The Role of Collagen VI α6 Chain Gene in Atopic Dermatitis

CONCLUSION: The reduction of epidermal COL6A6 due to the genetic mutation can cause skin barrier damage and it can contributes to the early onset of AD. COL6A6 is induced by IL-4 and IL-13, and it may play a role in fibrotic remodeling and inflammatory processes, which are major features of AD.PMID:35221595 | PMC:PMC8831303 | DOI:10.5021/ad.2022.34.1.46

Source: Annals of Dermatology - February 28, 2022 Category: Dermatology Authors: Hye Jung Jung Won Il Heo Kui Young Park Mi-Kyung Lee Ji Young Ahn Mi Youn Park Seong Jun Seo Source Type: research