894 Poly(I:C) and GAG inhibit exogenous HSV1 infection in the barrier dysfunctional 3D epidermal model

Skin barrier dysfunction often induces severe herpes simplex virus (HSV) infection that is known as Kaposi's varicelliform eruption (KVE). KVE often occurs on patients with atopic dermatitis or genetic skin disease such as Dariers disease (DD). The mechanism of KVE has not been clearly proved, and the preventive methods have not been found. We previously established a skin barrier dysfunctional 3D model using siRNA of ATP2A2 of which gene mutation is confirmed in DD. This 3D model has dyskeratosis and TEM observation clearly revealed epidermal cleft that is caused by the absence of desmosome at intercellular space in ATP2A2 silenced-3D (DD-like) epidermis.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Innate Immunity, Microbiology, Inflammation Source Type: research