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Condition: Dermatitis
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Total 92 results found since Jan 2013.
Phospholipase Cδ1 is required for normal expression of profilaggrin in keratinocytes
Phospholipase C (PLC) is a key enzyme in phosphoinositide turnover. Since one of PLC isozymes, PLCδ1 is abundantly expressed in epidermis, we examined expression patterns of differentiation markers in epidermis of mice lacking PLCδ1 (PLCδ1 KO mice). Immunofluorescence revealed that the expression pattern of filaggrin was disturbed in epidermis of PLCδ1 KO mice. siRNA-mediated knockdown of PLCδ1 decreased profilaggrin mRNA in HaCaT cells and normal human keratinocytes. In addition, overexpression of PLCδ1 resulted in significant increase in profilaggrin mRNA in HaCaT cells. Loss-of-function mutations of filaggrin are ...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yoshikazu Nakamura, Kaori Kanemaru, Kenji Kabashima, Kyoko Nakahigashi, Kiyoko Fukami Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research
Depressed PPARα accelerates a vicious cycle between allergic inflammation and barrier dysfunction
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and are of three subtypes: PPARα, PPARβ/δ and PPARγ. Activation of PPARs not only has positive effects on permeability barrier homeostasis but also has anti-inflammatory effects. Reduced expression of PPARα in lesional skin in atopic dermatitis (AD) and the preventive and therapeutic effects of a synthetic ligand for PPARα on AD-like dermatitis in a hapten-induced model of AD in mice have been demonstrated. Epidermal levels of expression of PPARα but of neither PPARβ/δ nor PPARγ were reduced in mice with hapten-induced AD. Expressio...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research
