Inhibition of serum and glucocorticoid-regulated protein kinase-1 aggravates imiquimod-induced psoriatic dermatitis and enhances proinflammatory cytokine expression via the NF-kappaB pathway

In this study, we found that SGK1 expression was decreased in macrophages from psoriasis patients. Moreover, a specific pharmacological SGK1 inhibitor, EMD638683, significantly enhanced imiquimod (IMQ)-mediated TLR7/8 activity and proinflammatory cytokine production in RAW264.7 cells, and this result was confirmed by SGK1 siRNA.

https://www.jidonline.org/article/S0022-202X(23)00007-6/fulltext?rss=yes

Source: Journal of Investigative Dermatology - January 5, 2023 Category: Dermatology Authors: Qinqin Meng, Mei Bai, Meiliang Guo, Zhengxiao Li, Wanwen Liu, Xiaojing Fan, Rui Sun, Xinrong Yang, Dingfen Yuan, Yuling Shi, Hui Deng Tags: Original Article Source Type: research