Expressions of peroxisome proliferator‐activated receptors (PPARs) are directly influenced by permeability barrier abrogation and inflammatory cytokines and depressed PPARα modulates expressions of chemokines and epidermal differentiation‐related molecules in keratinocytes

In conclusion, depressed PPARα in keratinocytes might be involved in a relationship between permeability barrier abrogation and allergic inflammation and could be a therapeutic target which accounts for both the aspects in AD.

http://onlinelibrary.wiley.com/resolve/doi?DOI=10.1111%2Fexd.12208

Source: Experimental Dermatology - August 16, 2013 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Letter to the Editor Source Type: research