Cutaneous Deficiency of Filaggrin and STAT3 Exacerbates Vaccinia Disease < i > In Vivo < /i >

ConclusionsOur findings may point to a novel role for filaggrin in early antiviral responses in skin. In wounded skin with underlying barrier defects, chronically elevated activin A levels may contribute to skin remodeling and cutaneous pathogen persistence. Inhibition of ALK5/TGF βR1 signaling may provide a novel co-therapeutic approach, together with VIG, to limit cutaneous spread of vaccinia.

Source: PLoS One - January 11, 2017 Category: Biomedical Science Authors: Yong He Source Type: research