Filtered By:
Condition: Dermatitis
This page shows you your search results in order of date.
Order by Relevance | Date
Total 92 results found since Jan 2013.
TNF- α promotes CXCL-1/8 production in keratinocytes by downregulating galectin-3 through NF-κB and hsa-miR-27a-3p pathway to contribute psoriasis development
CONCLUSION: TNF-α initiates psoriatic inflammation by increasing CXCL-1/8 in keratinocytes mediated by the axis of NF-κB-hsa-miR-27a-3p-galectin-3 pathway.PMID:37358143 | DOI:10.1080/08923973.2023.2229510
Source: Immunopharmacology and Immunotoxicology - June 26, 2023 Category: Allergy & Immunology Authors: Xiao-Nan Qiu Dan Hong Zhen-Rui Shi Si-Yao Lu Yu-Xian Lai Yan-Ling Ren Xiu-Ting Liu Chi-Peng Guo Guo-Zhen Tan Liang-Chun Wang Source Type: research
Activation of ryanodine-sensitive calcium store drives pseudo-allergic dermatitis via Mas-related G protein-coupled receptor X2 in mast cells
Mast cell (MC) activation is implicated in the pathogenesis of multiple immunodysregulatory skin disorders. Activation of an IgE-independent pseudo-allergic route has been recently found to be mainly mediated via Mas-Related G protein-coupled receptor X2 (MRGPRX2). Ryanodine receptor (RYR) regulates intracellular calcium liberation. Calcium mobilization is critical in the regulation of MC functional programs. However, the role of RYR in MRGPRX2-mediated pseudo-allergic skin reaction has not been fully addressed. To study the role of RYR in vivo, we established a murine skin pseudo-allergic reaction model. RYR inhibitor att...
Source: Frontiers in Immunology - June 19, 2023 Category: Allergy & Immunology Source Type: research
TMEM232 Promotes the Inflammatory Response in Atopic Dermatitis via NF- κB and STAT3 Signaling Pathways
CONCLUSION: The study first outlines the function of TMEM232. It is involved in regulating inflammation in AD and may be a potential target for AD treatment.PMID:36928730 | DOI:10.1093/bjd/ljad078
Source: The British Journal of Dermatology - March 17, 2023 Category: Dermatology Authors: Jie Han Xinying Cai Shichun Qin Zengyunou Zhang Yuanyuan Wu Yuanzhe Shi Tingyue Deng Benjin Chen Li Liu Haisheng Qian Wenliang Fang Fengli Xiao Source Type: research
Osthole relieves skin damage and inhibits chronic itch through modulation of Akt/ZO-3 pathway in atopic dermatitis
Eur J Pharmacol. 2023 Mar 13:175649. doi: 10.1016/j.ejphar.2023.175649. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is the most prevalent chronic inflammatory skin condition and significantly reduces quality of life. Tight junction (TJ), which is located directly beneath the stratum corneum, maintains skin barrier function and aids in the identification of the cell's "territory". We evaluated seventeen TJ related genes to explore AD related alterations of TJ. Remarkably, we found that the expression of ZO-3, a gene that had not been linked to the development of TJ in AD, was significantly down-regulated in the ski...
Source: European Journal of Pharmacology - March 15, 2023 Category: Drugs & Pharmacology Authors: Xueqin Hu Yuan Zhou Jianxin Shi Mingxin Qi Xue Li Yan Yang Chan Zhu Changming Wang Zongxiang Tang Yuxiang Ma Guang Yu Source Type: research
Inhibition of serum and glucocorticoid-regulated protein kinase-1 aggravates imiquimod-induced psoriatic dermatitis and enhances proinflammatory cytokine expression via the NF-kappaB pathway
In this study, we found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, a specific pharmacological SGK1 inhibitor, EMD638683, significantly enhanced imiquimod (IMQ)-mediated TLR7/8 activity and proinflammatory cytokine production in RAW264.7 cells, and this result was confirmed by SGK1 siRNA.
Source: Journal of Investigative Dermatology - January 5, 2023 Category: Dermatology Authors: Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng Tags: Original Article Source Type: research
The Role of Collagen VI α6 Chain Gene in Atopic Dermatitis
CONCLUSION: The reduction of epidermal COL6A6 due to the genetic mutation can cause skin barrier damage and it can contributes to the early onset of AD. COL6A6 is induced by IL-4 and IL-13, and it may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD.PMID:35221595 | PMC:PMC8831303 | DOI:10.5021/ad.2022.34.1.46
Source: Annals of Dermatology - February 28, 2022 Category: Dermatology Authors: Hye Jung Jung Won Il Heo Kui Young Park Mi-Kyung Lee Ji Young Ahn Mi Youn Park Seong Jun Seo Source Type: research
