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Condition: Dermatitis

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Total 92 results found since Jan 2013.

Anti-RelA siRNA-Encapsulated Flexible Liposome with Tight Junction-Opening Peptide as a Non-invasive Topical Therapeutic for Atopic Dermatitis.
Abstract Small interfering RNA (siRNA) has been proposed as a novel treatment for atopic dermatitis (AD) because it suppresses sequence-specific mRNA expression. Indeed siRNA-based therapy achieves an almost complete cure with fewer side effects than currently available treatments. However, the tight junctions in the granular layer of the epidermis in the atopic skin are barriers to siRNA delivery. We previously reported the potential clinical utility of AT1002, a peptide that opens tight junctions. In the present study, we evaluated a topical siRNA-based therapy for AD using AT1002 in combination with a flexible ...
Source: Biological and Pharmaceutical Bulletin - July 3, 2019 Category: Drugs & Pharmacology Authors: Ibaraki H, Kanazawa T, Kurano T, Oogi C, Takashima Y, Seta Y Tags: Biol Pharm Bull Source Type: research

Molecules, Vol. 21, Pages 1279: Development of an Innovative Intradermal siRNA Delivery System Using a Combination of a Functional Stearylated Cytoplasm-Responsive Peptide and a Tight Junction-Opening Peptide
In this study, we examined intradermal siRNA permeability in the tape-stripped (20 times) back skin of mice or AD-like skin of auricles treated with 6-carboxyfluorescein-aminohexyl phosphoramidite (F AM)-labeled siRNA, the tight junction modulator AT1002, and the functional cytoplasm-responsive stearylated peptide STR-CH2R4H2C by using confocal laser microscopy. We found that strong fluorescence was observed deep and wide in the epidermis and dermis of back skin and AD-like ears after siRNA with STR-CH2R4H2C and AT1002 treatment. After 10 h from administration, brightness of FAM-siRNA was significantly higher for STR-CH2R4...
Source: Molecules - September 23, 2016 Category: Chemistry Authors: Hisako Ibaraki Takanori Kanazawa Yuuki Takashima Hiroaki Okada Yasuo Seta Tags: Article Source Type: research

Transdermal anti-nuclear kappaB siRNA therapy for atopic dermatitis using a combination of two kinds of functional oligopeptide
Publication date: 5 May 2018 Source:International Journal of Pharmaceutics, Volume 542, Issues 1–2 Author(s): Hisako Ibaraki, Takanori Kanazawa, Yuuki Takashima, Hiroaki Okada, Yasuo Seta Nucleic acid-based targeting of nuclear factor kappaB (NF-κB) is gaining attention as a treatment option for skin diseases like atopic dermatitis (AD). Transdermal administration improves patient quality of life because of non-invasive; however, siRNA delivery into the skin can be challenging owing to the barrier of tight junctions in the granular layer. Therefore, we aimed to develop a delivery system of siRNA for topical skin applic...
Source: International Journal of Pharmaceutics - March 23, 2018 Category: Drugs & Pharmacology Source Type: research

Current non-viral siRNA delivery systems as a promissing treatment of skin diseases.
CONCLUSION: The treatment of skin diseases based on topical delivery of siRNA, which act by inhibiting the expression of target transcripts, offers many potential therapeutic advantages for suppressing genes into the skin. PMID: 30084329 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 7, 2018 Category: Drugs & Pharmacology Authors: Rosa J, Suzuki I, Kravicz M, Caron A, Pupo AV, Praca FG, Bentley MVLB Tags: Curr Pharm Des Source Type: research

Small interfering RNA targeting of keratin 17 reduces inflammation in imiquimod-induced psoriasis-like dermatitis.
CONCLUSIONS: Inhibition of K17 expression by its specific siRNA significantly alleviated inflammation in mice with IMQ-induced psoriasis-like dermatitis. Thus, gene therapy targeting K17 may be a potential treatment approach for psoriasis. PMID: 33237695 [PubMed - as supplied by publisher]
Source: Chinese Medical Journal - November 20, 2020 Category: General Medicine Authors: Xiao CY, Zhu ZL, Zhang C, Fu M, Qiao HJ, Wang G, Dang EL Tags: Chin Med J (Engl) Source Type: research

Intra-articular Retention and Anti-arthritic Effects in Collagen-Induced Arthritis Model Mice by Injectable Small Interfering RNA Containing Hydrogel.
In this study, to develop an intra-articular injectable gel formulation against RA, we prepared a hydrogel that contains anti-RelA siRNA, and determined the in vitro release profile (%) and in vivo intra-articular retention of fluorescence-labeled model siRNA, and the anti-arthritic effects of the anti-RelA siRelA containing hydrogel in RA model mice. We selected the silk protein, sericin (SC), as an aqueous gel base, as it is a biocompatible and useful for forming hydrogels without a cross-linker. We showed that fluorescence-labeled model siRNA was continuously released from SC hydrogel in vitro, and retained in the knee ...
Source: Biological and Pharmaceutical Bulletin - November 4, 2017 Category: Drugs & Pharmacology Authors: Kanazawa T, Tamano K, Sogabe K, Endo T, Ibaraki H, Takashima Y, Seta Y Tags: Biol Pharm Bull Source Type: research

Depressed PPARα accelerates a vicious cycle between allergic inflammation and barrier dysfunction
Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors and are of three subtypes: PPARα, PPARβ/δ and PPARγ. Activation of PPARs not only has positive effects on permeability barrier homeostasis but also has anti-inflammatory effects. Reduced expression of PPARα in lesional skin in atopic dermatitis (AD) and the preventive and therapeutic effects of a synthetic ligand for PPARα on AD-like dermatitis in a hapten-induced model of AD in mice have been demonstrated. Epidermal levels of expression of PPARα but of neither PPARβ/δ nor PPARγ were reduced in mice with hapten-induced AD. Expressio...
Source: Journal of Dermatological Science - December 20, 2012 Category: Dermatology Authors: Yasuko Adachi, Yutaka Hatano, Takashi Sakai, Sakuhei Fujiwara Tags: Abstracts from the 37th Annual Meeting of the Japanese Society for Investigative Dermatology Source Type: research

Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease < i > In Vivo < /i >
ConclusionsOur findings may point to a novel role for filaggrin in early antiviral responses in skin. In wounded skin with underlying barrier defects, chronically elevated activin A levels may contribute to skin remodeling and cutaneous pathogen persistence. Inhibition of ALK5/TGF βR1 signaling may provide a novel co-therapeutic approach, together with VIG, to limit cutaneous spread of vaccinia.
Source: PLoS One - January 11, 2017 Category: Biomedical Science Authors: Yong He Source Type: research

Is the Fractional Laser Still Effective in Assisting Cutaneous Macromolecule Delivery in Barrier-Deficient Skin? Psoriasis and Atopic Dermatitis as the Disease Models
ConclusionsThe fractional laser was valid for ameliorating macromolecule permeation into barrier-disrupted skin although the enhancement level was lower than that of normal skin.
Source: Pharmaceutical Research - April 26, 2018 Category: Drugs & Pharmacology Source Type: research

TGF ‐β secreted by human umbilical cord blood‐derived mesenchymal stem cells ameliorates atopic dermatitis by inhibiting secretion of TNF‐α and IgE
This study investigated the role of transforming growth factor‐beta (TGF‐β) in the therapeutic effect of hUCB‐MSCs on AD. Small interfering RNA (siRNA)‐ mediated depletion of TGF‐β disrupted the therapeutic effect of hUCB‐MSCs in a mouse model of AD by attenuating the beneficial changes in histopathology, mast cell infiltration, tumor necrosis factor ‐alpha (TNF ‐α) expression, and the serum IgE level. To confirm that hUCB‐MSCs regulate secretion of TNF‐α, we investigated whether they inhibit TNF‐α secretion by activated LAD2 cells. Coculture with hUCB‐MSCs significantly inhibited secretion of ...
Source: Stem Cells - April 10, 2020 Category: Stem Cells Authors: Hwanhee Park, Seunghee Lee, Yeonsil Yu, SaeMi Yoo, Song Yi Baek, Namhee Jung, Kwang ‐Won Seo, Kyung‐Sun Kang Tags: Translational and Clinical Research Source Type: research

The Role of Collagen VI α6 Chain Gene in Atopic Dermatitis
CONCLUSION: The reduction of epidermal COL6A6 due to the genetic mutation can cause skin barrier damage and it can contributes to the early onset of AD. COL6A6 is induced by IL-4 and IL-13, and it may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD.PMID:35221595 | PMC:PMC8831303 | DOI:10.5021/ad.2022.34.1.46
Source: Annals of Dermatology - February 28, 2022 Category: Dermatology Authors: Hye Jung Jung Won Il Heo Kui Young Park Mi-Kyung Lee Ji Young Ahn Mi Youn Park Seong Jun Seo Source Type: research