplasm-responsive stearylated peptide STR-CH2R4H2C by using confocal laser microscopy. We found that strong fluorescence was observed deep and wide in the epidermis and dermis of back skin and AD-like ears after siRNA with STR-CH2R4H2C and AT1002 treatment. After 10 h from administration, brightness of FAM-siRNA was significantly higher for STR-CH2R4...
Source: Molecules - September 23, 2016 Category: Chemistry Authors: Hisako Ibaraki Takanori Kanazawa Yuuki Takashima Hiroaki Okada Yasuo Seta Tags: Article Source Type: research

Toluene induces early growth response-1 dependent thymic stromal lymphopoietin expression in human keratinocytes
AbstractVolatile organic compounds (VOCs) can be an important environmental risk factor in the development and/or aggravation of atopic dermatitis (AD). In a several studies to evaluate the clinical effects of air pollution including VOCs on skin symptoms in AD patients. Although these accumulated data shows an association between exposure to VOCs and aggravation of AD, the molecular effects of VOCs on the aggravation of AD is still not clear. The present study demonstrates increases of thymic stromal lymphopoietin (TSLP) in keratinocytes following exposure to toluene. We further investigated the regulatory mechanisms of t...
Source: Molecular and Cellular Toxicology - August 31, 2016 Category: Cytology Source Type: research

Chloroform upregulates early growth response‐1‐dependent thymic stromal lymphopoietin expression via the JNK and ERK pathways in human keratinocytes
ConclusionsTaken together, these findings suggest that, in human keratinocytes, the upregulation of TSLP by chloroform is induced through an Egr‐1‐dependent mechanism that requires the c‐JNK and ERK pathways. Our results suggest that exposure to chloroform may aggravate allergic skin diseases such as AD through Egr‐1‐dependent TSLP regulation.
Source: International Journal of Dermatology - October 16, 2015 Category: Dermatology Authors: Hana Lee, Hyun Cheol Bae, Jinhee Kim, Sang Hoon Jeong, Woo‐In Ryu, Sang Wook Son Tags: Report Source Type: research

2,3-Dimethoxy-2'-hydroxychalcone ameliorates TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness via NF-kappaB inhibition and HO-1 induction in HaCaT cells.
In this study, we investigated the modulatory effects of 2,3-dimethoxy-2'-hydroxychalcone (DMHC) on tumor necrosis factor (TNF)-α-induced intercellular adhesion molecule-1 (ICAM-1) expression and monocyte adhesiveness, as well as the molecular mechanisms underlying its action in the HaCaT human keratinocyte cell line. Pre-treating HaCaT cells with DMHC significantly suppressed TNF-α-induced ICAM-1 expression and subsequent monocyte adhesiveness. DMHC inhibited TNF-α-induced activation of NF-κB. In addition, DMHC induced HO-1 expression as well as NRF2 activation. Furthermore, HO-1 knockdown using siRNA reversed the inh...
Source: BMB Reports - August 14, 2015 Category: Biochemistry Authors: Kim H, Youn GS, An SY, Kwon HY, Choi SY, Park J Tags: BMB Rep Source Type: research

Functional peptide nanocarriers for delivery of novel anti-RelA RNA interference agents as a topical treatment of atopic dermatitis
Publication date: 15 July 2015 Source:International Journal of Pharmaceutics, Volume 489, Issues 1–2 Author(s): Takanori Kanazawa , Tomohiro Hamasaki , Takahiro Endo , Kuniko Tamano , Kana Sogabe , Yasuo Seta , Tadaaki Ohgi , Hiroaki Okada Small interfering RNAs (siRNAs) are a potential treatment of atopic dermatitis (AD) because they can specifically silence the gene expression of AD-related factors. However, siRNA alone cannot exert a sufficiently strong therapeutic effect due to low delivery efficiency to the target tissues and cells; simply increasing the amount used is not possible due to the possibility of off-ta...
Source: International Journal of Pharmaceutics - May 15, 2015 Category: Drugs & Pharmacology Source Type: research

Ochratoxin A promotes porcine circovirus type 2 replication in vitro and in vivo.
Abstract Ochratoxin A (OTA), a worldwide mycotoxin found in food and feeds, is a potent nephrotoxin in animals and humans. Porcine circovirus-associated disease (PCVAD), including porcine dermatitis and nephropathy syndrome, is a worldwide swine disease. To date, little is known concerning the relationship between OTA and porcine circovirus type 2 (PCV2), the primary causative agent of PCVAD. Effects of OTA on PCV2 replication and its mechanism were investigated in vitro and in vivo. The results in vitro showed that low doses of OTA significantly increased PCV2 DNA copies and the number of infected cells. Maximum ...
Source: Free Radical Biology and Medicine - December 23, 2014 Category: Biology Authors: Gan F, Zhang Z, Hu Z, Hesketh J, Xue H, Chen X, Hao S, Huang Y, Cole Ezea P, Parveen F, Huang K Tags: Free Radic Biol Med Source Type: research

ZIP2 Is Associated with Keratinocyte Differentiation Gene Regulation
Zinc is essential for the proper functioning of various enzymes and transcription factors, and its homeostasis is rigorously controlled by zinc transporters (SLC39/ZIP, importers; SLC30/ZnT, exporters). Skin disease is commonly caused by a zinc deficiency. Dietary and inherited zinc deficiencies are known to cause alopecia and the development of vesicular or pustular dermatitis. A previous study demonstrated that zinc played crucial roles in the survival of keratinocytes and their unique functions. High levels of zinc have been detected in the epidermis. Epidermal layers are considered to use a mechanism that preferentiall...
Source: Journal of Biological Chemistry - July 31, 2014 Category: Chemistry Authors: Inoue, Y., Hasegawa, S., Ban, S., Yamada, T., Date, Y., Mizutani, H., Nakata, S., Tanaka, M., Hirashima, N. Tags: Cell Biology Source Type: research

Quercetagetin inhibits macrophage derived chemokine (MDC), a skin inflammatory chemokine, via the regulation of STAT1, SOCS1, and TGF‐β1 in HaCaT human keratinocytes
ConclusionsThese results suggest that quercetagetin may be the potent inhibitor on STAT1 signal, potentially be claimed as a new molecular target for anti‐inflammation treatment, and may thus have therapeutic applications as an immune modulator in inflammatory diseases such as AD.This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - March 6, 2014 Category: Dermatology Authors: G.‐J. Kang, S.‐C. Han, N.‐J. Kang, D.‐H Koo, D.‐B. Park, S.‐Y. Eun, H.‐K. Kang, E.‐S. Yoo Tags: Clinical and laboratory investigations Source Type: research

Interleukin-37.
Abstract IL-37 was formerly termed IL-1 family member 7. The cytokine was discovered by in silico research of human databases. Although there are no genes in the databases with an open reading frame for a murine homologue for IL-37, human IL-37 is functional in the mouse. Like others members of the IL-1 family, IL-37 lacks a signal peptide. The precursor form of IL-37 has a caspase-1 site, but the role of caspase-1 in the processing and secretion of IL-37 has not been documented with certainty. IL-37 is similar to IL-1β and IL-33, in that the cytokine is found in the nucleus where, like IL-1β and IL-33, function...
Source: Seminars in Immunology - November 22, 2013 Category: Allergy & Immunology Authors: Dinarello CA, Bufler P Tags: Semin Immunol Source Type: research

Expressions of peroxisome proliferator‐activated receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD.
Source: Experimental Dermatology - August 16, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Expressions of PPARs are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes
In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD. This article is protected by copyright. All rights reserved.
Source: Experimental Dermatology - June 29, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research

Coal tar induces AHR-dependent skin barrier repair in atopic dermatitis
Topical application of coal tar is one of the oldest therapies for atopic dermatitis (AD), a T helper 2 (Th2) lymphocyte–mediated skin disease associated with loss-of-function mutations in the skin barrier gene, filaggrin (FLG). Despite its longstanding clinical use and efficacy, the molecular mechanism of coal tar therapy is unknown. Using organotypic skin models with primary keratinocytes from AD patients and controls, we found that coal tar activated the aryl hydrocarbon receptor (AHR), resulting in induction of epidermal differentiation. AHR knockdown by siRNA completely abrogated this effect. Coal tar restored ...
Source: Journal of Clinical Investigation - January 26, 2013 Category: Biomedical Science Authors: Ellen H. van den Bogaard, Judith G.M. Bergboer, Mieke Vonk-Bergers, Ivonne M.J.J. van Vlijmen-Willems, Stanleyson V. Hato, Pieter G.M. van der Valk, Jens Michael Schröder, Irma Joosten, Patrick L.J.M. Zeeuwen, Joost Schalkwijk Source Type: research

Identification of a novel receptor for S100A8 and its possible involvement in abnormal proliferation
Although S100A8 and S100A9 are suggested to play important roles in inflammation, molecular mechanisms are still obscure. Previously we reported that S100A9 induced inflammatory cytokines including IL-8 and TNFα and S100A8 promoted proliferation in cultured keratinocytes. Using LC/MS/MS analysis we identified matrix metalloproteinase inducer (EMMPRIN) as a specific receptor for S100A9. In the present study, we tried to find a receptor for S100A8. Database search based on the similarity with EMMPRIN identified neuroplastin (NPTN) as a candidate molecule. We confirmed that NPTN was bound with S100A8 by immunoprecipitation a...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Mami Yamamoto, Masakiyo Sakaguchi, Akira Motoyama, Nam-ho Huh, Ryoji Tsuboi, Toshihiko Hibino Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Regulation of IL-33 expression by inflammatory cytokines and its putative role in inflammatory skin disorders
Interleukin (IL)-33, a member of the IL-1 family, has been implicated in Th2 immune reactions. We investigated the effect of Th-1, Th-2 and Th-17 cytokines on IL-33 expression in normal human epidermal keratinocytes (NHEKs).IFN-γ, IL-4, and IL-17A dose- and time-dependently induced IL-33 expression; this was dependent on extracellular signal-regulated kinase (ERK), p38, and epidermal growth factor receptor (EGFR) phosphorylation. We found that the inhibition of signal transducer and activator of transcription (STAT) 3, but not that of STAT1, suppressed the induction of IL-33 expression by IFN-γor IL-17A. TNF-α had no ef...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Jitlada Meephansan, Mayumi Komine, Hidetoshi Tsuda, Tomoyuki Oshio, Masaru Karakawa, Shin-ichi Tominaga, Mamitaro Ohtsuki Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research